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GlossaryPost-transcriptional regulation

control of gene expression after RNA is made from DNA

Post-transcriptional regulation refers to the control of gene expression after the DNA has been transcribed into RNA but before it is translated into proteins. This process includes modifications like RNA splicing, editing, transport, and stability, which ultimately influence how much protein is produced from a gene. For example, in hair biology, post-transcriptional regulation can affect the production of proteins involved in hair growth and maintenance, potentially impacting conditions like alopecia.

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community Fats on your Head to Stop Hair Loss?

in Research/Science 140 upvotes 6 months ago

The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

community TWIST-1 and the cure: Is it really that easy?

in Research/Science 283 upvotes 2 years ago

TWIST-1 gene's role in hair loss and potential as a treatment target. Inhibiting TWIST-1 may prolong hair growth and reduce hair follicle sensitivity to DHT.

community My Theory Regarding a Cause and Cure for Androgenetic Alopecia

in Treatment 100 upvotes 4 years ago

Hair loss theory suggests imbalance between Vitamin D Receptor (VDR) and Androgen Receptor (AR) activation. Proposed treatment includes upregulating VDR, downregulating AR, and improving mitochondrial health.

community My Testosterone results before and after Finasteride

in Update 149 upvotes 2 years ago

Finasteride significantly increased testosterone levels for the user, with no major side effects except watery semen, which was resolved with zinc supplements. The user's hairline stopped receding and slightly improved.

community DHT and 5AR respect post, it's importance within the brain

in Research/Science 109 upvotes 5 months ago

The conversation discusses whether to use finasteride for hair loss, considering its role in inhibiting DHT and 5AR, which can affect brain function and mood. Some users report anxiety and depression from finasteride, while others do not experience these side effects and emphasize the importance of DHT for brain and prostate health.

community So does oral minoxidil age your skin or not

in Minoxidil 40 upvotes 4 months ago

Oral minoxidil may cause dry skin and dark eye bags but doesn't significantly age the skin. Topical minoxidil is toxic to cats, and some users prefer finasteride.

community Adrogens and Covid-19

in Treatment 7 upvotes 4 years ago

The possible increased risk of severe Covid-19 cases in men due to higher androgen levels, and how taking medications such as finasteride, dutasteride, spironolactone, enzalutamide, or canabidiol might help mitigate the severity of the disease.

community HLT Megathread on HMI-115 (key takeaways in comments)

in Research/Science 38 upvotes 1 year ago

HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.

community Why is nobody studying the difference between donor and balding hair?

in Chat 88 upvotes 2 months ago

The conversation discusses why the difference between donor and balding hair isn't studied more to find a cure for hair loss. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 448 upvotes 3 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

community Testosterone in Reference Range Doesn't Cause Hair Loss

in Research/Science 52 upvotes 6 months ago

Testosterone within the normal range does not significantly contribute to male pattern baldness (MPB); DHT is the main factor that can be controlled. Genetics play a crucial role in hair loss, and treatments like finasteride and dutasteride, which block DHT, can help despite potentially raising testosterone levels.

community What happened to the ‘funding’ for broccoli research in treating hair loss?

in Chat 44 upvotes 2 years ago

Hair loss discussion includes broccoli sprouts treatment, Fluridil 7%, and sulforaphane, with mixed results. Finasteride, minoxidil, and RU58841 are preferred by some users.

community DHT/Testosterone levels in scalp Fin VS Dut.

in Finasteride/Dutasteride 63 upvotes 4 weeks ago

Dutasteride raises scalp testosterone by 99%, which may not be ideal for those sensitive to all androgens. Some argue finasteride's balancing act might be better, while others believe dutasteride is superior for hair regrowth.

community Progress: From June 2022 (7 months of min + fin) to now (1 year) — I’ve lost so much density in this period and I have no idea why. I was getting pretty good resultup until that point. Is there anything else I can try? I’ve tried min, fin, tretinoin, micro needling, and castor oil. I feel hopeless.

in Progress Pictures 12 upvotes 1 year ago

The user lost hair density after 7 months of using minoxidil and finasteride and is seeking advice on other treatments after trying tretinoin, microneedling, and castor oil. Suggestions include checking for scalp conditions like eczema or psoriasis, changing minoxidil brands, and questioning hair dryer use and finasteride dosage.

community Just had this wild thought come into my head.

in Satire 403 upvotes 5 months ago

The conversation is about the debate over the existence of Post-Finasteride Syndrome (PFS) and its symptoms, with some users skeptical about PFS and others discussing side effects like erectile dysfunction and gynecomastia from hair loss treatments like finasteride. Specific treatments mentioned include finasteride, viagra, and a joke about using a popsicle stick for erectile support.

community What's your option on complementary treatment

in Product 3 upvotes 2 months ago

The conversation discusses complementary treatments for hair loss while using finasteride and minoxidil, including scalp massagers, scrubs, coconut oil, and vitamin supplements. The user seeks opinions on these additional treatments.

community I find it funny a bunch of us on here are on drugs for hairloss and maintain clean/healthy lives and then there’s these mf’s in the 90’s juiced to the gills with steroids and have better hair than all of us lol

in Satire 353 upvotes 1 year ago

The conversation is about the effects of steroids on hair loss. Some users believe that steroids can cause hair loss, while others argue that it depends on individual sensitivity to DHT. There is also discussion about the appearance of balding individuals who use steroids.

community Going to try and reverse MPB naturally.

in Treatment 59 upvotes 2 years ago

A user is trying to reverse male pattern baldness (MPB) naturally by taking high doses of Vitamin D, improving diet, exercising, reducing stress, and other lifestyle changes, but plans to use finasteride if no results are seen in 60 days. Other users are skeptical, advising medical treatments like finasteride and warning against potential vitamin D overdose and the ineffectiveness of natural remedies for genetic hair loss.

community The most depressing things about hair loss for me

in Chat 24 upvotes 3 years ago

The emotional impact of hair loss and the risks associated with common treatments such as finasteride, dutasteride, minoxidil, RU58841, and Fluridil. People discussed their personal experiences with these treatments, including potential side effects and lowered fertility. Hair transplants were also mentioned as a possible solution.

community Two Great Articles on NCBI That Summarize What We Actually Know About Finasteride Side Effects

in Finasteride 80 upvotes 5 years ago

The side effects of taking finasteride as a treatment for hair loss, with particular focus on its sexual and psychiatric side effects; research has indicated that there are high and low outliers in terms of prevalence of sexual side effects, but it is usually between 3-5%, while evidence of lasting sexual side effects comes from lower quality sources.

community So it turns out Post Finasteride Syndrome was never real?

in Finasteride/Dutasteride 265 upvotes 2 weeks ago

Post Finasteride Syndrome (PFS) is debated, with some users reporting severe side effects from finasteride, while others believe these effects are rare or psychosomatic. Treatments discussed include finasteride, minoxidil, and RU58841.

community Post Finasteride Syndrome, A dangerous lie.

in Chat 142 upvotes 5 months ago

A user initially had side effects from finasteride, attributed them to anxiety and the nocebo effect, and after resuming the drug, experienced positive effects and now warns against misinformation about Post Finasteride Syndrome.

community Post Low-Level Laser Light Therapy Syndrome (PLLLTS )

in Satire 6 upvotes 1 year ago

Hair loss discussion includes LLLT treatments and a satirical condition called PLLLTS, causing patients to resemble lighthouses and attract moths. Some users express concern about others taking the satire seriously.

community POST ACCUTANE HAIR LOSS- Please help and leave your experiences and suggestions

in Female 10 upvotes 2 years ago

A user named Medical_Opinion8120, a 23-year-old female, is experiencing hair loss potentially due to a past accutane course. She has tried minoxidil without success and is currently taking iron and zinc supplements.

community Post about Treatments or Hair re-growth claims without pictures must be blocked

in Chat 160 upvotes 4 years ago

The need for people to provide pictures when making claims about hair re-growth treatments such as Minoxidil, Finasteride, and RU58841; and how these treatments can be beneficial to those with hair loss in terms of regaining a sense of control.

community Post Surgery Hairwash at H&W. Pre Flight.

in Transplants 58 upvotes 5 years ago

The conversation discusses the appearance of hair transplants immediately after surgery, noting that scars will be covered as hair grows. The original poster underwent both FUT and FUE procedures.

community 12M post-op +dutasteride daily / FUE 3000Hairs in Korea

in Progress Pictures 527 upvotes 1 month ago

A user shared progress pictures 12 months after a hair transplant and daily use of dutasteride. The conversation discusses the quality of comparison photos and the use of hair fibers.

community 6 years post transplant.. NO meds

in Transplants 779 upvotes 1 year ago

User had a hair transplant in 2016 but stopped taking finasteride due to side effect concerns. Now considering another transplant and starting finasteride, minoxidil, and microneedling to improve hair situation.

community 30% min cream nightly, 5% min mornings, fin, 1.5 derma pen weekly, .5 micro needling daily for min absorption, Daily multivitamin w/ Biotin, LLT every other day,daily scalp massages, Hims shampoo and daily coffee rinse. Hoping for some reversal. I’ll post update in 1 yr 5/15/2023. Wish me luck

in Product 11 upvotes 2 years ago

The post and conversation are about a hair loss treatment regimen involving 30% minoxidil cream nightly, 5% minoxidil in the mornings, finasteride, weekly 1.5 derma pen, daily 0.5 microneedling for minoxidil absorption, daily multivitamin with biotin, low-level laser therapy every other day, daily scalp massages, Hims shampoo, and daily coffee rinses. The user hopes for hair regrowth and plans to update in one year.

community the post about vitamin c and pH levels is legit.

in Update 13 upvotes 2 years ago

Using vitamin C in shampoo to adjust pH levels can improve hair health and reduce oiliness and dandruff. The user mixed vitamin C powder with conditioner, achieving positive results.