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      community The theory that explains everything. Please help me make this big!

      in Research/Science  2447 upvotes 3 years ago
      The post and conversation are about the role of the enzyme 3alpha-hydroxysteroid reductase in hair loss and the potential of compounds like procyanidin B2 and sulforaphane to boost its activity for hair regrowth. Further research is needed to develop effective treatments based on this theory.

      community Minoxidil and facial aging

      in Minoxidil  53 upvotes 4 years ago
      Minoxidil may cause facial aging or wrinkles, though opinions vary. Some users report side effects like dark circles and facial bloating, while others attribute changes to genetics or other factors.

      community “Just shave it” is bullshit

       137 upvotes 5 years ago
      Accepting hair loss and not taking drastic measures like shaving your head if you are only mildly balding, and encouraging people to fight it with treatments such as finasteride, minoxidil, nizoral and microneedling. Additionally, it discusses the importance of being realistic when trying to restore hair and addressing the misconception that one must look a certain way in order to be attractive.

      community How are people getting DUT so easily?

      in Finasteride/Dutasteride  15 upvotes 2 months ago
      Dutasteride is hard to get in Europe due to prescription rules, leading some to consider online pharmacies or travel. Users discuss alternatives like private doctors and compare it to finasteride, expressing concerns about side effects and effectiveness.

      community 1ish year on fin and no improvement

      in Is this regrowth?  86 upvotes 2 months ago
      The user has been using finasteride for over a year without improvement and recently started oral minoxidil. Suggestions include trying dutasteride and continuing minoxidil for potential regrowth.

      community Hair looks extremely thin under sunlight!

      in Chat  26 upvotes 2 months ago
      A 22-year-old male experiencing diffuse thinning is using oral minoxidil and finasteride but notices his hair looks thin in sunlight. Suggestions include using hair products, considering topical minoxidil, addressing seborrheic dermatitis, and possibly trying dutasteride or a hair transplant.

      community Why is everyone not directly advised Dutasteride?

      in Finasteride/Dutasteride  168 upvotes 3 months ago
      Dutasteride is less commonly prescribed for hair loss because it is not FDA-approved for this purpose, unlike finasteride, which is more accessible and preferred due to fewer side effects. Dutasteride may be more effective in reducing DHT but has a longer half-life and potentially more significant side effects.

      community Are they going to Ban Finasteride in the EU ?

      in Finasteride/Dutasteride  68 upvotes 3 months ago
      There is concern about a potential ban on finasteride in the EU, but many believe it is unlikely unless serious side effects are found. Users rely on finasteride for hair loss and other health benefits, and a petition has been created to oppose any restrictions.

      community 18-year progress pics. Fin only.

      in Progress Pictures  419 upvotes 3 months ago
      The user has been using finasteride for 18 years to manage hair loss and is considering starting minoxidil and possibly a hair transplant. Despite some regrowth, they are exploring additional treatments like dutasteride and oral minoxidil due to continued hair thinning.

      community Well… I Did It. Estrogen Saved My Hairline

      in Transgender  729 upvotes 3 months ago
      OP transitioned and used Spironolactone, Estradiol Valerate, Minoxidil, and dermarolling, resulting in significant hair regrowth. They advise this method may not be suitable for cis men.

      community DHT is about to get smashed ….

      in Update  804 upvotes 4 months ago
      The conversation discusses hair loss treatments like topical finasteride with minoxidil, oral dutasteride, and essential oils. Oral treatments like dutasteride and finasteride are seen as more effective, though some prefer topicals to avoid side effects.
      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 4 months ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.