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      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 4 months ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community Trestolone (MENT) as a nuclear treatment

      in Treatment  99 upvotes 2 years ago
      Experimenting with trestolone as a treatment for hair loss in an attempt to avoid DHT-related treatments such as finasteride and dutasteride, and discussing the potential effects of its receptor selectivity on the androgen receptors in the scalp.

      community CRISPR treatment for AGA on the horizon after approval for blood disorders

      in Treatment  10 upvotes 10 months ago
      CRISPR treatments for blood disorders have been approved, leading to discussions about its potential for treating hair loss (AGA). A study showed that editing a gene related to DHT sensitivity could lead to hair regrowth, suggesting CRISPR may eventually be used for AGA, but it's expected to be expensive and not soon available.

      community Genetic testing to determine individualized hairloss treatment?

      in Research/Science  10 upvotes 1 year ago
      A user discusses a company, Roots by Genetic Arts, that offers a genetic test for hair loss to create personalized treatments, and is curious about its legitimacy and the science behind it. The company tests 16 genes related to hair loss and compounds a topical treatment based on the results.

      community Is itching related to hair loss?

      in Treatment  54 upvotes 2 years ago
      Hair loss, which is sometimes accompanied by itching. Treatments discussed include Minoxidil, finasteride, RU58841 and ketocazole shampoo.

      community First time at the barber since 9 months.

      in Chat  65 upvotes 8 months ago
      A person shared their experience of going to the barber for the first time in 9 months after starting treatment with finasteride and minoxidil for hair loss. Another person related to this experience and mentioned they also started these treatments and previously used topical minoxidil with little effect.

      community Keratin microspheres - breakthrough

      in Research/Science  13 upvotes 9 months ago
      A gel of keratin microspheres promotes hair follicle growth, showing similar effectiveness to minoxidil in mice. The treatment activates hair growth pathways and reduces inflammation, with potential applications in drug delivery for hair-related disorders.

      community Question to people who shed on RU58841

      in Research/Science  7 upvotes 1 year ago
      The user experienced significant hair loss after using RU58841, a hair loss treatment, and had to undergo a hair transplant to rectify the damage. They're asking others who've used RU58841 about their experiences, particularly if they also experienced shedding, if their hair grew back, when they started using RU, and other related questions.

      community More pre fin to today hair photos

      in Progress Pictures  16 upvotes 8 months ago
      The user shared progress pictures showing hair loss improvement after using finasteride for about a year and plans to get a hair transplant in May, while also considering adding minoxidil to their treatment. They also mentioned using Nizoral and Neutrogena for dandruff, which may be related to the hair loss treatment.

      community I solved my scalp inflammation

      in Treatment  30 upvotes 9 months ago
      A user solved their 15-year scalp inflammation and related hair loss using Selenium Sulfide shampoo (Selsun Blue), noticing improvement after the first use and resolution after three uses. Others found relief with Ketoconazole shampoo, which also helps with hair loss.

      community Antihistamines stop my hair loss

      in Treatment  23 upvotes 2 years ago
      A user found that antihistamines stop their hair loss and related symptoms, but they experience side effects like sedation and chest pain. They are seeking alternative solutions or topical antihistamines to avoid systemic side effects.

      community Oral min vs topical comparison

      in Treatment  10 upvotes 2 months ago
      Oral minoxidil is claimed to be more effective and easier to use than topical minoxidil, with a 100% response rate, but it may cause unwanted body hair growth and has potential heart-related side effects. Topical minoxidil is less effective for many due to enzyme limitations, can cause scalp issues, and is more challenging to apply, but it avoids systemic side effects.

      community Best Treatment In The Pipeline?

      in Chat  15 upvotes 5 months ago
      New treatments for AGA are emerging, including pyrilutumide, gt0029, scube3, kx-826, and pp405. Verteporfin is mentioned as a promising option.

      community Platelet rich plasma treatment

      in Treatment  4 upvotes 8 months ago
      A 27-year-old male experienced rapid hair loss after dengue fever, which activated a balding gene. The doctor suggested platelet-rich plasma treatment for hair regrowth.

      community The treatment paradox: Start your treatment and get the fuck off of this subreddit

      in Chat  120 upvotes 4 years ago
      The conversation emphasizes the importance of starting hair loss treatment early, using options like minoxidil, finasteride, RU58841, essential oils, and dermarolling, and encourages leaving the hair loss subreddit once treatment begins to avoid stress and obsession. Users shared personal success with finasteride and the motivation to start treatment to prevent future regret.

      community What would hair loss treatment be like in the 2030s?

      in Treatment  5 upvotes 5 months ago
      The conversation discusses future hair loss treatments, with mentions of dutasteride potentially gaining FDA approval and increased popularity. Skepticism remains about significant advancements due to limited funding and reliance on cosmetic companies.

      community Upcoming treatment ideas in the future

      in Research/Science  10 upvotes 1 month ago
      Exploring future hair loss treatments, including immunosuppressants for hair transplants and hair cloning, with a focus on leveraging research from other medical fields. Current treatments like finasteride and minoxidil are effective for most, but there's a call for more funding and innovation in the hair loss industry.

      community Hair loss treatment tier list by Dr Oscar Muñoz

      in Treatment  920 upvotes 4 months ago
      Dr. Oscar Muñoz's hair loss treatment tier list suggests oral minoxidil and finasteride are highly effective, while topical treatments like RU58841 and microneedling are less effective. Users discuss the effectiveness of various treatments, with some favoring oral options for their practicality and higher response rates.

      community Atherosclerosis as cause of balding and treatment

      in Treatment  61 upvotes 1 year ago
      Hair loss may be caused by calcification of capillaries in the scalp, restricting blood flow to hair follicles. A daily treatment regimen including high doses of Vitamins D and K, Magnesium, and Nattokinase could potentially decalcify these capillaries, improving blood flow and hair growth. However, some users warn against excessive Vitamin D intake and emphasize the need for medical consultation.

      community Treatment does not seem to be working

      in Finasteride/Dutasteride  11 upvotes 1 year ago
      A 22-year-old male has been treating hair loss for over three years with various methods including minoxidil, finasteride, dutasteride, and other treatments, but continues to experience hair thinning. Despite trying multiple treatments and consulting with dermatologists and hair surgeons, the individual is frustrated with the ongoing hair loss and lack of progress.