The user has been using liposomal topical finasteride since late 2022, progressively increasing the dose, but DHTserumlevels remain largely unchanged. Despite using finasteride, minoxidil, microneedling, and ketoconazole, hair condition has neither improved nor worsened.
The effects of smoking cigarettes on DHTlevels and its potential effect on hair loss, with some people sharing experiences in relation to their own hair loss. Various treatments for reducing or reversing hair loss were discussed, such as quitting smoking, minoxidil, finasteride and RU58841.
The user is starting dutasteride mesotherapy and seeks information on checking serumDHTlevels in Germany. They previously tried finasteride but experienced unpleasant side effects.
The conversation discusses the fluctuation of testosterone levels in men under 40 and the difference between serumDHT and scalp DHT. It also mentions that DHTlevels are higher on Dutasteride than on Finasteride, which is unusual.
Hair loss treatments, specifically, discussing the effectiveness and side effects of finasteride, minoxidil, and RU58841 in various microdoses. It also includes an updated graph which provides information on how different doses affect DHTlevels, scalp skin and serum androgen levels, as well as hair count.
SerumDHT is mostly inactive; sebum DHT is a better measure for hair loss. Users discuss using finasteride, dutasteride, and topical treatments like KX826 and RU58841 for better scalp DHT suppression.
A user experienced increased hair shedding and unchanged DHTlevels after taking 0.25mg of finasteride for 47 days, leading them to increase the dose to 0.5mg. Others discussed varying experiences with finasteride, minoxidil, and the importance of measuring scalp DHT.
A user increased their dutasteride dosage from 0.5mg to 1mg daily, resulting in a rise in DHTlevels from 148 pg/mL to 281 pg/mL, and is considering switching back to finasteride due to continued hair loss. Replies suggest retesting and emphasize the importance of bloodwork before starting treatments.
The impact of creatine on DHTlevels, and whether it could cause accelerated male pattern baldness (MPB). The user taking a 5 alpha reductase inhibitor found that their DHTlevels actually reduced despite taking creatine for nine weeks. Replies suggested looking into testosterone levels as well and debating the safety of creatine use in relation to MPB.
The user reported early stage diffuse hair thinning and increased DHTlevels after 4 weeks on Finasteride and 8 weeks on Finasteride plus 4 weeks on Dutasteride, despite the medications being authentic and stored properly. They are considering increasing their Dutasteride dosage due to the lack of side effects and are unsure if the treatment is helping their hair.
A user's experience with using 5AR inhibitors (Finasteride and Dutasteride) in combination with Minoxidil foam and microneedling, which resulted in substantial improvements to their crown density and hairline, despite high systemic levels of testosterone and dihydrotestosterone.
Dutasteride mesotherapy showed increased hair density and diameter without reducing serumDHTlevels in a small study. However, the sample size was too small to make definitive claims about its efficacy.
Researching and developing an effective local antagonist to block the androgen receptors for hair loss, as opposed to using DHT synthesis inhibitors that lower serumDHTlevels. Several treatments such as CosmeRNA and Pyrilutamide are currently in development or undergoing trials.
Creatine may increase scalp DHT without affecting serumDHT, potentially speeding up male pattern baldness (MPB) for those genetically prone. Treatments mentioned include Minoxidil, finasteride, and RU58841.
A 27-year-old man shared his hormonal panel results after one year of taking finasteride 1mg/day for hair loss, showing his DHTlevels nearly doubled. He reported stabilized hair loss with mild side effects that resolved, and he is considering a hair transplant but is concerned about the increased DHTlevels and potential treatment options.
The user discussed switching from RU58841 with Minoxidil to Finasteride due to cost, noting better physical feelings and hair growth with RU58841. They are considering returning to RU58841 and checking DHTlevels after a month.
The conversation discusses the effectiveness of different concentrations and dosages of topical finasteride on scalp and serumDHTlevels, comparing it to oral finasteride and noting the side effects seem to be fewer at lower dosages. Participants shared experiences and referenced a chart indicating similar scalp DHT reduction with 0.025% topical finasteride as with 1mg oral finasteride, but with fewer side effects.
The user had high DHTlevels after 8 months on dutasteride, questioning the drug's authenticity. They got dutasteride from a legitimate source and will update on progress.
Creatine may increase DHTlevels, potentially causing symptoms like acne, oily hair, and hair shedding. Users report mixed experiences, with some avoiding creatine due to hair loss concerns and others seeing no impact.
The conversation discusses the effects of lowering DHT on hair loss and the importance of monitoring DHTlevels during treatment. The user suggests that individual responses to DHT and hair loss treatments vary, and expresses a preference for topical treatments over oral medications due to concerns about systemic DHT reduction.
A user experienced no reduction in DHTlevels after 8 months of finasteride, despite initial improvement in hair loss. They are considering switching to dutasteride but are concerned about potential side effects.
A user shared their experience using topical finasteride for 6 months, showing a reduction in DHTlevels but no visible improvement in hair loss. They are considering switching to oral finasteride for potentially better results.
Despite using 5% minoxidil, 0.1% finasteride, and other treatments like microneedling, MK-677, and Cialis, hair loss continues with high testosterone and DHTlevels. Considering oral dutasteride but concerned about further increasing testosterone levels.
Hair loss treatments, specifically 5AR inhibitors, can impact neurosteroids and sexual health. The effects of topical fin/dut on tissue-specific DHTlevels are unclear.
A 21-year-old male suffering from male pattern baldness is using topical finasteride and minoxidil, and oral minoxidil. His bloodwork shows normal DHTlevels and slightly high testosterone, leading to discussions about the role of DHT sensitivity in hair loss, the potential impact of finasteride on his DHTlevels, and the suggestion to proceed with oral finasteride due to his high testosterone.
Topical finasteride as a potential alternative to oral finasteride for reducing DHTlevels on the scalp with fewer side effects, and other hair loss treatments such as minoxidil.
Dutasteride takes 1-3 months to affect scalp DHTlevels, not just a week. The prostate absorbs Dutasteride faster than the scalp due to different vascular networks and enzyme densities.
The conversation discusses using very low dose topical finasteride to achieve specific serumDHT reduction percentages. It concludes that finasteride dosage increases linearly between 5-30% DHT reduction but requires exponential increases for reductions up to 70%.
A user shared their experience with Finasteride for hair loss, noting a significant reduction in DHTlevels and a complete loss of libido without other side effects. Another user agreed, discussing the negative impact on sexual drive and criticizing the community's attitude towards discussing side effects.