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Did you mean TGF-beta receptor II?

GlossaryTGFBR2 (TGF-beta receptor II)

regulates cell growth and differentiation through TGF-beta signaling

TGFBR2, or Transforming Growth Factor Beta Receptor 2, is a protein that plays a crucial role in cell signaling. It is part of the TGF-beta signaling pathway, which regulates various cellular processes, including cell growth, differentiation, and apoptosis. Mutations or alterations in TGFBR2 can lead to various diseases, including cancer and fibrosis, due to its role in controlling cell behavior.

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community Is this broscience? From More Plates, More Dates

in Research/Science 21 upvotes 9 months ago

The conversation discusses whether finasteride's reduction of DHT and increase in scalp testosterone contribute to hair follicle miniaturization. Some participants argue testosterone does not cause miniaturization, while others suggest that even with reduced DHT, other androgens like testosterone may still contribute to hair loss.

community My hairloss journey. Minox at 34, transplant at 38. No Finasteride

in Transplants 267 upvotes 9 months ago

A person started using Minoxidil at 34 and had a hair transplant at 38, avoiding a straight hairline for a natural look and had 2200 grafts. They began taking Finasteride as a precaution, but Minoxidil did most of the work.

community Why is Minoxidil not enough for hair loss? (No fin)

in Minoxidil 57 upvotes 1 week ago

Minoxidil alone is often insufficient for treating hair loss because it doesn't address the DHT-related cause. Combining it with finasteride, a DHT blocker, is generally more effective.

community Why is nobody studying the difference between donor and balding hair?

in Chat 89 upvotes 6 months ago

The conversation discusses why the difference between donor and balding hair isn't studied more to find a cure for hair loss. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community If Minoxidil Beards are permanent, why should Finasteride be unable to keep Minoxidil Gains on the scalp?

in Minoxidil 104 upvotes 1 year ago

Whether Finasteride can keep alive the hair gained by Minoxidil after quitting it, and why beard hairs are not as susceptible to miniaturization. It is suggested that scalp hair may be dependent on Minoxidil and that DHT could be countered with Finasteride to some extent, but there is no definitive data proving this.

community Helicobacter's concocted serum v1

7 upvotes 5 years ago

A custom-made serum based on double-blind studies for AGA, which includes natural ingredients such as rosemary oil, procyanidin B-2, saw palmetto extract, curcuma aeruginosa, pumpkin seed oil and castor oil. The user has updated their recipe to include apple poly procyanidin B-2 4% concentration and other ingredients before topping it off with Pura d'or serum.

community Does Finasteride Sustain Minoxidil-grown Hairs?

in Finasteride/Dutasteride 8 upvotes 1 year ago

The post discusses whether finasteride can maintain hair growth stimulated by minoxidil. The response indicates that finasteride cannot sustain minoxidil-grown hairs.

community 5 Month's progress on Topical FIN, MIN, Topical Dut, Laser Cap

in Progress Pictures 577 upvotes 3 years ago

User "hemantch" shares 5 months progress using topical Fin, Min, topical Dut, and a laser cap for hair loss. Significant regrowth was noticed after 1 month, and the treatments worked well despite being bald for 10 years.

community HLT Megathread on HMI-115 (key takeaways in comments)

in Research/Science 39 upvotes 1 year ago

HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.

community TGF-Beta. Good or Bad? Help for treatment investment

in Treatment 13 upvotes 2 years ago

TGF-B affects hair growth, both causing stem cell division and death depending on amounts. Amplifica's treatment injects Scube3 to increase TGF-B for hair growth.

community Update about Hair Follicle Glucose Metabolism: New Clinical Data Collection with Ex-President Of American Board Of Hair Restoration Surgery.

in Research/Science 41 upvotes 5 months ago

David Barreto shared that a London-based research group is conducting a 12-month trial for a new nutraceutical treatment for pattern hair loss, designed with Dr. Carlos Puig. The trial aims to provide robust data, with results expected in 1-2 years, potentially representing a significant advancement since finasteride’s introduction in 1997.

community Taurine supplements work for hair growth?

in Product 8 upvotes 7 months ago

The conversation discusses taurine supplements for hair growth, highlighting their potential to reduce DHT and improve hair health. A user comments that people often try alternatives to finasteride.

community Tretinoin potentially can make hair loss worse ?

in Research/Science 6 upvotes 2 years ago

Tretinoin may worsen hair loss by inducing premature hair follicle regression. It can be used with minoxidil to increase absorption but should not be used alone.

community Pirfenidone - The answer to fibrosis and baldness

in Treatment 19 upvotes 3 years ago

Pirfenidone is suggested to treat fibrosis and baldness by blocking inflammation markers and reducing collagen. It is also available as a gel for scar removal.

community Peptides that Stop Hair Loss? | In-depth Literature Review Video

in Research/Science 74 upvotes 5 months ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community My results after starting Dutasteride + oral minoxidil.

in Progress Pictures 45 upvotes 1 year ago

A user who, after experiencing hair loss 4 years ago, used topical minoxidil for some good results. Two years later, finasteride was added with limited success. After consulting a dermatologist, dutasteride and oral minoxidil were introduced to the treatment plan; after two months of use, there have been notable improvements in both density and quality of hair as well as less shedding.

community Scientists have finally found the potential ‘cure’ for baldness

in Research/Science 2 years ago

A new study that found a single chemical could potentially be responsible for hair loss, and the potential to use this discovery to stimulate hair growth. The conversation also includes various treatments such as Minoxidil, Finasteride, RU58841, microneedling, DUT, and Botox for hair loss.

community Possible topical option for preventing BDNF-related hair loss

in Research/Science 7 upvotes 1 year ago

The conversation discusses hair loss linked to BDNF-increasing nootropics like Semax and Lions Mane. Suggested topical treatments include capsaicin, beta-glucan, and ginseng to counteract TGF-B activation.

community A concise, easy-to-understand post on Androgenic Alopecia theory and its practical applications

in Research/Science 92 upvotes 2 years ago

The mechanism of Androgenic Alopecia and practical applications of treatments like Minoxidil, Finasteride, RU58841, dermarolling, scalp massages, anti-fungals, progesterone, estrogen, PPAR-γ activators, reducing oxidative stress, and scalp exercises. It explains why DHT is important in AA and how other factors might be involved such as hypoxia, increased DKK-1 expression, morphological changes to the scalp, skull growth during childhood/puberty, and blood flow.

community dunno if it's growing anything but it's making my scalp red

in Technology 181 upvotes 1 year ago

Hair loss and potential treatments, primarily focusing on Finasteride and Minoxidil. Other solutions discussed include PRP, dermarolling, LLP, and scalp tension relief.

community Hairloss - what hormones to check?

in Finasteride/Dutasteride 10 upvotes 1 year ago

The user is concerned about hair loss despite using oral finasteride, oral minoxidil, and topical minoxidil. They are seeking advice on additional blood tests to identify potential causes.

community The Effect of Intradermal Botox on Androgenetic Alopecia and Its Possible Mechanism (Journal of the American Academy of Dermatology (2020)

in Treatment 12 upvotes 4 years ago

Intradermal botulinum toxin (BTX) injections effectively treat androgenetic alopecia (AGA) by inhibiting TGF-β1 secretion from hair follicles. Further research and long-term follow-up are needed to confirm these findings.

community 2 years dutasteride + 1 year minox

in Progress Pictures 41 upvotes 1 year ago

A hair loss regimen that includes oral dutasteride and topical minoxidil, as well as occasional dermapen treatments; the user inquires about when they noticed most regrowth.

community A meta analysis of 18 popular hair loss treatments. An 2022 guide on efficacy. From finasteride and minoxidil to caffeine shampoo, saw palmetto and biotin. 96 Scientific References included.

in Research/Science 101 upvotes 2 years ago

Most hair loss treatments are ineffective; only finasteride, dutasteride, and minoxidil show effectiveness.

community Physio-metabolic method (antiandrogen, minoxidil, leg training and cold)

in Treatments 309 upvotes 6 months ago

The method combines finasteride, minoxidil, intense leg exercises, and cold exposure to treat androgenetic alopecia. It aims to boost metabolism and reduce androgenic effects, enhancing hair growth.

community 0.5mg Dutasteride promotes more “regrowth” than 5mg oral Minoxidil

in Research/Science 117 upvotes 10 months ago

Dutasteride promotes more hair regrowth than Minoxidil. Users discuss combining treatments for better results and share personal experiences with side effects.

community Proposed new pathogenesis model for androgenetic alopecia (AGA)

in Research/Science 8 upvotes 1 year ago

The conversation discusses a new model for understanding androgenetic alopecia (AGA), linking it to dietary and lifestyle factors similar to PCOS, and highlighting the role of DHT, vascular damage, and inflammation. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community Hair loss treatments rated (by gpt-4)

in Research/Science 253 upvotes 1 year ago

Rating treatments for hair loss, with the help of GPT-4, according to efficacy, evidence and tolerability; a combination of chemicals from research papers, custom compounds, and some suggestions from other users were included.

community No Improvement on Finasteride.

in Treatment 1 year ago

Attempting to treat hair loss with Finasteride, and other treatments such as Minoxidil, RU58841, and DUT were suggested.

community 12 mo update: oral (dut, min), topical (RU, min), microneedling

in Progress Pictures 353 upvotes 1 year ago

A user's 12 month update on treatment for hair loss, which include oral dutasteride and minoxidil, topical RU88541 and minoxidil, microneedling with hyaluronic acid and FinDuta, experiencing no side effects, positive results and inspiring other users.