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GlossaryTransglutaminase (TGase)

enzyme that cross-links proteins, crucial for hair strength

Transglutaminase, often abbreviated as TGase, is an enzyme that catalyzes the formation of covalent bonds between proteins, specifically by linking the amino acid glutamine to lysine. This process is crucial for various biological functions, including blood clotting, skin formation, and hair follicle development. In the context of hair, transglutaminase helps strengthen the hair shaft by cross-linking keratin proteins, contributing to hair's structural integrity and resilience.

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community Goth mohawk is fading, I can’t keep with minoxidil and can’t get finasteride perscription

in Minoxidil 140 upvotes 3 months ago

A user is experiencing accelerated hair loss and is struggling to maintain their mohawk. They are seeking alternatives to Minoxidil and Finasteride, considering a hair transplant, and looking for a doctor in Berlin who can prescribe Finasteride.

community Little Update - Min 6 Months and Fin 5 Months

in Progress Pictures 263 upvotes 7 months ago

The user shared a 6-month progress update on hair regrowth using Minoxidil and 5 months of Finasteride, along with a hair transplant of 4,200 grafts. Commenters reacted positively, discussing the effectiveness of these treatments and the impact on self-image.

community Bald groom beaten over fake hair.

in Satire 881 upvotes 1 year ago

A bald groom was beaten by the family of the bride for wearing a wig. The conversation discusses the cultural stigma around baldness in India and the consequences of deception in arranged marriages.

community “Guys, am I norwood 3? Should I take fin?”

in Satire 446 upvotes 1 year ago

Hair loss, and treatments such as finasteride and oral minoxidil being discussed. Some people shared stories of their personal experiences while others gave humorous replies.

community New potential hair loss treatment (news release)

in Treatment 186 upvotes 4 years ago

New potential hair loss treatment uses molecules from hairy moles to stimulate follicle growth. Topical solution requires less frequent application, like Botox injections a few times per year.

community Wasn't Breezula supposed to post some results soon?

in Question 18 upvotes 5 years ago

The conversation is about expecting results from Breezula, a hair loss treatment, with no new information released as of April 1st. Some joked it's just onion juice, while another comment suggested a conspiracy to cause baldness.

community My hair journey: 2017 through the present

in Progress Pictures 504 upvotes 2 months ago

A user shared their hair loss journey from 2017 to 2024, detailing the use of finasteride, minoxidil, dutasteride, supplements, and dermarolling. They experienced significant hair loss after stopping finasteride in 2017, saw some regrowth after resuming treatments in 2023, and are considering a hair transplant.

community 16 months or so. Back from the dead. Age 41

in Progress Pictures 555 upvotes 5 months ago

A user shared their 16-month hair regrowth progress using oral and topical minoxidil, dutasteride, derma rolling, and occasional keto shampoo. The conversation includes positive reactions and jokes about their impressive results.

community The worst thing about hair loss? Rant here!

in Chat 125 upvotes 5 months ago

Hair loss deeply affects self-esteem and mental health. Treatments mentioned include hair transplants, Minoxidil, Finasteride, and RU58841.

community Is there any new drug that looks promising ?

in Research/Science 25 upvotes 8 months ago

The conversation discusses GT20029, a drug in Phase II trials that targets androgen receptors with minimal systemic effects, and TDM-105795, a growth stimulant with a different mechanism than minoxidil that may revive papilla stem cells. Both are potential new treatments for hair loss.

community Is it normal to lose body hair on finasteride?

in Research/Science 11 upvotes 8 months ago

Finasteride can cause body hair loss, which is normal. It may also be due to disease or nutrient deficiencies.

community My dad 61y/o healed from full bald to full head of hair

in Finasteride/Dutasteride 175 upvotes 10 months ago

A user's 61-year-old father regained a full head of hair after four years on dutasteride for his prostate and five months of weight loss and exercise. The user decided to switch from finasteride to dutasteride and continue exercising, inspired by his father's results.

community Finally progress! - 4 month on 1.25mg FIN (daily) + MIN + Dermarolling

in Progress Pictures 199 upvotes 11 months ago

The conversation discusses a user's progress after 4 months of using 1.25mg finasteride daily, minoxidil, and dermarolling to treat hair thinning, particularly on the sides and crown. The user believes finasteride made the most difference, and they share tips on managing hair loss and tracking progress.

community Finasteride vs Dutasteride, some helpfully info I put together as a physician

in Finasteride/Dutasteride 18 upvotes 11 months ago

The conversation discusses the pros and cons of dutasteride for male pattern baldness, with a focus on its long half-life. The user, a physician, also mentions that switching from finasteride to dutasteride can cause temporary hair loss until dutasteride reaches effective levels or accelerates the hair cycle.

community Why the fu*k do people behave like this?

in Chat 385 upvotes 1 year ago

People making comments on others' hair loss, and the different strategies used to deal with it. Treatments mentioned include finasteride and minoxidil.

community Has anyone had success Dermarolling without Min?

in Microneedling 12 upvotes 3 years ago

The conversation is about the effectiveness of Dermarolling for hair loss without using Minoxidil. Some people consider using peppermint oil as an alternative.

community Success sttory – 22 to 27

in Progress Pictures 4 years ago

A user's success story of improving their hair loss with treatments that include finasteride, dutasteride, minoxidil, nizoral, and dermastamping; other products that have been tried with varying results; and potential side effects.

community The Finasteride Shed is real.

in Finasteride/Dutasteride 159 upvotes 2 months ago

Increasing finasteride dosage can cause significant hair shedding initially. Users suggest adding minoxidil or switching to dutasteride for better results.

community 3 months into treatment... I'm I hyper responsive?

in Is this regrowth? 1211 upvotes 3 months ago

A 26-year-old male started minoxidil treatment for male-pattern baldness and saw significant regrowth in three months. He is considering finasteride but is hesitant due to potential side effects.

community Holy shit. Verteporfin may actually be the cure

in Research/Science 1015 upvotes 1 year ago

The post and conversation discuss Verteporfin's potential as a hair loss treatment. It's shown promise in regrowing hair after transplants and might be effective with microneedling.

community If anyone else feels like they’re too far gone for a hair transplant or can’t tolerate finasteride, I highly recommend trying a hair system! You have nothing to lose and it can change your life. I understand the worries and concerns, as I was very nervous/scared before taking the leap. AMA

in Hair Systems 394 upvotes 1 year ago

The conversation discusses the use of hair systems as a solution for hair loss. Users share their experiences, highlighting the natural look, confidence boost, and maintenance requirements of hair systems, while also addressing concerns about cost, stigma, and potential drawbacks.

community The crazy thing with diffuse thinning is one day you think you have no hair loss, and another day you think you have no hair

in Chat 398 upvotes 1 year ago

The post and conversation discuss the unpredictable nature of diffuse thinning, a type of hair loss. Users share personal experiences, with some mentioning treatments like oral finasteride and toppik, and the need for patience with these treatments.

community New Treatments, and a Huge Group Buy with Lots of Research

in Research/Science 109 upvotes 1 year ago

A user is organizing a group buy for various compounds aimed at reversing hair loss and gray hair, and improving brain health and fat loss. The user has developed a treatment plan based on extensive research and is inviting others to participate, with the option to choose only the compounds they need.

community How would you start your hairloss battle if you were 16 y.o?

in Treatment 15 upvotes 1 year ago

A 16-year-old experiencing hair loss seeks treatment advice. They decide to start with Serioxyl, Ketoconazole shampoo, and Eucapil, considering Minoxidil and Finasteride for later use.

community Shrooms have done more for my hair loss than all of my hair supplements/medications combined.

in Satire 408 upvotes 1 year ago

Finding acceptance of hair loss through psychedelics, and the potential benefits of shrooms. Discussions include sharing experiences with minoxidil, finasteride, nutrafol, laser therapy, micro needling, as well as mental health concerns such as depression, suicidal thoughts, and self-esteem.

community Why Cant we just find an effective androgen receptor antagonist that works locally on the scalp?

in Research/Science 1 year ago

Researching and developing an effective local antagonist to block the androgen receptors for hair loss, as opposed to using DHT synthesis inhibitors that lower serum DHT levels. Several treatments such as CosmeRNA and Pyrilutamide are currently in development or undergoing trials.

community Finasteride only 9 months update

in Progress Pictures 474 upvotes 2 years ago

A 25-year old user's progress with only finasteride in treating their hair loss, and other users suggesting minoxidil and dermarolling as additional treatments.