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    Did you mean 5α-reduction?
    Glossary5α-reductase activity (5α-reduction)

    enzyme converts testosterone into potent androgen dihydrotestosterone (DHT)

    5α-reductase activity refers to the function of the enzyme 5α-reductase, which converts testosterone into dihydrotestosterone (DHT), a more potent androgen. This process is significant in various biological functions, including the development of male characteristics and the regulation of hair growth. Elevated 5α-reductase activity is often associated with conditions like androgenetic alopecia (male pattern baldness) and benign prostatic hyperplasia.

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      community Nizoral ketaconazole any good for dht reduction

      in Ketoconazole  9 upvotes 3 years ago
      A 17-year-old is looking for alternatives to finasteride for DHT control to preserve hair, considering ketoconazole shampoo for its potential to inhibit 5AR and also thinking about using caffeine-containing shampoos like alpecin or watermans.

      community Is this broscience? From More Plates, More Dates

      in Research/Science  22 upvotes 8 months ago
      The conversation discusses whether finasteride's reduction of DHT and increase in scalp testosterone contribute to hair follicle miniaturization. Some participants argue testosterone does not cause miniaturization, while others suggest that even with reduced DHT, other androgens like testosterone may still contribute to hair loss.

      community My experience with Pyrilutamide:

      in Research/Science  7 upvotes 1 year ago
      The user started using pyrilutamide for hair loss and experienced a significant reduction in hair shedding and an improvement in hair quality with only mild side effects. They previously used minoxidil and finasteride, which caused side effects, and are now combining pyrilutamide with minoxidil and tretinoin.

      community my Body hair has stopped working

      in Finasteride/Dutasteride  44 upvotes 8 months ago
      A user on dutasteride for hair loss noticed hair regrowth on their head but a significant reduction in body hair growth. They plan to switch to finasteride and dutasteride and are considering testosterone replacement therapy but are concerned about its effects on hair growth.

      community Topical Finasteride strength discussion

      in Research/Science  66 upvotes 9 months ago
      The conversation discusses the effectiveness of different concentrations and dosages of topical finasteride on scalp and serum DHT levels, comparing it to oral finasteride and noting the side effects seem to be fewer at lower dosages. Participants shared experiences and referenced a chart indicating similar scalp DHT reduction with 0.025% topical finasteride as with 1mg oral finasteride, but with fewer side effects.

      community My Experience With Finasteride

      in Research/Science  20 upvotes 1 year ago
      A user shared their experience with Finasteride for hair loss, noting a significant reduction in DHT levels and a complete loss of libido without other side effects. Another user agreed, discussing the negative impact on sexual drive and criticizing the community's attitude towards discussing side effects.

      community Tretinoin every other day? (with daily minoxidil)

      in Minoxidil  1 upvotes 2 weeks ago
      The user is considering using Tretinoin every other day alongside daily Minoxidil to manage hair loss and is concerned about inconsistent absorption affecting regrowth. They have noticed a significant reduction in shedding but are unsure if it's due to Tretinoin or the end of the Minoxidil/finasteride shedding phase.

      community Hairloss Treatment - General health and efficacy-conscious stack overview

      in Treatment 3 weeks ago
      The conversation discusses managing hair loss and seborrheic dermatitis with treatments like minoxidil, finasteride, and saw palmetto, emphasizing the importance of scalp health and DHT reduction. The user shares personal experiences and suggests a balanced approach, combining topical treatments and lifestyle changes for effective hair regrowth.

      community M28, Surprising 20 day progress

      in Progress Pictures  6 upvotes 5 months ago
      A 28-year-old shared surprising hair regrowth progress after 20 days using topical minoxidil, micro needling, GHK-cu, and BPC-157 injections. The user noted a significant reduction in their bald spot and overall hair improvement.

      community Topical fin+minox deadly combo. M30 gave up and came back from dead.

      in Progress Pictures  14 upvotes 6 months ago
      A user reported hair regrowth using a homemade topical solution of minoxidil and finasteride sourced from Pakistan, combined with microneedling, after experiencing hair loss with UK-based products. They claim a reduction in hair loss from 200-300 to 3-5 hairs a day and advise against spending money on branded products.

      community Lowering DHT vs measured level and topical scalp treatment issues

      in Research/Science  1 upvotes 7 months ago
      The conversation discusses the effects of lowering DHT on hair loss and the importance of monitoring DHT levels during treatment. The user suggests that individual responses to DHT and hair loss treatments vary, and expresses a preference for topical treatments over oral medications due to concerns about systemic DHT reduction.

      community 2.5mg dut safety/price/synergy w/topical fin

      in Finasteride/Dutasteride  3 upvotes 8 months ago
      The conversation discusses the safety and cost of 2.5mg Dutasteride, and the potential for increased DHT reduction by combining Dutasteride with topical Finasteride. The original poster is currently using 0.5mg Dutasteride, 1.25mg oral Minoxidil, and a topical treatment, and is considering increasing the dosage to maximize results while avoiding less known treatments like RU58841.

      community Finasteride increase in Estradiol?

      in Update  17 upvotes 8 months ago
      A user experienced increased estradiol, nipple tenderness, and ED after taking finasteride. They are considering dose reduction to mitigate these effects.

      community Why nobody uses 0.25% (2.5mg/ml)?

      in Treatment  65 upvotes 9 months ago
      The conversation is about the effectiveness of 0.25% topical finasteride compared to other concentrations and forms. Users discuss its potential for better scalp DHT reduction and fewer side effects, with some preferring topical over oral treatments.

      community 8 week - sharing Finasteride blood test update

      in Progress Pictures  6 upvotes 10 months ago
      A 32-year-old male started taking 0.5mg of finasteride daily for hair thinning and, after 8 weeks, experienced a 70% reduction in DHT and an increase in estradiol; he is currently in the shedding phase of treatment and questioning if the dosage is correct based on his DHT levels. He began with a lower dose due to already low normal testosterone and DHT levels.