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GlossaryAndrogen Insensitivity Syndrome (Testicular Feminization Syndrome)

genetic condition causing resistance to male hormones in XY individuals

Androgen Insensitivity Syndrome (AIS) is a genetic condition where a person who is genetically male (with one X and one Y chromosome) is resistant to male hormones called androgens. As a result, the person has some or all of the physical traits of a woman, but the genetic makeup of a man. This can lead to a range of physical manifestations, from completely typical female external genitalia to ambiguous genitalia, depending on the degree of insensitivity.

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community Is this true? Is long term taking fin harmful to the liver?

in Chat 127 upvotes 11 months ago

The conversation discusses whether long-term use of finasteride (Fin) is harmful to the liver, with various opinions on side effects and comparisons to other substances. Specific treatments mentioned include finasteride, minoxidil (Min), and RU58841 (RU).

community 5 months on Spiro and 6 weeks on oral Monoxidil. Beyond thrilled with the results so far

in Female 190 upvotes 4 years ago

Treatments for hair loss, specifically the use of Spironolactone (Spiro) and oral Minoxidil, as well as Finasteride and RU58841.

community FtM: "Aggressive Regemin - Recovery From Norwood-6.5" Minoxodil/Estradiol valerate/Spironolactone. (What will happen in the worst case if CIS male go this way for a year?)

in Progress Pictures 55 upvotes 3 years ago

User "Ant1pal" shares progress pictures of hair regrowth using Minoxidil, Estradiol valerate, and Spironolactone. Users discuss potential side effects and the possibility of localizing estrogen to hair follicles for better treatment.

community Minoxidil results in 3 months after stopping fin

in Is this regrowth? 467 upvotes 6 days ago

The user stopped finasteride due to testicular aches and switched to minoxidil, seeing positive results in three months. They are considering topical finasteride but are cautious because of past side effects from oral use.

community Finasteride influence on other hormones

in Finasteride/Dutasteride 8 upvotes 3 years ago

Finasteride can affect hormone levels, potentially causing symptoms like puffy nipples and testicular pain, and may result in elevated prolactin and high testosterone. The user is seeking interpretation of these changes after taking finasteride.

community Absolute nightmare from a week of finasteride.

8 upvotes 5 years ago

A user experienced severe side effects, including erectile dysfunction and testicular pain, after taking finasteride for hair loss. They recommend sticking to minoxidil and biotin and avoiding finasteride due to potential risks.

community 3 months update on meds post HT

in Progress Pictures 111 upvotes 1 month ago

The user started using 1mg finasteride and Regaine foam post-hair transplant, noticing significant hair growth at three months. They experienced testicular cramps as a side effect but no other issues, and are considering microneedling for further improvement.

community Probably progress in about 4 months

in Progress Pictures 47 upvotes 9 months ago

The user started using minoxidil and finasteride for hair loss but stopped minoxidil due to scalp issues and tinnitus. They experienced testicular pain, shedding, and side effects like itchy chest and watery sperm, but noticed considerable hair regrowth except at the temples.

community Fin bad responder? My experience

in Finasteride/Dutasteride 2 upvotes 3 years ago

The user experienced side effects from ecklonia cava similar to those reported with finasteride, including depression, brain fog, anxiety, and testicular pain. Despite these issues, the user is still considering using topical finasteride in the future.

community 7 months progress. fin 1.25 mg, oral min 2.5 mg, keto shampoo, micro-needling once per month. M/32

in Progress Pictures 82 upvotes 8 months ago

A user shared a 7-month hair loss treatment progress using finasteride 1.25 mg, oral minoxidil 2.5 mg, ketoconazole shampoo, and monthly micro-needling, noting denser hair and improved quality but no significant regrowth. They experienced mild testicular discomfort and heart palpitations, considering switching to topical minoxidil to avoid side effects.

community Half a year finasteride pill a day and minoxidil once a day and dermacollar once a week

in Progress Pictures 250 upvotes 9 months ago

The user has been taking a daily finasteride pill, applying minoxidil once a day, and using a dermaroller once a week for six months to treat hair loss, showing progress with their treatment. Some users discussed side effects like testicular discomfort with finasteride, which may subside over time.

community 42M 5 months (topical fin, oral min)

in Progress Pictures 35 upvotes 1 year ago

A 42-year-old man is using topical finasteride, oral minoxidil, microneedling, ketoconazole shampoo, and various oils for hair loss treatment and is happy with the improvements after 5 months. He experienced mild side effects from finasteride, including temporary testicular pain and changes in libido, but no side effects from minoxidil.

community 11 Months Topical Fin 0.3%+Min 6% daily, Last 2 Months Added Min 5% Foam at Night, Late 30s Male Progress

in Progress Pictures 186 upvotes 1 year ago

The user "_Mad_Jack_" shared their progress pictures of using topical finasteride and minoxidil for 11 months. They experienced good hair retention and increased overall hair count, but no regrowth of the hairline. They are considering switching to oral finasteride and microneedling for better results. Testicular pain was a side effect experienced during the treatment. Another user mentioned getting a hair transplant to cover their crown.

community Fin + Min + Niz + Microneedling

in Is this regrowth? 18 upvotes 9 months ago

The conversation discusses hair regrowth using finasteride, minoxidil, ketoconazole shampoo (Nizoral), and microneedling as treatments. Users are sharing their experiences and results with these specific hair loss treatments.

community personal progress (~8-9months) with fin(1.25mg)/min/needling/niz

in Progress Pictures 571 upvotes 2 years ago

A user's personal hair loss progress with treatments, including finasteride (1.25mg), minoxidil, needling, and Nizoral; and advice from other users on how to perform the needling correctly.

community Shedding on pyri (KX-826) is this normal?

in Update 8 upvotes 3 months ago

A user experienced increased shedding after adding KX-826 to their long-term finasteride and minoxidil regimen. Another user reported mild side effects from KX-826, such as stomach and testicle pain.

community Mechanism of action of alfatradiol (17 alpha estradiol)

in Research/Science 6 upvotes 6 months ago

The conversation discusses the mechanism of action of alfatradiol (17 alpha estradiol) in treating hair loss. It explores theories that it either inhibits 5 alpha reductase to prevent T->DHT conversion or aromatizes scalp T into 17-alpha-estradiol to save hair.

community 2 months of topical minoxidil (5%) use and there is a shadow now!

in Transgender 192 upvotes 1 year ago

The post discusses the user's experience with topical minoxidil (5%) for hair loss, showing some improvement after 2 months. Suggestions from others include keeping the hair shorter on the sides and back, adding finasteride for better results, and considering a shaved head look, though the latter was debated for its femininity.

community Min/Fin/Dut and Topical Biotin progress pics

in Progress Pictures 328 upvotes 2 years ago

User tried Min/Fin/Dut and Topical Biotin for hair loss. Some say it's not working, while others appreciate the progress.

community Discussion on Finasteride and life.

in Chat 164 upvotes 2 months ago

Finasteride can aid hair regrowth but may cause side effects like depression and sexual dysfunction. Users discuss experiences with finasteride, minoxidil, and RU58841, highlighting varied responses and the importance of informed treatment choices.

community Anyone ever get a shedding phase on RU58441

in Chat 6 upvotes 2 months ago

The user experienced increased hair shedding after using RU58841 for two months, but found relief from scalp itchiness. Other users shared similar shedding experiences and discussed side effects like joint pain, while also mentioning the use of finasteride and minoxidil.

community Finasteride works like viagra for me

in Finasteride/Dutasteride 153 upvotes 4 months ago

Finasteride increased libido for some users, with effects normalizing after a few weeks to months. Other treatments mentioned include Dutasteride and Minoxidil.

community Just found a little hard lump under my left nipple, it’s over

in Finasteride/Dutasteride 12 upvotes 5 months ago

A user experienced a hard lump under their nipple and increased hair loss after four months of finasteride. They are concerned about the lump and plan to stop the treatment.

community A science based addition to your hair loss routine

in Research/Science 23 upvotes 5 months ago

Blocking the Mitochondrial pyruvate carrier and using aldose reductase inhibitors like Indian gooseberry and berberine may help with hair growth. Magnesium can also be added to increase NADPH.

community for those who had high levels of testo and estradiol after start fin/dut: did it comeback to baseline or normal levels?

in Finasteride/Dutasteride 8 upvotes 6 months ago

A user experienced increased testosterone and estradiol levels after starting finasteride/dutasteride and is asking if these levels will return to normal over time. The conversation focuses on whether these changes are temporary.

community I can't believe what I'm seeing (aged 31, NW1, diffuse thinning, nearly 5 months on Finasteride 0.75mg MWF, exact same haircuts 6 months apart)

in Is this regrowth? 94 upvotes 6 months ago

A 31-year-old with diffuse thinning experienced significant hair regrowth after nearly 5 months on Finasteride 0.75mg MWF. Despite initial side effects like testicle pain and reduced sex drive, these issues resolved, and positive effects included reduced nighttime urination and scalp itching.

community 3 months only fin + vitamins update

in Progress Pictures 90 upvotes 8 months ago

User shared a 3-month update on using finasteride and vitamins (Zinc, D3, B12, Magnesium) for hair loss. Progress pictures show improvement, and other users commented on their experiences and asked about specific vitamins.

community im gonna be excited and want to share these news with you but dont be negative

in Product 26 upvotes 9 months ago

The user is excited about an upcoming update for GT20029, expected in March. They express frustration with the negativity on Reddit.

community Update: 4 Month progress on Fin/Min plus dermaroller

in Progress Pictures 559 upvotes 11 months ago

A user shared a 4-month update on their hair regrowth progress using finasteride, minoxidil, a dermaroller, ketoconazole shampoo, multivitamins, and biotin, and received positive reactions and inquiries from others. They also mentioned lifestyle changes such as quitting creatine, alcohol, and smoking, which may have contributed to their success.

community People need to start accepting that only medical therapy (Fin/Dut) can save your hair in the long run.

in Treatment 112 upvotes 11 months ago

Minoxidil can regrow hair but doesn't address the underlying issue of DHT, leading to continued hair loss. Users discuss their experiences with finasteride and dutasteride, mentioning side effects, personal outcomes, and alternatives like microdosing topical finasteride.