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GlossarySkin Barrier Function

protects against external threats and prevents water loss

The Skin Barrier Function, also known as the Epidermal Barrier Function, refers to the skin's ability to protect the body from external threats like pathogens, chemicals, and physical injuries, while also preventing excessive water loss. This function is primarily carried out by the outermost layer of the skin, the stratum corneum, which consists of tightly packed dead skin cells and lipids that form a protective barrier.

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community Comprehensive Microneedling Guide

throwoveraccount in Microneedling 294 upvotes 2 years ago

Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

community Peptides that Stop Hair Loss? | In-depth Literature Review Video

noeyys in Research/Science 72 upvotes 7 months ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community The theory that explains everything. Please help me make this big!

joaopassos4444 in Research/Science 2453 upvotes 3 years ago

The post and conversation are about the role of the enzyme 3alpha-hydroxysteroid reductase in hair loss and the potential of compounds like procyanidin B2 and sulforaphane to boost its activity for hair regrowth. Further research is needed to develop effective treatments based on this theory.

community Topical finasteride now the safest possible path?

Least-Debate729 in Finasteride/Dutasteride 84 upvotes 6 months ago

Topical finasteride is considered a safer option for hair regrowth with fewer systemic side effects compared to oral finasteride. Some users report similar efficacy and side effects between topical and oral treatments, while others prefer topical due to reduced systemic exposure.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

nkrata in Research 830 upvotes 6 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community A systematic bro-science review of DHT, 5AR, neurosteroids, sexual health and 5AR inhibitors

rhguven in Research/Science 37 upvotes 2 years ago

Hair loss treatments, specifically 5AR inhibitors, can impact neurosteroids and sexual health. The effects of topical fin/dut on tissue-specific DHT levels are unclear.

community Keratin microspheres - breakthrough

KieronR101 in Research/Science 13 upvotes 11 months ago

A gel of keratin microspheres promotes hair follicle growth, showing similar effectiveness to minoxidil in mice. The treatment activates hair growth pathways and reduces inflammation, with potential applications in drug delivery for hair-related disorders.

community Countering oral minoxidil side effects by taking collagen supplements?

throwaway010322 in Minoxidil 16 upvotes 8 months ago

Oral minoxidil may deplete collagen, potentially causing skin aging. Users discuss whether taking collagen supplements can counteract this effect.

community Lion Mane Part 2: Microneedling with Topicals, beneficial compounds, maybe?

L3onidas-Kelevra in Microneedling 1 upvotes 8 months ago

The conversation discusses microneedling techniques and the use of Minoxidil, copper peptides, EGF, FGF, ceramides, and hydration serums to enhance hair growth. It explores optimizing scalp conditions and the potential benefits of various compounds in conjunction with microneedling.

community The truth about Dutasteride (w/ sources)

degenwealth in Finasteride/Dutasteride 52 upvotes 2 years ago

The effectiveness of Dutasteride compared to Finasteride in treating hair loss, with evidence given such as studies and experiences, as well as discussion around whether one should switch from Finasteride to Dutasteride. There is also a discussion on post-Dutasteride syndrome.

community A meta analysis of 18 popular hair loss treatments. An 2022 guide on efficacy. From finasteride and minoxidil to caffeine shampoo, saw palmetto and biotin. 96 Scientific References included.

MENSCRIPT in Research/Science 101 upvotes 2 years ago

Most hair loss treatments are ineffective; only finasteride, dutasteride, and minoxidil show effectiveness.

community I started rapidly diffuse thinning at 22. I'm 42 now and have as much hair as I did at 16. AMA

karlallan in Treatment 443 upvotes 4 years ago

Hair loss treatments like finasteride, minoxidil, ketoconazole, PRP, and microneedling helped maintain hair for 20 years. Research and try evidence-based treatments for best results.

community How to BECOME a RESPONDER to Fin/Dut if you are not responding

DuckSeasonCamelSeasn in Finasteride/Dutasteride 306 upvotes 1 year ago

The conclusion of this conversation is that the user "DuckSeasonCamelSeasn" found that consuming grapefruit juice prior to taking finasteride or dutasteride helped them become a responder to the medications and regain hair growth. However, there are warnings about potential risks and interactions with other medications, so caution should be exercised.

community Everyone is ignoring that plasma finasteride levels are 100x lower with topical compared to oral.

obafootballinstinct in Research/Science 136 upvotes 6 months ago

Topical finasteride results in plasma levels 100 times lower than oral finasteride, potentially reducing systemic side effects. Users report similar efficacy with fewer side effects, suggesting a preference for topical application.

community People who tolerate dut better than fin?

chadthunderjock in Finasteride/Dutasteride 32 upvotes 4 months ago

Dutasteride may have fewer side effects than finasteride, with some users experiencing better hair maintenance. Experiences vary, with some preferring dutasteride for fewer side effects, while others see no significant hair improvement.

community Estradiol mesotherapy / idea feedback

Sad_Account8130 in Female 7 upvotes 2 months ago

The conversation discusses using estradiol mesotherapy to replicate hormone replacement therapy results while minimizing systemic exposure. It also covers the use of Spironolactone cream, which reportedly has no systemic side effects, and the potential risks of using bicalutamide and Spironolactone in men.

community Do hair follicles ever really "die"? Or does all your front, mid, and crown hair just become vellus?

EvidenceStatus in Chat 143 upvotes 5 months ago

Hair follicles don't truly die but become severely miniaturized. Treatments like finasteride, dutasteride, and minoxidil can help restore hair by providing nutrients and reducing harmful effects on hair roots.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

MagicBold in Research 823 upvotes 3 months ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Why is nobody studying the difference between donor and balding hair?

Hairlssuf in Chat 89 upvotes 8 months ago

The conversation discusses why the difference between donor and balding hair isn't studied more to find a cure for hair loss. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community People's ignorance on MPB is both frustrating and harmful to balding men and it's important to educate other balding men on Fin/Min/Dut (Discussion)

PracticalDocument948 in Finasteride/Dutasteride 158 upvotes 1 month ago

Many are unaware of effective male pattern baldness treatments like finasteride and minoxidil, often opting for ineffective remedies. Educating others on proven treatments and potential side effects is crucial.

community When you start balding you notice how unnatural this phenomenon is

Otherwise-Tough-1688 in Chat 534 upvotes 1 month ago

Hair loss is a common issue, with treatments like finasteride and minoxidil used but not as permanent cures. Frustration exists over societal perceptions and the lack of a definitive solution.

community Wtf have we been doing for the last 30 years

No-Internet-7023 in Treatment 548 upvotes 1 month ago

Hair loss treatments like finasteride, minoxidil, and dutasteride work but have side effects. A permanent cure is still not available due to the complexity of hair loss and limited investment.

community 2024 guide for male pattern baldness: 10 take home messages from Dr. Moreno-Arrones

TibetanBiscuit in Research/Science 245 upvotes 4 months ago

Effective treatments for male pattern baldness include finasteride, dutasteride, and oral minoxidil. Non-effective approaches include oils, shampoos, serums, laser therapies, massages, vitamins, and microneedling.

community Dutasteride High Libido. How come we don't talk about this?

noeyys in Finasteride/Dutasteride 205 upvotes 3 months ago

Dutasteride and finasteride can affect libido differently, with some experiencing increased libido and others decreased libido or erectile dysfunction. Dutasteride may increase testosterone levels but can also cause side effects like liver enzyme changes, while topical finasteride may have fewer sexual side effects.

community Discussion on Finasteride and life.

kennymi in Chat 166 upvotes 3 months ago

Finasteride can aid hair regrowth but may cause side effects like depression and sexual dysfunction. Users discuss experiences with finasteride, minoxidil, and RU58841, highlighting varied responses and the importance of informed treatment choices.

community Do you guys wait 24 hours before applying minoxidil after dermarolling [.5 mm]?

sscw in Microneedling 12 upvotes 1 year ago

The conversation discusses whether to wait 24 hours before applying minoxidil after using a .5 mm dermaroller for hair loss treatment. The specific treatments mentioned are microneedling, minoxidil, and dermarolling.

community Anyone tried Tretinoin? I’ve heard great things

MichaelT1991 in Treatment 21 upvotes 1 year ago

People discuss using Tretinoin for both skin anti-aging and improving hair loss treatments. They mention combining Tretinoin with Minoxidil to enhance its effectiveness for hair growth.

community Tretinoin, any good, what’s your experience

chochotrainlove in Research/Science 21 upvotes 8 months ago

The conversation discusses using tretinoin for hair loss and skincare. Users share experiences, noting tretinoin's effectiveness in combination with minoxidil for hair and its proven benefits for anti-aging skincare.

community Does seborrheic dermatitis block absorption of topicals?

SilverRule in Treatment 10 upvotes 1 year ago

User wonders if seborrheic dermatitis blocks absorption of topicals for hair loss. They use nizoral to improve the condition but it's not fully gone.

community What happened to topical dutasteride??

PaleontologistOk1494 in Finasteride/Dutasteride 28 upvotes 1 week ago

Topical dutasteride is considered for hair loss, but concerns about systemic absorption and side effects like reduced libido are common. Users have mixed results, with some preferring oral finasteride or dutasteride despite side effects, while others find topical treatments beneficial but challenging.