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GlossaryTransdermal Delivery (skin delivery)

method of administering drugs through the skin for absorption

Transdermal Delivery, also known as Transdermal Drug Delivery, is a method of administering medications through the skin. This system allows drugs to be absorbed directly into the bloodstream, providing a controlled release over time. Common examples include nicotine patches for smoking cessation and hormone replacement therapy patches. This method can improve patient compliance and reduce gastrointestinal side effects compared to oral medications.

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community Has Anyone Heard About Ethossomal Finasteride? 6x Finasteride Delivery in Hair Folicule?

in Finasteride/Dutasteride 36 upvotes 1 year ago

A user is considering switching from oral to topical finasteride to reduce systemic DHT impact and is exploring ethossomal finasteride for better skin penetration and potential hair regrowth. They found ethossomal finasteride in Brazil and are seeking opinions on its effectiveness compared to other topical delivery methods.

community Soundwaves & Electricity Grows Hair? | Peptide Delivery Model.

in Research/Science 2 upvotes 3 months ago

Iontophoresis and sonophoresis can enhance drug delivery into the scalp. Combining these methods may improve the effectiveness of topical treatments like dutasteride and certain peptides.

community Keratin microspheres - breakthrough

in Research/Science 13 upvotes 8 months ago

A gel of keratin microspheres promotes hair follicle growth, showing similar effectiveness to minoxidil in mice. The treatment activates hair growth pathways and reduces inflammation, with potential applications in drug delivery for hair-related disorders.

community Protac degradation of the androgen receptor in mice shows good efficacy and no systemic drug could be found

in Research/Science 47 upvotes 1 year ago

The efficacy of degrading the androgen receptor through dermal application in DP cells, a delivery system for topical drugs that involves dissolving microneedles, and rosemary oil as an alternative anti-androgen.

community Peptides that Stop Hair Loss? | In-depth Literature Review Video

in Research/Science 71 upvotes 4 months ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community PG causing irritation when applying RU

in Research/Science 1 year ago

The user is experiencing irritation from using PG with RU58841 and is seeking alternative solutions like K&B in the UK. They report redness, itchiness, and flaky skin from the current treatment.

community Study Shows That Oral Minoxidil Is Not Only Good At Improving Hair But Also Reducing Arterial Stiffness And Preventing Other Health Problems

in Minoxidil 22 upvotes 3 years ago

Oral minoxidil may improve hair growth, reduce arterial stiffness, and prevent other health issues. Some users believe it is an effective treatment despite concerns about its effects on skin and blood.

community Injecting stomach fat into the scalp could cure baldness in just six months

in Update 114 upvotes 6 years ago

A potential treatment for hair loss that involves injecting fat into the scalp; the role of testosterone and estrogen in thinning fat tissue under the skin; research on using lard to treat androgenic alopecia, as well as PRP + ACELL/amniotic stem cell treatments; and ongoing clinical trials by doctors involved in the study.

community What does “Minoxidil tincture 5% Purified Water” mean exactly?

in Minoxidil 3 upvotes 9 months ago

A user is asking about the effectiveness of "Minoxidil tincture 5% Purified Water" compared to other Minoxidil 5% products. They experienced itching and redness with other Minoxidil products and suspect they might be allergic.

community Options - Topical Dut to oral Fin?

in Finasteride/Dutasteride 2 upvotes 10 months ago

The user experienced headaches and brain fog with a topical solution containing Dutasteride, Minoxidil, Tretinoin, Fluocinolone, Latanoprost, and Caffeine. They are considering switching to oral or topical Finasteride to see if it alleviates these side effects.

community Lion Mane Part 2: Microneedling with Topicals, beneficial compounds, maybe?

in Microneedling 1 upvotes 6 months ago

The conversation discusses microneedling techniques and the use of Minoxidil, copper peptides, EGF, FGF, ceramides, and hydration serums to enhance hair growth. It explores optimizing scalp conditions and the potential benefits of various compounds in conjunction with microneedling.

community Expectations control for SCUBE3

in Research/Science 22 upvotes 8 months ago

SCUBE3, a protein linked to hair growth in moles, was discovered over 25 years ago and is being developed by Amplifica for potential hair loss treatment. Concerns exist about SCUBE3's association with cancer, as it is a protein that promotes cell growth, which could potentially trigger cancer development if used for hair growth therapy.

community Holy shit. Verteporfin may actually be the cure

in Research/Science 1011 upvotes 1 year ago

The post and conversation discuss Verteporfin's potential as a hair loss treatment. It's shown promise in regrowing hair after transplants and might be effective with microneedling.

community Verteporfin update - donor hair regeneration human trial

in Research/Science 23 upvotes 2 years ago

A human trial of verteporfin, a potential treatment for hair loss, with some users noting potential improvements in scarring and overall healing compared to control areas.

community Wanted to share my hairloss treatment. All in one solution. Did a trichotest and they made me this solution. In addition I use caffeine liquid and saw palmento. Been on this for 40days now, started sheding. (Been on minoxidil 5% for a year befor this). What do you guys think?

in Treatment 49 upvotes 2 years ago

A user shared their hair loss treatment which includes a custom solution with multiple ingredients, caffeine liquid, and saw palmetto, and mentioned shedding after 40 days of use. Some replies discuss the effectiveness and cost of the treatment, while others debate the usefulness of topical dutasteride.

community Results: Finasteride, minoxidil, 1.5mm derma roller. There are 2 to 2.5 months between the two images.. which means I did 7-11 times of dermarolling

in Update 205 upvotes 4 years ago

Results from taking finasteride, minoxidil, and dermarolling to treat hair loss; the user's age and potential side effects of taking finasteride.

community Why aren't more people talking about dermarolling?

in Treatment 16 upvotes 6 years ago

Dermarolling has potential for hair regrowth and is being used alongside minoxidil and a rosemary oil/castor oil mix. Users discuss its effectiveness and the need for more research.

community He used Dutasteride for 20 years. Interview

in Treatment 109 upvotes 1 week ago

Dutasteride has been used for 20 years with some hair thickness improvement but no dramatic regrowth. The user also experimented with minoxidil, tretinoin, and peptides like BPC 157 for potential benefits in hair density and quality.

community Does Nuking Scalp DHT Theoretically Make Minoxidil Gains Permanent?

in Minoxidil 35 upvotes 1 week ago

Minoxidil gains are not permanent without continued use, even with DHT suppression. Combining treatments like Dutasteride, Finasteride, and RU58841 may help maintain hair, but stopping Minoxidil typically results in hair loss.

community Red Light Therapy: Cheap Chinese LED caps are better than $3000 laser caps

in Research/Science 33 upvotes 4 weeks ago

Affordable 92-LED caps may be more effective for hair growth than expensive 270-laser caps due to higher power output and irradiance. The LED caps deliver more energy to the scalp, making them a cost-effective alternative for red light therapy.

community Dutasteride takes 1-3 months to work in the scalp. Not weeks. Be careful.

in Finasteride/Dutasteride 41 upvotes 3 months ago

Dutasteride takes 1-3 months to affect scalp DHT levels, not just a week. The prostate absorbs Dutasteride faster than the scalp due to different vascular networks and enzyme densities.

community 5 Months! 1mg fin everyday. 1ml min topical every night. 1.5mm Microneedling with darma pen every week.

in Progress Pictures 161 upvotes 3 months ago

A user shared progress pictures after 5 months of using 1mg finasteride daily, 1ml minoxidil topically every night, and 1.5mm microneedling weekly. Responses included skepticism and congratulations.

community [M31] 2+ years progress on Oral Dutasteride and Sublingual Minoxidil

in Progress Pictures 67 upvotes 5 months ago

A user shared their 2+ years progress on Oral Dutasteride and Sublingual Minoxidil for hair loss. Another user asked about the form of Minoxidil used sublingually.

community Minoxidil Finasteride heart problems

in Update 97 upvotes 6 months ago

A user experienced heart problems after taking 1mg finasteride and 2.5mg oral minoxidil and is considering quitting minoxidil. Others discussed their experiences with heart issues and minoxidil, with some suggesting topical minoxidil as a safer alternative.

community Is something finally happening here? What do you think?

in Is this regrowth? 11 upvotes 1 year ago

The conversation discusses hair regrowth using RU58841 and Minoxidil in the morning, and Minoxidil with needle massage in the evening. The user is inquiring if there are signs of hair regrowth by comparing photos from September 3 to recent ones.

community Application tip for topicals. 1ml TB Syringe & Opthalmic Cannula.

in Product 66 upvotes 1 year ago

The post and conversation discuss different methods of applying hair loss treatments directly to the scalp. The original poster suggests using a 1ml TB Syringe & Ophthalmic Cannula for precise application, while others share their own methods, including sprays, droppers, and simple syringes.

community Finally decided to buzz it off after struggling with hair loss for the last five years. Very freeing. What do y’all think?

in Shaved/buzzed 344 upvotes 1 year ago

A user who buzzed their hair off after five years of struggling with hair loss, and the replies discussing whether or not they should go completely bald, as well as advice on cutting it shorter and potential treatments such as finasteride and minoxidil.

community Starting Pyrilutamide BID. First dose was yesterday. Diffuse thinning. I will put my full regimen below.

in Research/Science 89 upvotes 2 years ago

A user's regimen to help with their diffuse thinning, which includes taking Pyrilutamide BID, 1mg finasteride daily, 2.5mg oral minoxidil daily, topical minoxidil since August 2021, LLLT every two days, topical fin, progesterone, melatonin, minoxidil (started one week ago), pumpkin seed oil and not dermarolling; other commenters suggested Nizoral for dandruff control and caution when using pre-mixed products with Pyrilutamide.

community 3 months - Fin&Min Topical Spray, Tretinoin, Derminator 1.25 every 5-6 days

in Progress Pictures 145 upvotes 2 years ago

The conversation discusses a hair loss treatment regimen that includes a topical spray with finasteride and minoxidil, tretinoin, and using a Derminator (microneedling device) at 1.25mm depth every 5-6 days. The user reports positive results after 90 days and plans to continue the treatment, with others commenting on the process and potential outcomes.

community Homemade Topical Finasteride Formula?

in Treatment 7 upvotes 2 years ago

User wants to make homemade topical finasteride to minimize side effects and asks about using glycerin, stirring time, storage, and alternative solvents. Another user's comment is unclear.