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GlossaryTopical Treatments (topical drugs)

medications applied directly to the skin or scalp

Topical treatments, also known as topical agents or topical medications, are medications applied directly to a specific area of the skin or scalp to treat localized conditions. These treatments can include creams, gels, ointments, and lotions, and are commonly used for conditions like alopecia, psoriasis, and eczema, delivering active ingredients directly to the affected area to minimize systemic side effects.

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community Protac degradation of the androgen receptor in mice shows good efficacy and no systemic drug could be found

in Research/Science 47 upvotes 1 year ago

The efficacy of degrading the androgen receptor through dermal application in DP cells, a delivery system for topical drugs that involves dissolving microneedles, and rosemary oil as an alternative anti-androgen.

community Topical minoxidil 3 months results

in Progress Pictures 624 upvotes 2 years ago

This conversation is about a user named "mr_mime125" who experienced results from using topical finasteride (0.1%) and minoxidil (5%) solution 1.5 ml twice a day for the first two months followed by just minoxidil (5%) 1 ml once a day in the last month, resulting in a drastic improvement to their hairline. Other users discussed their progress while asking questions and offering encouragement.

community Complete Guide to Orally Taking Topical Minoxidil

in DANGEROUS / UNPROVEN 149 upvotes 2 years ago

Taking topical minoxidil orally for hair loss treatment, discussing safety, dosing, side effects, and FAQs. Users express concerns about safety and potential heart damage, while others share experiences and results.

community Is there a topical androgen receptor blocker so we don't have to fuck with the enzyme and destroy our allopregnanolone, but go and hit the end target straight?

in Treatment 46 upvotes 6 months ago

The conversation discusses topical androgen receptor blockers for hair loss, mentioning Clascoterone, Pyrilutamide, GT20029, and RU58841. Ketoconazole's effectiveness and application methods are also debated.

community drinking topical minoxidil – extreme hair growth everywhere

in Minoxidil 396 upvotes 2 years ago

At this point. In this conversation, users discussed the risks of drinking topical minoxidil and suggested alternative treatments such as obtaining a prescription for oral minoxidil or finasteride.

community Everyone seems to be looking for an antiandrogen as an add on. But what about Estradiol & its derivatives ( excluding the low concentraion alfatradiool ) being used. Anyone has an experience with this ? Anything that won't cause feminization in the process ?

in Chat 6 upvotes 2 months ago

The conversation discusses using estradiol and its derivatives for hair loss without causing feminization. Users mention alternatives like alfatradiol, topical 17b-Estradiol, and DIM (Diindolylmethane).

community Short Term Fin awaiting advances in medical technology.

in Finasteride/Dutasteride 36 upvotes 1 year ago

The user's consideration of taking finasteride as a short-term treatment, while awaiting advances in medical technology such as Pyrilutamide and GT20029; other users' experiences with Finasteride, including potential side effects.

community Bryan Johnson just dropped his anti hair loss formula

in Treatment 339 upvotes 9 months ago

Bryan Johnson shared his hair loss treatment, which mainly relies on minoxidil and finasteride. Some users are skeptical of his results, while others appreciate his efforts in anti-aging and hair loss research.

community Best Shampoos/Hair Styling Products for Thinning Hair (Male)

9 upvotes 8 years ago

A user is seeking advice on shampoos and hair styling products to slow down hair thinning and avoid harmful chemicals. They currently use a biotin and collagen shampoo and are considering alternatives like wax or oils instead of gel.

community I spoke to the Guy who did the Ru58841 (PSK-3841) research

in Research/Science 288 upvotes 3 years ago

The conversation discusses RU58841, a compound for hair loss treatment, which was found to be effective in a 6-month trial but was not pursued due to financial issues or marketability concerns, not safety. Some users are considering crowdfunding to release the research data, while others discuss personal experiences and safety concerns with RU58841.

community Minoxidil Alternative? | Bimatoprost & Latanoprost

in Minoxidil 13 upvotes 1 year ago

Exploring alternatives to Minoxidil for hair loss, such as Bimatoprost and Latanoprost, as well as potential treatments like Finasteride and RU58841.

community Oral min vs topical comparison

in Treatment 10 upvotes 1 month ago

Oral minoxidil is claimed to be more effective and easier to use than topical minoxidil, with a 100% response rate, but it may cause unwanted body hair growth and has potential heart-related side effects. Topical minoxidil is less effective for many due to enzyme limitations, can cause scalp issues, and is more challenging to apply, but it avoids systemic side effects.

community 6-months on Hims topical minoxidal and finasteride combination, and microneedling once every week or two. The before pic was taken with the front iphone camera so is lower resolution which makes a comparison hard, but perhaps seeing some minor gains in individual hairs thickening.

in Progress Pictures 2 years ago

Using a combination of topical minoxidil and finasteride, plus microneedling, to treat hair loss; the progress made by the original poster over 6 months; the potential for further results with longer use; and the possibility of seeking alternatives such as a hair transplant or system.

community to all people who cannot tolerate anti androgens (loe dose topical fin, pyrilutamide, CB) i am getting desperate, looking for a solution

in Research/Science 13 upvotes 1 year ago

The user tried Minoxidil without success, and Finasteride worked but caused sexual side effects even at a very low dose. They are seeking alternative treatments for hair loss as they cannot tolerate anti-androgens and are also in therapy for mental health.

community Why I decided to stop using minoxidil

in Minoxidil 59 upvotes 1 year ago

The user stopped using minoxidil due to inconvenience and negative effects on hair appearance, opting to continue with finasteride and dermarolling. Other users shared mixed experiences with different minoxidil brands and forms, including oral minoxidil.

community Homemade topical fin vs. pharmacy made topical fin

in Finasteride/Dutasteride 6 upvotes 2 years ago

A user is considering making their own topical finasteride from crushed Propecia tablets and asks if there would be any difference compared to pharmacy-made versions or products like Essegen-F. They note that making drugs at home is generally not recommended.

community New topical Dutasteride from Moogene will have 20 times better scalp absorption than oral Dutasteride. And much lower system absorption.

in Finasteride/Dutasteride 178 upvotes 2 years ago

A new topical Dutasteride with 20 times better scalp absorption being developed and tested for release in 2023; use of existing drugs, such as Minoxidil and finasteride; and mesotherapy as an alternative hair loss treatment.

community Cheap and Easy Hair Loss Treatment Drugs Megathread

in Product 13 upvotes 3 months ago

The conversation discusses affordable hair loss treatments, including oral dutasteride, oral and topical minoxidil, oral finasteride, 2% ketoconazole shampoo, and topical finasteride/minoxidil mixtures. Users share methods to obtain these drugs cheaply and legally.

community I don’t even care about my hair I just like taking drugs

in Satire 1 year ago

A user's experimentation with various hair loss treatments, including medications and topical applications; as well as their desire to experience unusual sensations through the use of drugs.

community Why Viagra promotes hair growth like oral minoxidil

in Minoxidil 84 upvotes 2 years ago

How oral minoxidil and topical sildenafil (similar to Viagra) are used for hair growth by increasing blood flow to the scalp, and potential side effects of combining these treatments with other drugs.

community Kintor develop GT20026 Anti-Androgen receptor drug with NO SIDES

in Treatment 16 upvotes 3 years ago

The conversation discusses GT20029, a new topical drug for hair loss and acne without notable side effects, which has been accepted for investigational use in China. Some users express skepticism about the legitimacy of the company and the potential for other drugs like RU58841 to be developed due to patent expiration and lack of profitability.

community 2020 Hair and Scalp Treatments: A Clinical Guide (in Depth 350 Page Guide)

in Treatment 62 upvotes 4 years ago

Treatments for hair loss, including topical immunotherapy, regenerative treatments, laser and light-based therapies, oral supplements, intralesional steroids, and new drugs like finasteride and minoxidil.

community Kintor Phase 2 Results released KX-826 (pyrilutamide)

in Research/Science 449 upvotes 2 years ago

Kintor Pharmaceutical's Phase 2 results with the drug Pyrilutamide, a potential alternative to 5-ARI drugs like Finasteride and Dutasteride but without the side effects. It could be used in combination with other topical treatments such as Minoxidil. The safety of the drug has been demonstrated in 6 months of use, however there are still questions about long term efficacy and systemic absorption.

community Anti-Androgens causing hairline to recede?

in Research/Science 5 upvotes 4 months ago

Anti-androgens like Finasteride, Dutasteride, Metformin, and Topical Spironolactone cause hairline recession and increased cholesterol levels. The hairline recovers after stopping the drugs.

community here is why isotretinoin might cause hair loss and maybe why dupa happens.

in Research/Science 7 upvotes 1 year ago

Isotretinoin may cause hair loss by increasing DHT through a precursor androgen, DHEAS. Treatments like topical antiandrogens (RU58841, pyrilutamide) and drugs increasing PPAR-y expression (pioglitazone) might prevent this hair loss.

community DUT Risk profile for having kids?

in Finasteride/Dutasteride 5 upvotes 1 year ago

The user has been using a hair loss treatment including oral Minoxidil, topical Minoxidil with Tretinoin and Finasteride, and is considering adding Dutasteride but is concerned about the potential side effects and risks regarding fertility. A reply suggests that having children while on these medications should be fine, advising to avoid letting the partner come into contact with the drugs.

community Hair progress over 7 years (Oral fin 1mg + oral min 2.5mg + topical min 5% + micro-needling)

in Progress Pictures 193 upvotes 7 months ago

The user shared a 7-year hair progress journey, starting with occasional minoxidil use and later including a finasteride prescription, online prescriptions, and microneedling. Significant hair growth was achieved, but side effects led to a reduction in medication dosage.

community Topical finasteride results .1%

in Progress Pictures 15 upvotes 11 months ago

The user has been using 0.1% topical finasteride and topical minoxidil for hair loss, and has now been prescribed Dutasteride. They also use a derma pen, ketoconazole shampoo, and a mix of oils for treatment.

community All Drugs in Clinical Trials in 2023

in Research/Science 70 upvotes 1 year ago

12 companies having drugs or therapies in clinical trials during 2023, with various molecules and phases of trial; the probability that some may fail; and progress being made in the field.

community Topical Dutasteride & Microneedling Works

in Finasteride/Dutasteride 5 upvotes 2 months ago

Topical dutasteride, especially at higher concentrations, can be effective for hair loss when combined with microneedling to enhance absorption. Users discuss the side effects of finasteride and dutasteride, with some preferring topical treatments to avoid systemic side effects.