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      community PP405 Update and My Take on Pelage

      in Research/Science  86 upvotes 10 months ago
      Pelage Pharmaceuticals raised $120M for their hair loss treatment, PP405, showing strong investor confidence despite limited data. There is skepticism about its efficacy and long-term effects compared to treatments like GT20029.

      community progress pics (HRT, fin, min, microneedling) (35, trans non-binary)

       11 upvotes 1 year ago
      A non-binary transfeminine person experienced significant hair regrowth after starting finasteride, minoxidil, microneedling, and hormone replacement therapy with estradiol. They encourage trans individuals concerned about hair loss to consider estrogen as it has greatly improved their hair condition.

      community How to make a RU58841 solution (50mL 5% strength)

       33 upvotes 2 years ago
      The conversation discusses making a RU58841 solution for hair loss prevention and includes personal experiences with using RU58841 and minoxidil for hair regrowth, with a mention of monitoring health effects.

      community Great news recently for people with hairloss!

      in Research/Science  113 upvotes 1 year ago
      A potential treatment for alopecia involving a protein that calms hair follicles has shown promise in rats, but skepticism remains about its applicability to humans. Many users express doubt about the timeline for effective hair loss treatments, comparing it to past unfulfilled promises.

      community Testing recommendations from lack of min/fin success

       1 upvotes 8 months ago
      The user has been using minoxidil, finasteride, a laser cap, and ketoconazole shampoo for hair loss without success and is seeking advice on further tests or treatments. They have a family history of hair loss and have not yet undergone dermatologist or trichology tests.

      community New Hair Loss Cure: AMP-303 Is Back. It’s what PP405 should have been.

       7 upvotes 5 months ago
      AMP-303 and AMP-601 are new hair loss treatments targeting dermal papilla cells, with AMP-303 showing early efficacy in transitioning vellus hairs to terminal hairs after one injection. Further clinical trials are planned, and these treatments are seen as promising due to their biologic approach and less frequent application compared to daily treatments.

      community What's going on with hmi115? The Phase 2 was concluded Nov2024 but no news

       13 upvotes 9 months ago
      Hmi115, a prolactin receptor blocker, showed promise for hair growth, but results from Phase 2 trials have not been published. ABS-201, an AI-based analog, is expected to begin trials in December 2025, while commercialization of treatments like PP-405 is anticipated around 2027.

      community Micronutrient testing, deficiencies, etc.

       4 upvotes 4 years ago
      Micronutrient testing and deficiencies related to hair loss, particularly androgenetic alopecia (AGA). Discussion includes the impact of iron, selenium, zinc, copper, folate, B12, vitamin E, vitamin D, amino acids, and fatty acids, alongside treatments like dutasteride or finasteride.

      community Why are there no proper phase 3 trials for RU

      in Chat  4 upvotes 6 months ago
      RU58841 lacks FDA approval due to financial and safety concerns, including potential cardiological side effects. The company abandoned further research, and users report adverse effects like heart palpitations and gynecomastia.

      community Bare Anatomy - Advanced Hair Growth Serum

      7 months ago
      A user is considering using Bare Anatomy's Advanced Hair Growth Serum, which contains Redensyl, Anagin, Baicapil, Rosemary, and Biotin, for thinning hair. Reviews are mixed, with some users skeptical about its effectiveness compared to minoxidil.

      community Any chemists want to manufacture PP405 / JXL069? (Steps inside)

       114 upvotes 1 year ago
      The conversation discusses the potential of PP405 as a hair loss treatment, with some users expressing skepticism and others hopeful about its development. There is also mention of other treatments like Minoxidil, Finasteride, and Pyrilutamide, with users debating the effectiveness and safety of self-experimentation versus waiting for clinical trial results.

      community What do you think of these hair transplants?

       308 upvotes 9 months ago
      Hair transplants in Bangkok are praised for their natural appearance, with a zigzag hairline design being favored over straight lines. The clinic Hairtran and Dr. Patty receive positive feedback, though some users express skepticism about photo filters and the authenticity of results.

      community Peter h diamandis Dr David Sinclair podcast

      6 months ago
      Hair loss treatments discussed include Minoxidil, finasteride, and RU58841. There is skepticism about claims of a breakthrough, despite FDA approval for human trials.

      community Ru58841 20mg….making my own solution

      in Treatment  1 upvotes 1 year ago
      The conversation is about making a 20mg/ml RU58841 solution for hair loss treatment using ethanol and propylene glycol. The user receives advice on calculating the correct amount of RU58841 powder needed.

      community Any active Kx-826 Pyrilutamide group buys happening?

       10 upvotes 4 years ago
      The conversation discusses organizing group buys and tracking progress for Kx-826 Pyrilutamide, a hair loss treatment. Participants express optimism about upcoming results and concerns about self-reporting bias.

      community RU58841 Permanently Fixed Balding In Unexpected Way.

      in Satire  123 upvotes 10 months ago
      The user humorously describes trying various hair loss treatments, including minoxidil, finasteride, and RU58841, with a satirical twist involving psychedelic experiences and imaginary entities. They mistakenly used LSD instead of RU58841 and plan to continue experimenting with other substances.

      community Best brand of hair fibres to buy?

       6 upvotes 5 days ago
      A user in the UK is seeking recommendations for hair fibers. Nanogen is suggested as a good brand.

      community The perfect reverse reverse hair-loss nuclear stack for those who feel left out

      in Satire  415 upvotes 1 year ago
      A satirical discussion on intentionally inducing hair loss using harmful habits and substances like cigarettes, junk food, anabolic steroids, and stress. The conversation humorously suggests extreme measures like chemotherapy and hydrofluoric acid, while also mentioning the ineffectiveness of sulfates and pumpkin seed oil in hair loss prevention.

      community Microneedling vs injections - recommendations needed

       2 upvotes 1 year ago
      The conversation discusses treatments for a receding hairline, specifically comparing microneedling with exosomes to injecting them. The user seeks recommendations for beginner-friendly resources, such as YouTube videos, to help start these treatments.

      community About Pyrilutamide Phase II US Trial

      in Research/Science  11 upvotes 3 years ago
      The conversation discusses the comparison of Pyrilutamide Phase II US trial results with 1 mg finasteride for hair loss treatment. It mentions that the total hair count increase in the US trial was not as good as the China trial.

      community Using a 2-deoxy-d-ribose gel. My experience 2 weeks in.

      in Treatment  38 upvotes 1 year ago
      The user switched from minoxidil to a homemade 2-deoxy-d-ribose gel and noticed no hair fall after two weeks, despite stopping minoxidil. The gel includes water, 2-deoxy-d-ribose, vegetable glycerine, 2-phenoxyethanol, sodium alginate, and rosemary oil, and the user reports healthier-feeling hair.