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      community Theoretically won't this be better than finasteride? Azelaic acid + zinc

       9 upvotes 3 years ago
      The conversation discusses using zinc sulphate and azelaic acid to inhibit 5 alpha-reductase activity, which could potentially treat androgen-related skin conditions like hair loss. Combining these with vitamin B6 could enhance the effect, potentially offering an alternative to finasteride.

      community Anyone here that's been using RU for 5+ years? [Serious]

       43 upvotes 3 years ago
      The conversation is about the long-term use of RU58841 for hair loss, with users sharing their experiences and seeking information on its effectiveness and whether it needs to be used continuously like minoxidil or finasteride.

      community The truth about Dutasteride (w/ sources)

      in Finasteride/Dutasteride  52 upvotes 3 years ago
      The effectiveness of Dutasteride compared to Finasteride in treating hair loss, with evidence given such as studies and experiences, as well as discussion around whether one should switch from Finasteride to Dutasteride. There is also a discussion on post-Dutasteride syndrome.

      community Why does this industry still revolve around 5-AR inhibitors?

       40 upvotes 5 years ago
      Hair loss treatments still rely heavily on minoxidil, finasteride, and RU58841, with little innovation. Future treatments like stem cell therapy and RNA technology show promise but are not yet available.

      community Stumbled on some research

       8 upvotes 5 years ago
      Elevated PGD2 levels in bald scalp tissue may contribute to hair loss, and treatments like castor oil, finasteride, and minoxidil are discussed as potential solutions. Some users explore alternatives like oral castor oil and cetirizine for those who cannot use finasteride.

      community What if DHT is not the vilan.

       13 upvotes 5 years ago
      Hair loss may be influenced more by inflammation, microbiome imbalances, and gut health than DHT. Treatments discussed include minoxidil, finasteride, RU58841, fecal microbiota transplants, and JAK inhibitors.

      community Riken develops new method for culturing hair follicles

       41 upvotes 8 years ago
      A new stem cell method for culturing hair follicles is being developed as an alternative to Minoxidil, finasteride, and RU58841. There are concerns about its cost and accessibility despite plans for commercialization.

      community GT20029 Will Replace Finasteride For Hair Loss

       58 upvotes 3 months ago
      GT20029 shows promise as a topical treatment for hair loss, potentially replacing finasteride for some due to its low systemic exposure and ability to degrade androgen receptors. However, skepticism remains about its long-term efficacy and availability, with some users expressing doubt about new treatments consistently failing to reach the market.

      community We already know how to permanently fix hair loss. The science is done. The only thing missing is the funding to run one experiment.

      in Technology  613 upvotes 4 months ago
      A permanent hair loss solution could involve reprogramming hair follicles to resist DHT using mRNA and siRNA. However, high costs, safety concerns, and the pharmaceutical industry's preference for ongoing treatments over one-time cures are major obstacles, with finasteride and minoxidil remaining standard treatments.

      community BREAKTHROUGH: I’m a radiochemist and discovered a radioactive isotope scalp serum that OUTPERFORMS Minoxidil and 5-AR inhibitors! (Lab Data Inside)

      in Satire 1 year ago
      A satirical post where someone claims to have developed a radioactive isotope scalp serum using Polonium-210 that outperforms Minoxidil and finasteride for hair regrowth. The serum reportedly stimulates DNA repair in hair follicles, leading to significant hair density increase, but the post is met with skepticism and concerns about safety.

      community Some of y’all need to hear this

      in Chat  351 upvotes 3 years ago
      Understanding that the importance of hair loss should not be overstated and encouraging self-love and confidence regardless of physical appearance. People discussed how they were feeling about their own hair loss and shared tips on treatments like Minoxidil, Finasteride and RU58841.

      community Finasteride - 5 years and my expierience

       128 upvotes 1 week ago
      A 26-year-old shared their 5-year experience using finasteride and minoxidil for hair loss, noting initial improvements but later experiencing reduced libido and erection quality, leading them to switch from oral to topical finasteride. They advise starting with a low-dose topical solution and emphasize making informed decisions, acknowledging that while finasteride is effective, it can have side effects.

      community Latest study on RU58841 done 19. August 2026.

       25 upvotes 3 weeks ago
      RU58841 can be absorbed systemically after topical application, but the study did not find immediate hormonal disruption. The study highlights the need for more research on long-term safety and effects of RU58841, as well as the importance of quality control in products from the grey market.

      community The number of hairs lost when i washed my hair during first minoxidil shed (and the ratio of mature vs miniaturized hair)

      in Minoxidil  89 upvotes 3 months ago
      The user is experiencing a minoxidil shed after six months of use, noting a significant number of miniaturized hairs compared to mature ones, and has been on finasteride 0.5mg daily for two years with positive results. The user meticulously counts and categorizes shed hairs, sparking reactions ranging from amusement to concern over the level of obsession.

      community Modifiability of the aging process

       17 upvotes 3 months ago
      Hair loss is largely influenced by genetics, with treatments like finasteride, minoxidil, and RU58841 being used to manage it. Despite healthy lifestyles, hair loss can still occur, highlighting the complex relationship between genetics, health, and aging.

      community Oral fin -> topical, shedding like hell

      in Finasteride/Dutasteride  19 upvotes 4 months ago
      The user experienced severe side effects from oral finasteride, including sexual dysfunction and mental health issues, and switched to topical finasteride, which led to significant hair shedding. They are considering other treatments like RU58841 or topical dutasteride and are advised to check testosterone levels and address potential underlying health issues.

      community VDPHL01 phase-2/3 results comparison

      in Research/Science  128 upvotes 4 months ago
      The conversation discusses hair loss treatments, focusing on a new slow-release oral minoxidil compared to topical minoxidil and finasteride. The results show that twice-daily dosing of the new treatment is slightly more effective than once-daily, but concerns about cost, side effects, and the accuracy of reported results remain.

      community DHT is NOT very important for adults, is it?

       124 upvotes 4 months ago
      A user experienced negative side effects, including low libido and lack of motivation, after using finasteride for hair loss and felt better after stopping it. Others shared similar experiences with finasteride and dutasteride, while some reported no side effects, showing varied individual responses.

      community My 2 Years Progress (Hair Recovery)

       1465 upvotes 4 months ago
      A person shared their hair regrowth journey using HIMS topical treatments with finasteride, minoxidil, hormone replacement therapy (HRT), and microneedling. They also discussed their transition as a transgender woman and the positive impact of HRT on hair recovery.

      community Sooo whats the consensus about pp405 now?

      in Chat  75 upvotes 5 months ago
      PP405 may help with hair regrowth, especially when combined with minoxidil and finasteride, but its long-term effectiveness is unclear. Phase 3 trials are expected to begin soon, with results in a few years.

      community Reducing Fibrosis in Hair Loss: Topical Pirfenidone

       59 upvotes 5 months ago
      Topical pirfenidone is highlighted as an effective anti-inflammatory and anti-fibrotic treatment for hair loss, particularly in addressing perifollicular fibrosis, which may enhance the effectiveness of standard treatments like finasteride and minoxidil. The user also uses calcipotriol, MCT oil, ciclopirox shampoo, and benzoyl peroxide shampoo as part of their regimen.