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GlossarySkin Barrier Function

protects against external threats and prevents water loss

The Skin Barrier Function, also known as the Epidermal Barrier Function, refers to the skin's ability to protect the body from external threats like pathogens, chemicals, and physical injuries, while also preventing excessive water loss. This function is primarily carried out by the outermost layer of the skin, the stratum corneum, which consists of tightly packed dead skin cells and lipids that form a protective barrier.

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community Peptides that Stop Hair Loss? | In-depth Literature Review Video

in Research/Science 68 upvotes 2 months ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community Comprehensive Microneedling Guide

in Microneedling 290 upvotes 2 years ago

Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 1 month ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Topical finasteride now the safest possible path?

in Finasteride/Dutasteride 50 upvotes 2 months ago

Topical finasteride is considered a safer option for hair regrowth with fewer systemic side effects compared to oral finasteride. Some users report similar efficacy and side effects between topical and oral treatments, while others prefer topical due to reduced systemic exposure.

community The theory that explains everything. Please help me make this big!

in Research/Science 2446 upvotes 3 years ago

The post and conversation are about the role of the enzyme 3alpha-hydroxysteroid reductase in hair loss and the potential of compounds like procyanidin B2 and sulforaphane to boost its activity for hair regrowth. Further research is needed to develop effective treatments based on this theory.

community Keratin microspheres - breakthrough

in Research/Science 13 upvotes 6 months ago

A gel of keratin microspheres promotes hair follicle growth, showing similar effectiveness to minoxidil in mice. The treatment activates hair growth pathways and reduces inflammation, with potential applications in drug delivery for hair-related disorders.

community A systematic bro-science review of DHT, 5AR, neurosteroids, sexual health and 5AR inhibitors

in Research/Science 37 upvotes 2 years ago

Hair loss treatments, specifically 5AR inhibitors, can impact neurosteroids and sexual health. The effects of topical fin/dut on tissue-specific DHT levels are unclear.

community Countering oral minoxidil side effects by taking collagen supplements?

in Minoxidil 16 upvotes 3 months ago

Oral minoxidil may deplete collagen, potentially causing skin aging. Users discuss whether taking collagen supplements can counteract this effect.

community Lion Mane Part 2: Microneedling with Topicals, beneficial compounds, maybe?

in Microneedling 1 upvotes 4 months ago

The conversation discusses microneedling techniques and the use of Minoxidil, copper peptides, EGF, FGF, ceramides, and hydration serums to enhance hair growth. It explores optimizing scalp conditions and the potential benefits of various compounds in conjunction with microneedling.

community A meta analysis of 18 popular hair loss treatments. An 2022 guide on efficacy. From finasteride and minoxidil to caffeine shampoo, saw palmetto and biotin. 96 Scientific References included.

in Research/Science 103 upvotes 2 years ago

Most hair loss treatments are ineffective; only finasteride, dutasteride, and minoxidil show effectiveness.

community The truth about Dutasteride (w/ sources)

in Finasteride/Dutasteride 52 upvotes 1 year ago

The effectiveness of Dutasteride compared to Finasteride in treating hair loss, with evidence given such as studies and experiences, as well as discussion around whether one should switch from Finasteride to Dutasteride. There is also a discussion on post-Dutasteride syndrome.

community I started rapidly diffuse thinning at 22. I'm 42 now and have as much hair as I did at 16. AMA

in Treatment 451 upvotes 4 years ago

Hair loss treatments like finasteride, minoxidil, ketoconazole, PRP, and microneedling helped maintain hair for 20 years. Research and try evidence-based treatments for best results.

community Do hair follicles ever really "die"? Or does all your front, mid, and crown hair just become vellus?

in Chat 137 upvotes 1 month ago

Hair follicles don't truly die but become severely miniaturized. Treatments like finasteride, dutasteride, and minoxidil can help restore hair by providing nutrients and reducing harmful effects on hair roots.

community Everyone is ignoring that plasma finasteride levels are 100x lower with topical compared to oral.

in Research/Science 114 upvotes 2 months ago

Topical finasteride results in plasma levels 100 times lower than oral finasteride, potentially reducing systemic side effects. Users report similar efficacy with fewer side effects, suggesting a preference for topical application.

community Why is nobody studying the difference between donor and balding hair?

in Chat 89 upvotes 3 months ago

The conversation discusses why the difference between donor and balding hair isn't studied more to find a cure for hair loss. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community Anyone tried Tretinoin? I’ve heard great things

in Treatment 21 upvotes 7 months ago

People discuss using Tretinoin for both skin anti-aging and improving hair loss treatments. They mention combining Tretinoin with Minoxidil to enhance its effectiveness for hair growth.

community Does seborrheic dermatitis block absorption of topicals?

in Treatment 10 upvotes 1 year ago

User wonders if seborrheic dermatitis blocks absorption of topicals for hair loss. They use nizoral to improve the condition but it's not fully gone.

community i got more results 1 month 5 mg oral minoxidil and 1 mg dutasteride then i did 6 months on finasteride and topical minoxidil

in Finasteride/Dutasteride 49 upvotes 6 months ago

A user reported better hair regrowth with 5 mg oral minoxidil and 1 mg dutasteride than with finasteride and topical minoxidil, calling topical minoxidil a scam. Replies varied, with some defending topical minoxidil, questioning the user's application method, and suggesting that previous treatments might be contributing to the observed results.

community Procyanidin B2 Topical Serum - The Cheap, Complete(ish) DIY Formula

in Research/Science 6 upvotes 1 year ago

The conversation is about a homemade hair loss treatment serum containing Procyanidin B2, Aloe Vera Gel, Coconut Oil, Castor Oil, and Rosemary Essential Oil. The main concern is finding an affordable source of Procyanidin B2 and ensuring its stability in the serum at room temperature.

community Tretinoin, any good, what’s your experience

in Research/Science 20 upvotes 3 months ago

The conversation discusses using tretinoin for hair loss and skincare. Users share experiences, noting tretinoin's effectiveness in combination with minoxidil for hair and its proven benefits for anti-aging skincare.

community How long have you tried topical melatonin?

in Treatment 4 upvotes 6 months ago

The conversation is about the effectiveness of topical melatonin for hair loss, asking for details on dosage, frequency, duration of use, results, and brand information. An update includes a skeptical view on the studies regarding melatonin's effectiveness.

community Derm made me a topical finasteride solution but I'm sceptical

in Finasteride/Dutasteride 2 upvotes 9 months ago

A dermatologist prescribed a topical hair loss treatment containing finasteride, biotin, melatonin, and caffeine without alcohol. The user is skeptical about its effectiveness.

community Do you guys wait 24 hours before applying minoxidil after dermarolling [.5 mm]?

in Microneedling 12 upvotes 1 year ago

The conversation discusses whether to wait 24 hours before applying minoxidil after using a .5 mm dermaroller for hair loss treatment. The specific treatments mentioned are microneedling, minoxidil, and dermarolling.

community New Study and Product: Tomorrowlabs HSF

in Research/Science 7 upvotes 1 year ago

New product Tomorrowlabs HSF targets hair loss through HIF pathway indirectly by removing scalp iron. Minoxidil and Stemoxydine also relate to HIF pathway.

community 6 week update fellas, 5mg oral minoxidil. Pics are 2nd June – 10th July

in Progress Pictures 2 years ago

, you can find it online with a script This user was discussing their progress with hair loss treatments including 5mg oral Minoxidil and combining 3mg oral Minoxidil with MTF HRT. They also discussed side effects of increased body hair in other parts of the body.

community Topical T3 study - 1000% Growth. Anyone tried it?

in Research/Science 106 upvotes 3 years ago

The conversation discusses using T3 (triiodothyronine) as a topical treatment for hair growth, with some users noting it showed promising results in studies but lacked follow-up. Users express interest in trying T3 due to its potential effectiveness compared to Minoxidil.

community Topical Dutasteride is Here.

in Finasteride/Dutasteride 153 upvotes 3 years ago

The availability of Topical Dutasteride, a potential treatment for hair loss, which can be purchased without prescription from MinoxidilMax. Other treatments discussed include Topical Finasteride and PRP injections, with discussion around dosage, efficacy, side-effects and safety.

community 2 months topical dutasteride plus minoxidil, very happy with the results!

in Finasteride/Dutasteride 337 upvotes 3 years ago

A user's success in treating their hair loss with 2x daily topical dutasteride and minoxidil, as well as the potential for using less frequent application of topical dutasteride due to its long half-life.

community Why nobody uses 0.25% (2.5mg/ml)?

in Treatment 64 upvotes 8 months ago

The conversation is about the effectiveness of 0.25% topical finasteride compared to other concentrations and forms. Users discuss its potential for better scalp DHT reduction and fewer side effects, with some preferring topical over oral treatments.

community M21 I stopped finesterid 3 Months ago... this is how it looks now

in Finasteride/Dutasteride 176 upvotes 3 months ago

A user stopped finasteride due to side effects and rapid hair loss, considering a hair system. Others suggested alternatives like dutasteride, minoxidil, and topical finasteride.