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      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 3 months ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community 3 months of Topical Fin/Min update

      in Progress Pictures  330 upvotes 1 year ago
      The user "RenegadeMountie" shared their progress with topical finasteride and minoxidil for hair loss. They reported consistent use for 3 months, with noticeable improvement in hair thickness and new growth. Other users recommended using hair loss concealers and expressed confidence in seeing more progress in the future.

      community M22 1 year 4 months topical min + oral fin

      in Finasteride/Dutasteride  216 upvotes 1 year ago
      A user's experience with hair loss treatments, specifically Minoxidil (topical) and Finasteride (oral), over a period of 1 year and 4 months. The user reported best results after 6 months, a significant hair shed 4 months ago, and current regrowth, while also using a 1.25mm dermastamp. The user adjusted Finasteride dosage over time and experienced high testosterone and nipple sensitivity.

      community 1 Year Progress (11.5 months topical min 2x daily, 1mg fin daily, 9 months 1.5mm microneedling 2x weekly (-> 1x/weekly 3 months ago), 11 days 1.25mg oral min, nizoral every 3 days)

      in Progress Pictures  390 upvotes 8 months ago
      The user shared a 1-year progress on hair loss treatment using topical minoxidil twice daily, finasteride daily, microneedling, oral minoxidil, and Nizoral every three days, showing significant improvement. Commenters expressed admiration for the results and hope for their own hair recovery.

      community Boys I am just a gonner. What on earth is my scalp even going through. Looks like world war 3. Pyril 3 months. Topical melitonin/progesterone/fin, dut, fin, oral min, laser trash, anus stimulation. Nothing. Donor area is decimated 😂.

      in Progress Pictures  83 upvotes 2 years ago
      Treating Seborrheic Dermatitis, a fungal scalp condition which can cause hair loss. Treatments discussed include antifungal shampoos, cold showers, exfoliating the scalp, taking Vitamin D, and stimulating the prostate through the anus.

      community Minoxidil Finasteride heart problems

      in Update  97 upvotes 7 months ago
      A user experienced heart problems after taking 1mg finasteride and 2.5mg oral minoxidil and is considering quitting minoxidil. Others discussed their experiences with heart issues and minoxidil, with some suggesting topical minoxidil as a safer alternative.

      community Exploring Bryan Johnson's Hair Routine In Detail

      in Research/Science  64 upvotes 11 months ago
      Bryan Johnson uses a custom hair loss treatment that includes topical finasteride, minoxidil, azelaic acid, diclofenac, tea tree oil, rosemary oil, ginkgo biloba, biotin, and melatonin, which have shown varying degrees of effectiveness with minimal side effects. He also undergoes PRP and laser therapy, and has tried dutasteride mesotherapy.

      community Is the Ru58841 hype justified?

      in Treatment  17 upvotes 2 months ago
      RU58841 is debated for hair regrowth, with some users reporting no benefits and potential side effects, while others claim success when combined with dutasteride. Many suggest safer, well-researched treatments like finasteride and minoxidil for hair loss management.

      community hair loss treatment myths that perplex me

      in Treatment  8 upvotes 2 months ago
      Grapefruit juice doesn't significantly affect finasteride or dutasteride. Drinking topical minoxidil is risky; saw palmetto is less effective than finasteride or dutasteride for hair loss.

      community Clascoterone study going on right now

      in Research/Science  355 upvotes 7 months ago
      A user is participating in a phase 3 trial for Clascoterone, a topical acne medication that may stimulate hair growth, and will share results after 6 months. They will have a section of their hair shaved and marked with a tattoo for the study.

      community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

      in Research/Science  65 upvotes 1 year ago
      Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

      community Low-Dose Oral Minoxidil Does Not Significantly Affect BP

      in Minoxidil  178 upvotes 1 month ago
      Low-dose oral minoxidil is used for hair loss and does not significantly affect blood pressure but may increase heart rate and cause hypotensive symptoms. Some users experience side effects like palpitations and shortness of breath, while others find it effective; topical minoxidil with tretinoin is also considered.

      community 27/M closing in on a year of fin and min, feel like it’s only gotten worse.

      in Chat  62 upvotes 4 months ago
      A user reported no improvement in hair loss after nearly a year of using 1mg oral finasteride, topical minoxidil twice daily, and weekly microneedling. Other users suggested the possibility of DUPA or retrograde alopecia and mentioned that treatments might only slow down hair loss rather than regrow hair.

      community Why is it "not right" to start off with Dutasteride?

      in Finasteride/Dutasteride  60 upvotes 5 months ago
      The conversation discusses whether it's better to start hair loss treatment with finasteride or dutasteride. Opinions vary, but many suggest starting with finasteride due to its shorter half-life and easier management of side effects, while others argue dutasteride is more effective and has fewer side effects.

      community An updated, simple guide to the most effective hair loss treatments

       193 upvotes 5 years ago
      Effective treatments for hair loss, including Dutasteride, Finasteride, Minoxidil, Dermarolling, LLLT, PRP, Ketoconazole, and Scalp Massage. In addition, anti-inflammatory diets and stress management are recommended to maintain or regrow hair.

      community I am a dermatologist with a clinical interest in alopecia. AMA

      in Will treatment work for me? 2 years ago
      In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

      community [21M] 3,5 Year Finasteride&Minoxidil Progress (Detailed & Pics)

      in Progress Pictures  67 upvotes 9 months ago
      A 21-year-old male shared his nearly 4-year experience with hair loss treatments, including finasteride, minoxidil, and other products, with initial success followed by shedding. He now continues with finasteride and oral minoxidil, noting changes in hair texture and slight hairline recession.

      community Oral Minoxidil Users In A Nutshell

      in Satire  1212 upvotes 2 years ago
      This conversation is about hair loss treatments, specifically oral minoxidil and finasteride. Users discussed the potential side effects of using these drugs, as well as their experiences with them.

      community got my life back (4 months min/dut)

      in Progress Pictures  276 upvotes 8 months ago
      A user shared their successful hair regrowth experience after using minoxidil and dutasteride for four months, overcoming severe hair loss due to genetics. They also used vitamins, shampoo, a dermaroller, and a scalp massager, and saw significant improvement, gaining back their hair and confidence.

      community Update: 18 months - June ‘22-Jan ‘24

      in Progress Pictures  530 upvotes 10 months ago
      The conversation is about a user sharing an 18-month update on their hair loss treatment, which includes finasteride, minoxidil, and weekly microneedling. They noticed hair regrowth after 3 months and are using a combination spray of finasteride and minoxidil.

      community Why is no one pointing out dandruff as the number 1 evidence/symptom of MPB?

      in Chat  55 upvotes 1 year ago
      The post discusses the theory that persistent dandruff in areas prone to hair loss could be a sign of hair follicles dying due to DHT, indicating balding. The responses vary, with some users noting improvements in dandruff and hair loss with treatments like Dutasteride, while others experienced hair loss without dandruff.