January 2026 in “Biomacromolecules” This study presents a novel method for treating androgenetic alopecia (AGA) using a controlled rigidity nanolipogel (NLG) for the topical delivery of fucosterol. The NLG, with its lipid bilayer and alginate core, has its rigidity controlled by sodium alginate cross-linking. Among the tested formulations, the moderately rigid NLG-2.5 demonstrated superior transdermal permeability and hair follicle-targeting properties. It effectively inhibited inflammation and androgen pathways while promoting angiogenesis, leading to restored hair growth in AGA model mice. This approach offers promising insights for AGA treatment.
2 citations
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February 2024 in “Nature cell biology” Mechanical forces are crucial for shaping cells and forming tissues during development.
April 2025 in “Journal of Investigative Dermatology” Fibronectin is essential for hair follicle regeneration by supporting stem cells.
74 citations
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July 1991 in “The Journal of Urology” Minoxidil works better than nitroglycerin for treating impotence with fewer side effects.
58 citations
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September 1991 in “British Journal of Dermatology” Women with AGA often face anxiety, depression, and low self-esteem; psychological support is important.