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research The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor

178 citations , October 2001 in “Genes & Development”

This study found that the mammalian hairless gene encodes a corepressor protein that interacts with thyroid hormone receptors, providing insights into hair loss syndromes in humans and mice.

research Congenital hair loss disorders: Rare, but not too rare

41 citations , November 2011 in “The Journal of Dermatology”

This review identifies genetic mutations associated with congenital hair loss disorders in Japanese populations, particularly highlighting common LIPH gene mutations linked to woolly hair/hypotrichosis, and reports no new clinical results.

research Kyoto Rhino Rats Derived by ENU Mutagenesis Undergo Congenital Hair Loss and Exhibit Focal Glomerulosclerosis

9 citations , January 2011 in “EXPERIMENTAL ANIMALS”

This study describes a novel hairless mutant rat strain, F344-Hr(krh), developed via ENU mutagenesis, which provides a model for skin disease and potentially focal glomerulosclerosis due to specific genetic mutations.

research Differential diagnosis of hair loss in children. Differentialdiagnose des Haarausfalls bei Kindern

30 citations , May 2004 in “Journal der Deutschen Dermatologischen Gesellschaft”

This review proposes a classification system for childhood hair loss based on clinical appearance, age of onset, and associated symptoms, but reports no new clinical results.

research An Approach to Hair Loss in Pediatric Primary Care

8 citations , July 2021 in “Journal of Pediatric Health Care”

In this paper, the authors provide recommendations for primary care practitioners on evaluating and treating pediatric hair loss, emphasizing the importance of early diagnosis to prevent permanent scarring alopecia by classifying causes into acquired or congenital origins.

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Community Join

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community Hair loss research is a money grab

227 upvotes 10 months ago

Hair loss is linked to DHT, with treatments like finasteride and minoxidil being common but not definitive. Economic interests influence research, and there is potential for new treatments like PP405 and RU58841.

community I will never more buy any hairloss traitements in public pharmacy

in Minoxidil 420 upvotes 1 year ago

A user was embarrassed by a pharmacist's loud mention of "minoxidil" for hair loss, sparking a discussion on the stigma and unprofessionalism. Users suggested online purchases or different pharmacies for privacy and reassured that most people don't notice others' purchases.

community if Post Finasteride Syndrome is real. Why is it only the negative effects and not positive have log term effect?

in Finasteride/Dutasteride 63 upvotes 4 months ago

Finasteride is used for hair loss, with mixed reports of no side effects and claims of long-term negative effects known as Post Finasteride Syndrome (PFS). The conversation debates the existence and causes of PFS, with differing opinions on whether it is psychological or real.

community How a follicle next to it is so genetically different that it never miniaturized??

in Chat 219 upvotes 11 months ago

Genetic differences in hair follicles affect hair loss patterns. Treatments discussed include finasteride, dutasteride, minoxidil, and RU58841.

community Another transplant or SMP? (Not balding)

in Transplants 23 upvotes 8 months ago

The user is considering another hair transplant or scalp micropigmentation (SMP) for a congenital bald spot, but previous transplants were less effective due to scar tissue. Suggestions include using hair fibers, changing hairstyles, or doing nothing, as the spot is not very noticeable.

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Clinics

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Learn

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learn Alopecia Areata

autoimmune disorder causing patchy hair loss

learn Hair Transplant

Hair transplantation moves DHT-resistant follicles from a donor area (back and sides of the scalp) into thinning or bald areas. The transplanted hair is generally permanent, though surrounding native hair can keep thinning.

What is male pattern baldness? Male pattern baldness is a genetic condition causing hair loss in men, starting with a receding hairline.

learn TDM-105795

What types of alopecia or hair loss conditions might TDM-105795 be designed to target based on current research? TDM-105795 may target non-scarring alopecia, particularly androgenetic alopecia.

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