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In this study, researchers observed that quiescent mouse embryonic fibroblasts showed reduced glycolysis but increased TCA cycle flux and mitochondrial respiration, with these changes linked to metabolic reprogramming involving yes-associated protein inhibition and malate cycle modulation, which supports extracellular matrix protein synthesis.

In this study, researchers found that epithelial cells exhibit density-dependent metabolic heterogeneity, particularly in the pre-epithelial transition stage, where metabolic patterns correlate with cell proliferation and are influenced by actomyosin contractility.

This study found that epithelial cell metabolism exhibits distinct heterogeneity based on cell density, particularly during the pre-epithelial transition stage where clusters of high and low mitochondrial potential cells emerge.

This case series described five patients with chronic alopecia areata who successfully maintained long-term disease control using a combination of topical immunotherapy and other treatments over 9–15 years, highlighting the approach's continued value alongside novel therapies.

This study suggests that PDCD4 regulates keratinocyte proliferation and contact inhibition, playing a role in epidermal homeostasis and wound healing.