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GlossaryPromoter Region (promoter site)

specific DNA sequence where RNA polymerase binds to initiate transcription

The promoter region is a specific sequence of DNA located near the start of a gene that acts as a binding site for RNA polymerase and other transcription factors. This region essentially "promotes" the initiation of transcription, the process by which the genetic code from DNA is copied into messenger RNA (mRNA). Understanding promoter regions is crucial in fields like genetics and molecular biology, as they play a key role in regulating gene expression.

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community New Study and Product: Tomorrowlabs HSF

alekkrs in Research/Science 8 upvotes 1 year ago

New product Tomorrowlabs HSF targets hair loss through HIF pathway indirectly by removing scalp iron. Minoxidil and Stemoxydine also relate to HIF pathway.

community UPDATE: The theory that explains everything. Please help me make this big!

joaopassos4444 in Research/Science 448 upvotes 3 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

community The Real Cause Of Androgenetic Alopecia

AccutaneEffectsInfo in Research/Science 673 upvotes 3 months ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community Why don't the Nizoral manufacturers promote their product for MPB?

waffenwolf in Ketoconazole 12 upvotes 2 years ago

Ketoconazole is somewhat effective for male pattern baldness (MPB), but the manufacturer promotes it for dandruff instead, possibly because the dandruff market is larger and to avoid confusion among dandruff sufferers without hair loss.

community Light therapy helps hair growth (Studies included)

ChrisTeaching in Research/Science 23 upvotes 9 months ago

Red light therapy is scientifically proven to promote hair growth by increasing strand density and thickness, and it's an additional treatment to DHT blockers like minoxidil and finasteride. Some users are skeptical about the cost and effectiveness of commercial devices, despite studies showing benefits.

community Sulforaphane Topical to Degrade DHT - For People Who Want to Try the Theory that Explains Everything

sonictemples in Treatment 38 upvotes 3 years ago

A user suggests making a potent sulforaphane topical to degrade DHT and promote hair growth. Another user notes that sulforaphane's low molecular weight might also lower systemic DHT.

community August 2022 vs March 2023. Hair progress on crown and temples.

auxerrej in Progress Pictures 1 year ago

Hair loss treatments, specifically the use of Minoxidil, Finasteride, and RU58841 to promote hair growth in areas such as the crown and temples. The user has shared their progress since August 2022 after using Manual's all-in-one capsule treatment plan.

community Verteporfin day 119 update - donor hair regeneration human trial

Synizs in Research/Science 146 upvotes 2 years ago

A human trial of verteporfin, a drug that can inhibit wound healing by scarring and promote regeneration of original tissue and hair follicles to provide an unlimited source for hair transplants; people discussed the potential of this drug and how it could be rolled out in mainstream with more doctors getting on board.

community A rant about hair loss misinformation on social media

Cyrustd in Chat 48 upvotes 1 year ago

Social media spreads misinformation about hair loss, often promoting unproven treatments like diet changes. Effective treatments like Minoxidil, finasteride, and RU58841 are overlooked.

community [Discussion] Interesting read on Vitamin E for hair loss I found

throwawayaking in Advice 16 upvotes 6 years ago

The conversation discusses using Vitamin E, Minoxidil, finasteride, and RU58841 for hair loss treatment. The link provided offers more information on the benefits of Vitamin E for hair loss.

community What Works to Restore Hairloss for Cis-Males? Not Much

JaneyElizabeth in Treatment 20 upvotes 4 years ago

Hair regrowth treatments for cis-males include Minoxidil, Finasteride, and RU58841. Estrogen and testosterone blockers can help restore hair loss but may not suit everyone.

community Scalp tension and thickness of the galea aponeurotica, inflammation and potential treatment pathways

cadoloso in Research/Science 2 years ago

Scalp tension potentially affecting hair loss, and potential treatments for male pattern baldness such as Minoxidil, Finasteride and RU58841. Evidence from a study was discussed which suggests that the cause of MPB lies within the follicle itself and is not dependent on its surrounding environment.

community Started June 8th, 3 month update

Typ0sz in Progress Pictures 127 upvotes 1 year ago

A user started using Happyhead Dut and Minoxidil topical for hair loss, skipping finasteride. They've seen progress in three months, with slight shedding initially, and have not used finasteride before.

community Anyone still waiting on Pryiltamide order

Tall-Stick in Chat 2 upvotes 5 months ago

The user is frustrated with the delayed delivery of their Pryiltamide order from Koshine. They mention the order was shipped on August 23 but have received no updates since.

community Tried to take progress pictures for you guys. Some of the photos in the beginning were before i started treatment. Been on fin 1mg and (minoxidil 5% twice a day )for 3 months.

Shama2 in Progress Pictures 930 upvotes 1 year ago

The conclusion of the conversation is that the combination of finasteride and minoxidil has helped the user, Shama2, achieve fast and good results in regrowing hair. They have not experienced any side effects and are consistent with their treatment.

community 18M progression pt.3 (6 months)

Lolloquarry in Progress Pictures 744 upvotes 1 year ago

User started balding at 16 and began treatment at 18, using RU58841, minoxidil, derma rolling, and peptides. After 6 months, they experienced significant hair regrowth and are happy with the results.

community Hair Remedies that Don't Work for Anybody Seeking Hair Regrowth

JaneyElizabeth in Treatment 7 upvotes 4 years ago

Hair loss treatments discussed include minoxidil, finasteride, and RU58841. Salon products and supplements generally don't work for hair regrowth unless there's a severe nutritional deficiency, while hormonal treatments like estrogen and spironolactone can be effective.

community Tressless When They See Verteporfin Results

Synizs in Transplants 182 upvotes 1 year ago

The conversation discusses the potential of Verteporfin, an FDA-approved drug, for hair loss treatment, particularly in combination with microneedling or PRP. Users express hope and curiosity about its application, while some remain cautious due to the need for more extensive testing.

community Interesting article links major MPB theories to western diet (and life-style)

patrickular in Research/Science 58 upvotes 2 months ago

Poor diet and lifestyle contribute to male pattern baldness. Treatments like Minoxidil, dietary changes, and lifestyle adjustments may help slow hair loss.

community Why Cant we just find an effective androgen receptor antagonist that works locally on the scalp?

groyosnolo in Research/Science 1 year ago

Researching and developing an effective local antagonist to block the androgen receptors for hair loss, as opposed to using DHT synthesis inhibitors that lower serum DHT levels. Several treatments such as CosmeRNA and Pyrilutamide are currently in development or undergoing trials.

community 7-month (fin/min/keto/micro) Progress [34M]

SavetheFollys in Progress Pictures 543 upvotes 1 year ago

User shared 7-month progress of hair loss treatment, using daily 1mg Fin, 2x Min, monthly micro-needling, and ketocoz shampoo. They advise focusing on haircare, diet, and mental health after establishing a routine.

community KX-826 Phase 3 Failed. Sorry guys...

_The_Quiet_Place_ in Research/Science 51 upvotes 1 year ago

The conversation discusses the failure of Phase 3 trials for the hair loss treatment KX-826, with no significant difference found between the drug and placebo. Some users express disappointment and skepticism, while others discuss alternative treatments like Minoxidil, finasteride, and RU58841.

community Dermarolling and Min are proven to be the absolute best way to get new hairs, there is no comparison.

PM_ME_YOUR_SUNSHINE in Microneedling 127 upvotes 2 years ago

Fin and minoxidil, in combination with dermarolling, as an effective path for hair growth. The post also provides advice about needle depth and frequency, as well as other treatments (foam and oral) which may be beneficial.

community Update on the ol' crown (oral min/fin)

RealisticAbies9356 in Progress Pictures 1011 upvotes 1 month ago

Using 2.5mg oral minoxidil and 1mg oral finasteride daily leads to significant hair regrowth without side effects, especially at the crown. Consistency is crucial, and some users consider additional methods like derma rolling.

community The theory that explains everything - First Evidence of Hair regrow attributed to upregulating 3aHSD

joaopassos4444 in Treatment 175 upvotes 3 years ago

Hair regrowth treatment involving 3aHSD enzyme shows 6% improvement in 18 weeks. Sulforaphane, L-Menthol, and Dexpanthenol are potential ingredients for new hair loss solution.

community Finasteride won’t make all your problems go away

idhke in Finasteride/Dutasteride 323 upvotes 1 year ago

A user shared that while finasteride improved their hair, it didn't solve all their insecurities, suggesting that self-acceptance is key. Others in the conversation expressed varying opinions, with some feeling that finasteride significantly boosted their confidence and quality of life, while others acknowledged it as a solution to hair loss but not a cure-all for other personal issues.

community Pirfenidone - The answer to fibrosis and baldness

uttftytfuyt in Treatment 19 upvotes 3 years ago

Pirfenidone is suggested to treat fibrosis and baldness by blocking inflammation markers and reducing collagen. It is also available as a gel for scar removal.

community Minoxidil + Gym + Cutting. Is it bad?

pewdsVStseries in Minoxidil 38 upvotes 1 year ago

A user is concerned about weight loss stagnation while using minoxidil and finasteride during a calorie-cutting diet. Responses suggest water retention or a weight loss plateau as possible causes.

community My microneedling journey (no min, fin, etc)

silfy_star in Microneedling 210 upvotes 4 months ago

The user experienced positive hair growth results using microneedling with rosemary and mint oil, without Minoxidil, Finasteride, or RU58841. They switched from a dermaroller to a microneedling pen and targeted different scalp areas weekly.

community Serious question, is there nothing that can be done if Dutasteride doesn’t help to stop my hair loss?

AfterHighlight9327 in Finasteride/Dutasteride 61 upvotes 2 years ago

A 25 year old male who has been using finasteride and dutasteride for two years to treat his hair loss, with no success. Other treatments such as oral minoxidil, topical anti-androgens, RU58841, latanoprost, topical estrogen, CB 03 01, microneedling, keto 2% shampoo, vitamin D, Omega 3, B vitamins and probiotics were discussed.