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      community Similar 5ar inhibitors to fin?

      5 years ago
      Natural vitamins like pumpkin seed oil, saw palmetto, and ecklonia cava are discussed for their potential to lower DHT levels. They may work similarly to finasteride but are significantly weaker.

      community Life Extension - Hair Growth for Men

      1 year ago
      A new supplement for hair growth combines black rice, prickly pear, and saw palmetto, showing promising results in increasing hair density and reducing hair loss. The supplement is considered a drug-free alternative to traditional treatments like minoxidil and finasteride.

      community Castor oil home brews and regimens?

       4 upvotes 8 years ago
      Using castor oil, coconut oil, rosemary, tea tree oil, peppermint oil, and other essential oils for hair loss prevention. Emu oil and derma rollers are also discussed, with caution advised for coconut oil's comedogenic properties and taking castor oil orally.

      community Jxl069 (pp405 api) week 8 update

       205 upvotes 1 year ago
      The user shared minimal results from using JXL-069 for hair loss, noting a slight lengthening of vellus hairs and plans to switch to a prodrug variant due to limited effectiveness. They also mentioned using finasteride and minoxidil, which have plateaued in results.

      community Where to find ethanol for RU powder

       5 upvotes 4 years ago
      The conversation is about finding ethanol in California for mixing with RU58841 for hair loss treatment. Users suggest alternatives like high-proof alcohol from liquor stores or purchasing lab-grade ethanol online.

      community What's going on with hmi115? The Phase 2 was concluded Nov2024 but no news

       13 upvotes 9 months ago
      Hmi115, a prolactin receptor blocker, showed promise for hair growth, but results from Phase 2 trials have not been published. ABS-201, an AI-based analog, is expected to begin trials in December 2025, while commercialization of treatments like PP-405 is anticipated around 2027.

      community Shedding increase from pumpkin seed oil - dread shed or time to stop?

      in Female 8 months ago
      A user experienced increased hair shedding after taking pumpkin seed oil for 4 weeks and is unsure if it's a "dread shed" or if the oil isn't suitable. They cannot tolerate anti-androgens like spironolactone and finasteride due to side effects and are seeking advice on whether to continue with pumpkin seed oil.

      community Sanguisorba Officinalis Root Extract, and other FGF-5 inhibitors?

       4 upvotes 9 years ago
      The conversation discusses the potential of Sanguisorba Officinalis Root Extract as a treatment for hair loss by inhibiting FGF-5. The user also mentions the product évolis, which is based on this extract but is only available in the US and Australia.

      community Canadians, is CBSA seizing anageninc RU58841 powder?

       1 upvotes 1 month ago
      The conversation discusses the successful receipt of RU58841 powder in Canada, with no reported issues from a user in British Columbia. The original poster is curious about potential seizures by CBSA but hasn't purchased it yet.

      community Any updates on upcoming hair loss medication?

       17 upvotes 2 years ago
      The conversation discusses updates on hair loss treatments, specifically GT20029, PP405, and a rumored injectable peptide from UT. GT20029 is seen as a promising treatment expected within 5-7 years.

      community Castor oil

       6 upvotes 10 years ago
      The user experienced reduced hair shedding and less itching after using oral castor oil alongside finasteride and minoxidil. They suggest trying castor oil, though they acknowledge the improvements might be due to the other treatments.

      community Nordic biolabs Stem cells = Apple Stem Cells

       5 upvotes 2 years ago
      A new hair growth product claims to use apple stem cells, plant collagen, and bamboo leaf extract, with a 120-day money-back guarantee. Some users are skeptical, noting the product's marketing alongside other treatments like Minoxidil, finasteride, and red light therapy.

      community Plant-based Exosomes Efficacy Sourced from South Korea

       2 upvotes 1 year ago
      Plant-based exosomes for hair loss lack scientific evidence and are considered high-risk with low evidence. Combining PRF with minoxidil and finasteride is suggested as a better option.

      community MSM Supplementation is helping my hairs

       4 upvotes 6 months ago
      The user reports that MSM supplementation has thickened their hair strands while using finasteride and topical minoxidil. They also take zinc, copper, B-complex, vitamin C, vitamin D3, and K2, and plan to add omega-3, magnesium, astaxanthin, and pterostilbene.

      community Saw this apparent study on twitter. Thoughts?

       5 upvotes 2 years ago
      A mixture of MSM, kombucha, and black tea was applied topically for hair growth in mice. The conversation suggests skepticism about translating these results to humans.

      community Making my own topical finasteride - ethanol question

       4 upvotes 3 years ago
      The conversation is about making topical finasteride using ethanol. The user is advised to use non-denatured or food-grade ethanol, as denatured ethanol may be harmful with prolonged skin exposure.

      community Shedding and sides from pumpkin seed oil? This sounds ridiculous...

       2 upvotes 9 years ago
      Pumpkin seed oil may cause side effects similar to finasteride, such as brain fog, lethargy, and reduced libido, but it hasn't shown positive results for hair loss. Users suggest reducing the dosage or consulting a doctor, and other treatments like finasteride, minoxidil, and hair transplants are mentioned as alternatives.

      community From finasteride to Serenoa repens

       1 upvotes 9 months ago
      The user experienced anxiety and side effects from topical finasteride and is considering switching to saw palmetto. Another user reported no improvement with saw palmetto and experienced liver issues.

      community pumpkin seed oil?

       4 upvotes 9 years ago
      Pumpkin seed oil may help with hair loss by weakly inhibiting 5α-reductase, but its effects are marginal compared to finasteride. Saw Palmetto is another mild DHT inhibitor worth considering.

      community Broccoli supplement (Sulforaphane) for better Minox results?

       4 upvotes 3 years ago
      Broccoli or sulforaphane supplements are unlikely to improve Minoxidil results due to the need for an unrealistically large dose. Tretinoin, micro-needling, and low-dose oral Minoxidil may be more effective for those lacking the necessary enzyme in the scalp.

      community ABS-201 Trial - What should I know going in

      in Research/Science  28 upvotes 6 months ago
      The conversation is about a user preparing to join the ABS-201 clinical trial for hair loss treatment, which involves a prolactin inhibitor. The user plans to update others on their progress if enrolled.

      community Gray market sources to get gt20029 or pp405?

      in Product  2 upvotes 1 year ago
      The conversation is about sourcing gray market compounds, gt20029 and pp405, for hair loss treatment. The user is interested in these compounds despite their unproven status and potential risks.

      community Is there new research about pumpkin oil as a DHT blocker (2026)?

       11 upvotes 4 months ago
      Pumpkin seed oil is considered a weak DHT blocker compared to finasteride and dutasteride, with some users reporting side effects like mood changes and reduced libido. Despite some anecdotal benefits for urinary issues, it is not effective for hair loss, and finasteride is preferred by some users for its lack of side effects.

      community Won’t pp405 and gt20029 be patented and be almost unreasonably expensive

       29 upvotes 1 year ago
      Concerns about the potential high cost of new hair loss treatments, pp405 and gt20029, were discussed, with some users willing to pay a premium if they are effective. Alternatives like finasteride and minoxidil are mentioned as current, more affordable options, and there is speculation about future generic versions and black market availability.

      community How long are Pelage going to milk the phase 2a results of PP405?

       21 upvotes 7 months ago
      PP405, a potential hair loss treatment, is facing delays in releasing Phase 2 results, causing frustration among users who compare it to past failed treatments. Despite skepticism, some remain hopeful about PP405's future, while others discuss alternative treatments like Clascoterone and its expected market release.