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GlossarySystemic Antiandrogens

medications that reduce male hormone effects body-wide

Systemic antiandrogens are medications that reduce the effects of androgens (male hormones) throughout the entire body. They are commonly used to treat conditions like androgenic alopecia (hair loss), prostate cancer, and severe acne by blocking androgen receptors or inhibiting androgen production. These therapies can be crucial for managing hormone-related disorders and are often referred to as systemic anti-androgen therapy.

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community The story of RU58841/ PSK3841

Typical-Promise-3001 in Research 622 upvotes 5 months ago

RU58841, a potential hair loss treatment, was not commercialized due to marketability issues and lack of long-term safety data. Concerns about its formulation and delivery methods further complicate its use.

community Protac degradation of the androgen receptor in mice shows good efficacy and no systemic drug could be found

Additional_Rough_968 in Research/Science 47 upvotes 2 years ago

The efficacy of degrading the androgen receptor through dermal application in DP cells, a delivery system for topical drugs that involves dissolving microneedles, and rosemary oil as an alternative anti-androgen.

community Is there a consensus on RU these days? Pyril turned out to be a bust right?

Protectereli in Research/Science 16 upvotes 10 months ago

The conversation discusses the effectiveness and safety of hair loss treatments, specifically RU58841 and Pyrilutimide (Pyril), with users sharing that Pyril was no more effective than a placebo and expressing concerns about the safety of RU58841 based on personal experiences and the lack of pharmaceutical interest.

community Kintor Pharma Announces Completion of Patient Enrollment in Phase II Clinical Trial of GT20029 for Treatment of Androgenetic Alopecia in China

dannar2003 in Research/Science 88 upvotes 1 year ago

Kintor Pharma completed patient enrollment for a Phase II trial in China for GT20029, a potential new treatment for hair loss. Some believe GT20029 could replace finasteride if effective, while others discuss finasteride's limited efficacy and potential underreported side effects.

community Extreme regimen and still miniaturized hairs. AGA is just impossible to beat.

AdriTexX in Insane 34 upvotes 2 years ago

A user's extreme regimen for hair loss, which includes taking oral and topical medications such as minoxidil, dutasteride, cyproterone acetate and bicalutamide, but still experiencing miniaturization. Suggestions were made to try other treatments such as RU58841 and Pyrilutamide, while also considering mental health treatment and advice on lookmaxxing.

community Finasteride/dut. causes NAFLD,IR,diabetes,kidney dysfunction is it correct.

PrizeSandwich4094 in Finasteride/Dutasteride 139 upvotes 1 year ago

Hair loss discussion mentions treatments like Finasteride, Dutasteride, and Minoxidil. Users share experiences, side effects, and advice on using these treatments.

community If RU58841 is such an effective anti androgen

ConsistentLab193 in Research/Science 46 upvotes 1 year ago

RU58841 is discussed as a topical anti-androgen for hair loss, but its effectiveness and safety are not well-documented, leading to mixed opinions and experiences among users. Some combine it with finasteride, but concerns about side effects and lack of FDA approval limit its popularity.

community Can we have a thread that summarizes all treatments options in addition to the big 3 which we have some evidence for, their mechanism of action and whether they can be combined with the big 3(other than dermarolling)?

confusedLeb in Treatment 55 upvotes 6 years ago

The conversation discusses hair loss treatments beyond the commonly known three, focusing on separating effective treatments from myths. Dutasteride and low-dose oral Minoxidil are mentioned as having clinical evidence for increasing hair counts, but with potential side effects.

community PYRILUTAMIDE KX-826 experience

Outrageous_Fan7685 in Research/Science 96 upvotes 2 years ago

A user's experience with the hair loss treatment Pyrilutamide KX-826, which has resulted in some side effects and shedding. The conversation also includes advice for baseline pictures and trying treatments for at least 6 months.

community In three years time we'll still be in roughly the same place with regardless to treatments as we are now - and it will be the fault of all of us.

robbieuk83 in Chat 16 upvotes 3 years ago

User discusses frustration with hair loss treatments and lack of progress. Emphasizes importance of measuring blood hormone levels to understand treatment effectiveness and side effects.

community If Ru58841 was an FDA approved medication and known to be safe would you recommend it before finasteride?

Mullentheworm in Product 7 upvotes 1 year ago

The conversation discusses whether RU58841, if FDA approved and safe, would be recommended over finasteride for hair loss. Specific treatments mentioned include RU58841, finasteride, and minoxidil.

community The hardest hair protocol ever!

onajLikZnasGa in Research/Science 10 upvotes 2 years ago

The user is using RU58841, finasteride, dutasteride, and minoxidil to slow down aggressive hair loss but is still experiencing hair shedding due to high testosterone levels. They plan to use ostarine to lower testosterone and prevent hair loss while maintaining muscle mass, and will continue using the other treatments.

community Testosterone and hair loss seeming irrelevance

throwaway1003333 in Research/Science 79 upvotes 1 year ago

The conversation is about the role of testosterone in hair loss and the effectiveness of different treatments. The conclusion is that DHT is the main culprit for hair loss, and finasteride has been proven to work long-term in maintaining and regrowing hair. Testosterone may have a minor effect, but it is not the primary cause of hair loss.

community 8.5 month progress of min/fin/RU

sublocade9192 in Progress Pictures 62 upvotes 3 years ago

The conversation discusses an 8.5-month progress of using Minoxidil, Finasteride, and RU58841 for hair loss. People are complimenting the user on the significant improvement in hair thickness.

community Binding affinity of pyrilutamide!

alexffy66433 in Update 171 upvotes 2 years ago

Pyrilutamide, a nonsteroidal antiandrogen drug under development for the potential treatment of androgenic alopecia. The conversation discusses its binding affinity to the androgen receptor and the timeline for possible availability after trials are completed in the United States and China.

community Saved hairline. 2.5 year transformation. 2.5 years of 0.5mg finasteride + RU (1.5g spread over 2.5 years)

Snoo-68513 in Progress Pictures 500 upvotes 2 years ago

A user's 2.5 year transformation of using 0.5mg finasteride and RU58841 to combat hair loss, with the possibility of increasing the RU for further regrowth.

community to all people who cannot tolerate anti androgens (loe dose topical fin, pyrilutamide, CB) i am getting desperate, looking for a solution

Additional_Rough_968 in Research/Science 13 upvotes 2 years ago

The user tried Minoxidil without success, and Finasteride worked but caused sexual side effects even at a very low dose. They are seeking alternative treatments for hair loss as they cannot tolerate anti-androgens and are also in therapy for mental health.

community I Get Side-Effects from Anti-Androgens

_phenomejon in Finasteride/Dutasteride 9 upvotes 4 years ago

Someone looking for solutions to their hair loss, who has tried and failed to tolerate anti-androgen treatments such as finasteride, CB-03-01, RU58841, and Eucapil. The user is seeking advice and understanding of their extreme sensitivity to these treatments.

community Insane MTF recovery 18 months blocking androgens

Mindless-Ad-7102 in Progress Pictures 145 upvotes 1 year ago

Hair loss recovery using estrogen and anti-androgen treatment for 18 months showed significant improvement. However, results vary and alternative treatments like RU58841 and Dutasteride may work without systemic feminization.

community Dutasteride 1 year regression. Depressing. (With pictures for proof)

Nonstopshedder in Progress Pictures 14 upvotes 1 year ago

A user shared their experience of hair loss progression after one year on dutasteride, expressing disappointment with no improvement and considering other treatments like RU58841. Other users offered mixed responses, some seeing no change, others suggesting the hair loss might have been worse without treatment, and discussing the role of testosterone and DHT in hair loss.

community 15 years of finasteride/minoxidil

Oxbow8 in Update 194 upvotes 9 months ago

A user shared a 15-year experience using minoxidil and finasteride for hair loss, stating that despite never missing a dose, their hairline continued to recede slowly. Other users suggested that the hair loss might be exacerbated by the use of steroids and recommended considering other treatments like dutasteride and RU58841.

community Pyrilutamide update number 2 - 2 week use

ljammm in Update 174 upvotes 2 years ago

An update on the use of Pyrilutamide, a new drug for hair loss, which has resulted in no shedding or testicle ache; other users have questioned the science behind this and shared their own experiences with Finasteride, Minoxidil, and microneedling.

community Maintaining hair until Breezula without Fin

hairgodshavemercy in Treatment 6 upvotes 4 years ago

A 21-year-old male experienced side effects from topical finasteride and is seeking alternative treatments to maintain hair until Breezula is available. He is considering using minoxidil, Nizoral, micro-needling, and vitamin D supplementation, and may try CB or RU58841 if necessary.

community Ultimate Hairloss Flowchart (for beginners)

rhughes490 in Treatment 247 upvotes 1 year ago

The conversation discusses a hair loss flowchart for beginners, with mixed opinions on its effectiveness. Treatments mentioned include minoxidil, finasteride, dutasteride, microneedling, and vitamins.

community Dermarolling is a bit sad innit?

PCPooPooRace_JK in Microneedling 232 upvotes 3 years ago

Hair loss treatments discussed include dermarolling, minoxidil, finasteride, and RU58841. Some users find dermarolling sad, while others mention the complexity of biological systems and limited research funding for hair loss.

community Estrogen is an anabolic for scalp hair, if you mix it with growth stimulants such as oral minoxidil. All we need is an artificial SARM-estrogen that will work only with hair and will be invisible for the rest of the body + some next level AA only for hair – goodbye hair transplant industry

Ant1pal in Transgender 137 upvotes 3 years ago

Hair loss discussion mentions using estrogen mixed with growth stimulants like oral minoxidil for scalp hair growth. Idea proposed for an artificial SARM-estrogen that only affects hair without body side effects.

community Kintor has announced the results for their human Phase I trials of GT20029

poiuytrewq_poiuytrew in Research/Science 253 upvotes 2 years ago

The conversation discusses the potential of a new hair loss treatment, GT20029, which may prevent hair loss by destroying androgen receptors on the scalp. Users express hope for the treatment's success and speculate on its usage routine, effectiveness, and possible side effects.

community Why are more people not using RU58841

sylarrrrr in Product 14 upvotes 10 months ago

People are not using RU58841 for hair loss because it's not FDA approved, lacks long-term safety data, and is difficult to obtain and verify. They prefer FDA-approved treatments like minoxidil, finasteride, ketoconazole shampoo, and microneedling.

community Are these all the anti androgen products?

Swimming-Assistance9 in Treatment 6 upvotes 1 year ago

The conversation lists hair loss treatments including finasteride, dutasteride, RU58841, pyrilutamide, breezula, and fluridil, and suggests ketoconazole as another option. Some users warn against using certain treatments like cyproterone acetate, bicalutamide, and spironolactone due to their strong anti-androgen effects and potential impact on masculinity.

community Diagnosed with female pattern hair loss as a male with recent aggressive loss. Preemptively mourning the only part of myself I’ve ever come close to loving. Lost all motivation to do anything with my life.

AesopsTable2 in Progress Pictures 271 upvotes 1 year ago

The conclusion of the conversation is that the user should consider using treatments such as finasteride, minoxidil, and RU58841 to potentially reverse their hair loss. Other suggestions include using hair loss concealers and maintaining a healthy diet.