TWIST-1 gene's role in hair loss and potential as a treatment target. Inhibiting TWIST-1 may prolong hair growth and reduce hair follicle sensitivity to DHT.
A user named "bmbshell" who was dealing with hair loss and initially tried to fix it with a hair system before deciding to try finasteride, dutasteride, minoxidil, microneedling, and biotin supplements. They documented their progress over the past 1 year and 3 months, showing how effective these treatments were in regrowing their hair.
Female using Rogaine foam for hair loss had scalp punch biopsy, diagnosed with Androgenetic Alopecia (AGA). Doctor recommended starting Spironolactone 50mg.
A user shared progress pictures showing hair improvement after using oral finasteride and topical minoxidil for two and a half months. They are considering a hair transplant but are advised to wait for full results from the treatments.
The conversation discusses whether dutasteride might cause less depression than finasteride for hair loss treatment, with some users suggesting it could due to different mechanisms of action or molecular size, while others express skepticism or share personal experiences with these medications.
The user has been using a strong combination of hair loss treatments for 16 months, including Finasteride, Minoxidil, Dutasteride, and RU-58841, but their hair loss has worsened. They're questioning whether their high testosterone levels or residual scalp DHT are causing further hair loss, with a reply suggesting that even small amounts of DHT can cause hair loss if one is sensitive to it.
PP405 is not a cure for hair loss but may reactivate dormant hair follicles, similar to minoxidil. It is unlikely to help with miniaturized or vellus hairs and is still in trial phases, with availability expected around 2030.
ET-02, a new hair loss treatment, shows promising results with a 6-fold increase in hair count, potentially outperforming minoxidil by activating stem cells in hair follicles. Further trials are ongoing to confirm its efficacy and safety, with potential market release in the future.
Phase II for TDM-105795 for Androgenic Alopecia is set to begin in April 2023. The study aims to evaluate the efficacy and safety of TDM-105795 in male subjects.
The conversation discusses the slow transition from baby hair to normal hair while using finasteride and transitioning to dutasteride, with progress except for the crown area. It's mentioned that hair thickening can take years, with each growth cycle potentially making the hair thicker, and this process can span over 6 months or more.
Users discussed the convenience and effectiveness of Hims Fin+Min chewable tablets for hair loss. Some believe it's overpriced compared to traditional oral finasteride and minoxidil, while others find it more convenient and potentially more effective.
A user reported that Minoxidil, a hair growth treatment, stopped working for them despite initial success. Other users suggested not taking breaks from the treatment, checking for fake products, trying microneedling, using oral Minoxidil, combining Minoxidil with tretinoin, and using finasteride.
The potential of using a specific antibody, HMI-115, as a treatment for hair loss alongside traditional treatments such as minoxidil and finasteride. The user suggests trying either a 240 mg or 30 mg dose to see if it works.
He Shou Wu (Fo Ti) extract was found to prolong the hair growth phase, inhibit 5-alpha-reductase (like finasteride), reduce androgen receptors, and increase growth factors, potentially outperforming minoxidil in recovering hair follicle size after DHT exposure. Two compounds, emodin and TSG, are identified as responsible for these effects and warrant further investigation.
Naepo's 5-month progress report detailing their journey of treating male pattern baldness with dutasteride and oral minoxidil, which has already resulted in an encouraging improvement in hair density. Others have responded with appreciation for the thorough report and asked further questions about Naepo's educational background.
Switching from finasteride to dutasteride for hair loss can cause increased shedding, which may indicate the treatment is working by replacing old hairs with new ones. The original poster is experiencing aggressive hair thinning despite long-term treatment.
The user is experiencing hair loss and is considering using finasteride again, along with ketoconazole shampoo and curl cream, to manage their long hair. They are concerned about the appearance of new hair growth and the potential shedding phase from minoxidil.
The user experienced increased hair thinning after switching from finasteride and minoxidil to dutasteride, despite some users suggesting it might be a temporary shedding phase. The user is considering using RU58841 but is unsure about its safety.
A user is experiencing significant hair shedding after starting a treatment regimen of 1mg oral finasteride, 3mg oral minoxidil, 2.5mg biotin, and vitamins. Despite the shedding, they remain optimistic and plan to continue the treatment for a year before making any conclusions.
A user who experienced hair loss after switching from finasteride to dutasteride and is seeking advice whether it is an indication the treatment isn't working. Replies suggest that shedding is common at first due to dutasteride's longer half-life, but patience may be necessary before results are seen.
People discussing their experiences with hair loss treatments found that switching from finasteride (Fin) to dutasteride (Dut) often resulted in improved hair thickness and health, despite some experiencing side effects or shedding phases. Some users switched due to diminishing results with Fin, while others were curious about the potential for better outcomes with Dut.
Finasteride isn't working after 8 months, and stopping minoxidil led to no regrowth. Advice includes resuming minoxidil, correcting iron deficiency, and continuing finasteride.
Switching from finasteride to dutasteride as a treatment for hair loss, with advice given that titrating up to daily use is optimal and results may be seen after one year. Additionally, the user mentioned adding topical minoxidil 5% which has produced good results.
Hair loss treatments, including the use of Minoxidil and Finasteride, with a user sharing their 8-month update on progress made. Others have chimed in to provide encouragement and advice for continued treatment.
The user, Virtual_Force3845, shared their progress pictures after using Hims Fin/Min Spray consistently for 3-4 months. They are excited about the progress and have not experienced any side effects. Other users in the conversation shared their own experiences and asked questions about the treatment.
Finasteride is increasingly prescribed to young men to prevent hair loss, with many users expressing regret for not starting sooner. The conversation highlights the preference for Finasteride, Dutasteride, and Minoxidil over other treatments.
Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.
Dutasteride is reported by some users to worsen hair loss, while others believe it causes shedding before improvement. Finasteride and Minoxidil are also mentioned as treatments, with mixed results.
Dr. Tsuji and Riken announced a hair cloning cure with a 98.9% success rate, expected to be released in 10 years. Users expressed hope and skepticism about the affordability and timeline of the treatment.