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TDM-105795 is a potential hair growth stimulant that works differently from minoxidil and could be used alongside it for enhanced growth. It completed phase 2 trials in 2024, with a medium to high chance of release in 2026, but lacks recent updates or phase 3 trial information.

GT20026 is discussed as a potential treatment for hair loss that targets androgen receptors without affecting hormone levels, but it may not promote significant regrowth. It is expected to be available by 2028, with other treatments like Breezula and Clascoterone also mentioned.

The conversation discusses GT20029, a drug in Phase II trials that targets androgen receptors with minimal systemic effects, and TDM-105795, a growth stimulant with a different mechanism than minoxidil that may revive papilla stem cells. Both are potential new treatments for hair loss.

Using topical GHK-Cu 4% has reduced hair shedding, increased hair shaft diameter, and improved scalp health, but no new hair growth was observed. The user continues to use 10% Minoxidil and 1mg oral Finasteride alongside GHK-Cu.

The user has been using oral finasteride for 15 months and oral minoxidil for 6 months, and developed alopecia areata, for which a dermatologist prescribed calcipotriol/betamethasone. The treatment is helping, but the user is experiencing another shedding phase and is concerned about the effects of the steroid cream and the cause of hair loss.

A 23-year-old male experienced an increase in testosterone levels after taking 1 mg of finasteride daily for six months, with no significant side effects reported. Users discussed how finasteride inhibits DHT, leading to increased testosterone, and debated the psychological versus physiological effects of the medication.

Finasteride may decrease free testosterone by increasing SHBG, potentially causing side effects like reduced libido and hormonal changes. Some find it effective for hair loss, while others experience negative effects.

The conversation humorously suggests that elites with full hair are suppressing a hair loss cure to maintain their dating advantage. It mentions treatments like hair systems, hair transplants, and medications such as Minoxidil and finasteride.

Clascoterone 5% solution showed a 539% improvement in hair count compared to placebo, but the actual increase in hair growth is minimal. Users express skepticism about the effectiveness of hair loss treatments.

PP405 may promote short-term hair growth by pushing follicles into the growth phase, but concerns exist about long-term effects due to lack of rest phases. Users discuss various treatments like finasteride, minoxidil, spironolactone, alfatradiol, and investigational drugs like KX-826 and GT20029 for hair maintenance and regrowth.

The conversation discusses the effectiveness of topical tretinoin as a monotherapy for hair loss, with users suggesting it may not be as effective as minoxidil or finasteride. The original poster is considering other options like a phenol peel and is concerned about the risks of derma rolling.

The user is unhappy with the results of their second hair transplant, feeling that grafts were wasted on an already transplanted hairline instead of increasing mid-scalp density. They regret stopping medications like Dutasteride, Minoxidil, and RU58841, which led to significant hair loss, and plan to restart them.

A 37-year-old male resolved scalp folliculitis by adopting a low-histamine diet and taking Vitamin A, Zinc, and Fish Oil, leading to better skin health and thicker hair. He warns about the potential toxicity of excessive Vitamin A intake.

The conversation discusses using 0.5mg dutasteride for hair loss and the decision to switch back to finasteride pills due to insufficient suppression. It highlights the importance of drug formulation and potential issues with absorption or degradation.

A 22-year-old switched from finasteride to dutasteride for hair loss treatment, also using RU58841, and is managing hypothyroidism. Despite ongoing shedding, they report some improvement and plan to continue dutasteride for a year before considering minoxidil.

The conversation discusses the effectiveness of various doses of Dutasteride in reducing scalp DHT and its impact on hair count. Users shared personal experiences with hair loss treatments, including Dutasteride, Finasteride, and Minoxidil, with one reporting significant hair loss reduction using a combination of oral Dutasteride and topical Minoxidil and Finasteride.

The user shared their hair regrowth journey using treatments like dutasteride, minoxidil, microneedling, tretinoin, Nizoral, silica, biotin, and hormone replacement therapy (HRT) with cyproterone and estradiol. They reported substantial hairline improvement and some crown thinning, with hopes for further progress.

The user has been treating hair loss with oral finasteride and minoxidil since September 2025 and is considering a hair transplant due to diffuse thinning. Other users suggest adding a topical treatment and share their own experiences with similar treatments, including oral minoxidil and dutasteride.

OP is using 5% minoxidil and a foligain supplement for hair loss, with blood test results showing high cortisol levels. OP is considering starting finasteride, while another user shares their experience with finasteride and hair loss challenges due to malabsorption issues.

The user is experiencing hair regrowth after two months using topical finasteride, minoxidil spray, and weekly microneedling. They report less hair loss and stronger hair growth.

The conversation discusses using tretinoin as an additional treatment for hair loss alongside minoxidil, with plans to test its effectiveness by applying it to only one side of the scalp. The user intends to start this experiment after using minoxidil for a year.

OP noticed an increase in DHT levels after 5 months of using finasteride and is unsure if the drug is effective or if other factors like stress or vitamins are influencing the results. Users suggest testing the medication for authenticity, consulting a doctor, and possibly trying a different brand or dosage.

Minoxidil may not be effective due to low sulfotransferase activity, and the user considers adding tretinoin to the regimen. They are unsure about the timing and combination with microneedling.

The user is undergoing treatment for hair loss using finasteride, Kenalog injections, and Clobetasol, along with vitamin D and collagen supplements. They are considering additional treatments like minoxidil and microneedling, and there is discussion about whether the hair loss is due to stress, alopecia areata, or a scarring condition like lichen planopilaris.

Adipose-derived stem cell secretome showed significant improvement in hair density and growth, especially when combined with minoxidil, suggesting a synergistic effect. The study had limitations, including a small sample size and potential bias.

Finasteride, dutasteride, saw palmetto, caffeine, spironolactone, acetyltetrapeptides, tea tree oil, hydrocortisone, zinc pyrithione, latanoprost, melatonin, marine protein supplements, PRP, microneedling, and valproate are discussed as treatments for hair loss. DHT reduction and inflammation control are key strategies.

A bodybuilder uses 1400mg testosterone weekly, 400mg equipoise, and GH, with 0.5mg dutasteride daily to stabilize hair loss and manage DHT levels. The user reports no side effects from dutasteride and finds it effective, while also discussing costs and effectiveness of other treatments like RU58841 and minoxidil.

Finasteride has no effect on the user's estradiol levels, and body fat may influence aromatization. The user is on testosterone replacement therapy and uses everyday injections to manage high RBC count, with plans to measure DHT, DHEA-S, and pregnenolone levels.

The user experienced side effects from daily finasteride and reduced the dosage to 0.25mg twice a week while continuing minoxidil. They are considering topical anti-androgens but are concerned about application difficulties and potential side effects.

The user has been taking 1mg finasteride daily for a year with no improvement in hair loss and reports low cortisol levels, sleep issues, and anxiety changes. The conversation includes discussions on the potential effects of finasteride on cortisol and neurosteroids, with suggestions to consult a doctor and consider other factors.