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GlossaryTissue Remodeling (Tissue Reorganization)

process of altering tissue structure and function in response to stimuli

Tissue remodeling is the process by which the structure and function of tissues are altered in response to various stimuli, such as injury, disease, or normal growth. This involves the breakdown of old or damaged tissue and the formation of new tissue, often mediated by cells like fibroblasts and enzymes like matrix metalloproteinases. This process is crucial for wound healing, organ development, and maintaining tissue homeostasis.

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community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

in Research/Science 742 upvotes 2 years ago

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

community 15 months on the Big 3! My journey so far…

in Progress Pictures 162 upvotes 2 years ago

A user's progress after 15 months of using the "Big 3" treatments for hair loss (finasteride, minoxidil and micro needling) as well as Nizerol 2%. The post encourages others to seek out available information on hair loss treatment and reassures them that if it doesn't work, it is only hair.

community Why is nobody studying the difference between donor and balding hair?

in Chat 89 upvotes 6 months ago

The conversation discusses why the difference between donor and balding hair isn't studied more to find a cure for hair loss. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community Very reluctantly starting Finasteride.

in Finasteride/Dutasteride 84 upvotes 9 months ago

A 23-year-old started taking 0.25 mg of Finasteride daily for hair loss after trying Minoxidil and derma rolling without success. People shared varied experiences with Finasteride, discussing potential side effects, effectiveness, and personal decisions regarding hair loss treatment.

community Boys how is no one seeing positive results from pyrilutamide

in Chat 25 upvotes 1 year ago

Pyrilutimide, a treatment for hair loss; it's effectiveness compared to other treatments such as Finasteride and RU58841; and some users’ experiences with the treatment.

community Post Finasteride Syndrome, A dangerous lie.

in Chat 142 upvotes 10 months ago

A user initially had side effects from finasteride, attributed them to anxiety and the nocebo effect, and after resuming the drug, experienced positive effects and now warns against misinformation about Post Finasteride Syndrome.

community How is there still no consensus on Topical Dutasteride in 2024?

in Finasteride/Dutasteride 147 upvotes 7 months ago

The conversation expresses frustration over the lack of clear evidence regarding the effectiveness and systemic impact of topical Dutasteride for hair loss treatment, despite years of discussion. People are criticized for not conducting proper research and for providing contradictory anecdotal claims.

community This is the best time in human history to be fighting hair loss

in Treatment 193 upvotes 2 years ago

This conversation discusses the advancements in treatments for hair loss, including finasteride, dutasteride, minoxidil and new promising treatments such as pyrilutamide and verteporfin. Other treatments discussed were taking minoxidil orally, tretinoin to turn non-responders into responders and microneedling to further boost growth.

community I’m gutted and this is my last post on this thread

in Update 190 upvotes 2 years ago

User tried various hair loss treatments without success and plans to consult a dermatologist and possibly shave head for emotional well-being.

community Received a hair transplant today at 22 years old

in Transplants 108 upvotes 5 years ago

A 22-year-old's experience with receiving a hair transplant and the use of Minoxidil, finasteride, RU58841, Lidocaine shots, and platelet injections to treat hair loss.

community Take The Jump - Get The Hair Transplant

in Progress Pictures 338 upvotes 1 year ago

User got a hair transplant and it improved their life. Transplanted hair lasts, but medication like finasteride is needed to maintain non-transplanted hair.

community So we have 20k dollars human like machines available but no new effective treatment for hairloss since finasteride :)

in Chat 237 upvotes 2 months ago

There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.

community The theory that explains everything. Please help me make this big!

in Research/Science 2447 upvotes 3 years ago

The post and conversation are about the role of the enzyme 3alpha-hydroxysteroid reductase in hair loss and the potential of compounds like procyanidin B2 and sulforaphane to boost its activity for hair regrowth. Further research is needed to develop effective treatments based on this theory.

community Increased adipose tissue (being overweight) in males may increase likelyhood of finasterde side effects

in Research/Science 30 upvotes 3 months ago

Being overweight may increase finasteride side effects due to higher aromatase activity converting testosterone to estradiol. Maintaining a healthy weight could reduce these side effects.

community Hair theory Scar tissue and Verteporfin

in Chat 26 upvotes 6 months ago

A user suggests that deeper microneedling with Verteporfin injections might help regrow hair in areas with scar tissue, alongside a DHT blocker. Another user explains that hair loss might be due to reduced Wnt/β-Catenin signaling and suggests that treatments like Minoxidil, Finasteride, and microneedling could potentially reverse it.

community Finasteride update/information on Penis/Penile Tissue

in Finasteride/Dutasteride 8 upvotes 1 year ago

Finasteride can reduce DHT in the genitalia, potentially causing side effects like reduced erections and penile fibrosis. Using PDE5 inhibitors like Tadalafil or Sildenafil may help maintain penile health and prevent fibrosis.

community Treatment of Finasteride Induced Gynecomastia (Male breast tissue growth)

in Finasteride/Dutasteride 15 upvotes 4 years ago

Finasteride can cause gynecomastia, which may be reversible by stopping the drug and using selective estrogen receptor modulators (SERMs) like tamoxifen. Lifestyle changes such as weight loss and avoiding alcohol can also help, but surgery may be needed if the condition persists.

community Imo everyone should take serrapeptase for a short extended period to break up scar tissue in their scalp

in Research/Science 1 year ago

Treatments for hair loss, such as Minoxidil, Finasteride and RU58841, as well as using serrapeptase to break up scar tissue in the scalp.

community If half life of fin is 6-8 hours in the blood but 5-6 days in tissue (scalp) why don't people apply topical every 3-4 days to minimize systemic?

in Treatment 28 upvotes 1 year ago

The discussion revolves around the frequency of applying topical finasteride for hair loss treatment. The main question is whether applying it every 4-5 days could still be effective, given that its half-life in the scalp tissue is 5-6 days.

community So did the experiments with verteporfin for hair transplant scarring regrowth fall through?

in Transplants 14 upvotes 1 month ago

Verteporfin reduces scar tissue in hair transplants but doesn't significantly regrow hair follicles. More testing is needed to determine its effectiveness.

community About Verteporfin but not about hair

in Technology 16 upvotes 1 year ago

Verteporfin treatment shows promise for hair regeneration and reducing scar tissue in hair transplants. Some users plan to try verteporfin with hair transplants, and it may also be combined with PRP in future experiments.

community The Big Fat Layer II

in Research/Science 26 upvotes 3 years ago

Hair loss treatment should target dermal white adipose tissue (DWAT) to restore hair follicles. Potential remedies include tocopherol (vitamin E), botox, rosiglitazone, niacin, kojyl cinnamate esters, and ADP355.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 42 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community What’s the science behind 1mg Finasteride 3 X a week being as effective as daily?

in Finasteride/Dutasteride 19 upvotes 1 year ago

The efficacy of taking 1mg finasteride three times a week instead of daily for hair loss, with some users arguing that it is just as effective because finasteride has a long half-life in the scalp tissue and lower doses have been shown to be effective. Other users suggest experimenting with various treatments such as minoxidil and finasteride to achieve best results.

community Injured temple with derma rolling

in Microneedling 2 upvotes 3 months ago

OP injured their temple using derma rolling and tretinoin, causing peeling and potential hair follicle damage. Users suggest the injury might be permanent, possibly resulting in scar tissue where hair won't grow.

community Could microneedling for the next 5 years cause any permanent damage?

in Microneedling 22 upvotes 1 year ago

Microneedling for hair loss and its potential long-term effects. Some users believe it can cause fibrosis and scar tissue if done too frequently or deeply, while others claim it has improved their hair loss when done correctly. There is limited scientific research on the topic.

community Hi beautiful people! I have a question for all the people, that are experienced with microneedling. When I use a dermaroller (1.0), I am bleeding a bit. I use it every two weeks. Is this normal?

in Microneedling 22 upvotes 1 year ago

Microneedling for hair loss causes some bleeding, which is normal. Dermapen is recommended over dermaroller to prevent tissue tearing and adjust depth.

community Tropoelastin injections + verteporfin?

in Research/Science 13 upvotes 1 year ago

The use of tropoelastin injections and verteporfin for hair transplant recipients to help regrow donor area hairs, as well as research done on tropoelastin injections restoring elastin in scarred heart tissue and skin. There are discussions about why it is taking so long to get cosmetic mass produced tropoelastin injectables on the market.

community Verteporfin day 119 update - donor hair regeneration human trial

in Research/Science 148 upvotes 2 years ago

A human trial of verteporfin, a drug that can inhibit wound healing by scarring and promote regeneration of original tissue and hair follicles to provide an unlimited source for hair transplants; people discussed the potential of this drug and how it could be rolled out in mainstream with more doctors getting on board.

community A systematic bro-science review of DHT, 5AR, neurosteroids, sexual health and 5AR inhibitors

in Research/Science 37 upvotes 2 years ago

Hair loss treatments, specifically 5AR inhibitors, can impact neurosteroids and sexual health. The effects of topical fin/dut on tissue-specific DHT levels are unclear.