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    Did you mean Post-Inflammatory Hyperpigmentation?
    Glossary Post-Inflammatory Hyperpigmentation

    skin darkens after inflammation due to excess melanin production

    Post-Inflammatory Hyperpigmentation (PIH) is a condition where the skin becomes darker in color after an inflammatory event, such as acne, eczema, or a skin injury. This occurs because the inflammation triggers an overproduction of melanin, the pigment responsible for skin color, leading to dark spots or patches that can persist even after the initial inflammation has healed.

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      community Has anybody ever found out, what these hardened, tight spots on the scalp (where most balding takes place) are and how they appear and how to make the disappear?

      in Research/Science  9 upvotes 10 months ago
      The conversation discusses hair loss and treatments like finasteride, minoxidil, and ketoconazole shampoo. Users suggest scalp massages, warm showers, and other methods to address scalp tension and tight spots, with some mentioning the potential effects of medications like escitalopram and probiotics.

      community Peptides that Stop Hair Loss? | In-depth Literature Review Video

       76 upvotes 2 years ago
      Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

      community Increased Coffee intake resulted in massive shed

       17 upvotes 1 year ago
      Increased coffee intake might be linked to hair shedding, but the cause is unclear. The user is on finasteride and has increased water intake, possibly affecting electrolyte balance.

      community Post op day 1, My 10 year journey and thoughts about hair loss, advice

       6 upvotes 9 months ago
      The user shared their 10-year hair loss journey, discussing treatments like oral minoxidil, oral finasteride, and LLLT, and ultimately deciding on a hair transplant. They also explored the possibility of having alopecia areata incognita and advised seeking multiple opinions before surgery.

      community Microneedling protocol and supplements

      3 years ago
      Microneedling for hair loss should avoid anti-inflammatory supplements like garlic, Vitamin E, fish oil, turmeric, and NSAIDs for 3 days before and 5 days after the procedure to enhance collagen production. Completely abstaining from these supplements may be unnecessary, but caution is advised around the procedure time.

      community Reducing Fibrosis in Hair Loss: Topical Pirfenidone

       59 upvotes 5 months ago
      Topical pirfenidone is highlighted as an effective anti-inflammatory and anti-fibrotic treatment for hair loss, particularly in addressing perifollicular fibrosis, which may enhance the effectiveness of standard treatments like finasteride and minoxidil. The user also uses calcipotriol, MCT oil, ciclopirox shampoo, and benzoyl peroxide shampoo as part of their regimen.

      community Hair Loss “Cure” for Inflammation: Topical Roflumilast

      in Research/Science  32 upvotes 8 months ago
      Topical roflumilast is effective for reducing inflammation in various scalp conditions like seborrheic dermatitis, psoriasis, and eczema, but not proven to stop scarring alopecia. Alternatives like apremilast and Vtama are also discussed for their anti-inflammatory benefits.

      community Telogen Effluvium/Chronic TE and immune-related hair loss advice

       5 upvotes 8 years ago
      Chronic Telogen Effluvium can be managed by avoiding inflammatory foods, exercising, staying hydrated, and using supplements like krill oil, saw palmetto, or licorice root. Minoxidil is discouraged due to its cost and potential for worsening hair loss, while castor oil is recommended to strengthen hair roots and reduce shedding.

      community The Worst Hair Loss Condition You (MAY) have: LPP

       48 upvotes 2 years ago
      Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

      community Inflammation's surprising role in shrinking hair follicles and AGA

      in Technology  66 upvotes 4 months ago
      Inflammation plays a significant role in hair follicle miniaturization and androgenetic alopecia, with treatments like ketoconazole shampoo, minoxidil, and finasteride being used to address it. Users discuss the benefits of anti-inflammatory treatments and peptides like KPV, alongside traditional hair loss treatments, to improve scalp health and hair quality.

      community Fibrosing alopecia in a pattern distribution

      in Research/Science  14 upvotes 2 years ago
      A user has been experiencing hair loss for 4 years, with treatments like minoxidil, finasteride, and various supplements proving ineffective. They were diagnosed with fibrosing alopecia in a pattern distribution, a condition that may require a combination of anti-inflammatory and hair growth treatments.

      community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

       63 upvotes 2 years ago
      Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

      community Microneedling aftercare advice

       4 upvotes 4 years ago
      Microneedling aftercare involves using saline water instead of sea water, and avoiding hyaluronic acid due to its potential pro-inflammatory effects. Users suggest using jojoba oil as a carrier for essential oils like rosemary and lavender, and combining microneedling with minoxidil for better hair regrowth results.

      community Scalp Biopsy Results - Almost 2 Years Dutasteride, Still Worsening

      in Update  24 upvotes 1 year ago
      Dutasteride and finasteride are not effectively stopping hair loss for some users, despite long-term use. Some are considering or using RU58841, pyrilutamide, and other treatments like microneedling, while also managing seborrheic dermatitis with diet and topical solutions.

      community A Nuanced Look at Microdosing Topical Finasteride

       86 upvotes 2 years ago
      The conversation discusses using a low dose of topical finasteride to achieve hair benefits with minimal systemic exposure. Users share experiences and opinions on dosing, systemic buildup, and side effects of both topical and oral finasteride.

      community Why do I see so many people here recommend microneedling?

       109 upvotes 3 years ago
      The efficacy of microneedling for hair regrowth as either a stand-alone therapy or adjunct to Minoxidil, and whether Tretinoin is a safer and more effective option. Replies include personal accounts from users who have had success with microneedling in combination with minoxidil and peptide serums, as well as considerations of technique, depth, and potential scarring.

      community My 15+ Year Hair Loss Journey: DUPA, Recurrent Alopecia Areata, & different dosages of Min / Fin topicals - Advice needed on next steps.

       4 upvotes 1 week ago
      The user has been managing hair loss for over 15 years, using treatments like Minoxidil, Finasteride, and corticosteroids, while experiencing side effects and recurrent Alopecia Areata. They seek advice on progression and potential underlying conditions, questioning if their hair loss is due to an autoimmune issue beyond typical patterns.

      community A Short Recap on PP405 and AAD 2026

      in Update 5 months ago
      PP405 is a promising experimental topical treatment for alopecia that reactivates dormant hair follicles by targeting cellular energy, with large-scale trials planned for 2026. While it shows potential, it cannot regenerate permanently destroyed follicles, making hair transplants the only guaranteed solution for advanced baldness currently.

      community Yes your lifestyle and diet has its role in hair loss.

      in Chat  296 upvotes 1 year ago
      Diet and lifestyle changes can reduce hair shedding but won't regrow hair lost to genetic male pattern baldness. Treatments like finasteride and dutasteride are necessary for significant hair regrowth.

      community Any of you gym rats notice creatine hair loss?

       6 upvotes 4 years ago
      Creatine and heavy lifting may contribute to hair loss, but genetics play a significant role. Some users suggest treatments like finasteride and MSM powder to manage or prevent hair loss.

      community How many are hyper responders to Finasteride?

       6 upvotes 4 months ago
      The user experienced severe side effects from finasteride, including hormonal imbalances and cognitive issues, leading to a recommendation to stop its use. They plan to follow up with tests to rule out a pituitary tumor and are considering topical treatments as alternatives.

      community Testosterone in Reference Range Doesn't Cause Hair Loss

       52 upvotes 2 years ago
      Testosterone within the normal range does not significantly contribute to male pattern baldness (MPB); DHT is the main factor that can be controlled. Genetics play a crucial role in hair loss, and treatments like finasteride and dutasteride, which block DHT, can help despite potentially raising testosterone levels.

      community Severe dry eye: finasteride vs dutasteride

       8 upvotes 5 years ago
      Woman uses antiandrogens for hair thinning prevention, experiences severe dry eye with finasteride. Asks if dutasteride could be better despite potential for worse dry eye.

      community Dread shed with Minoxidil finally stopped. I got a great tip.

      in Minoxidil  10 upvotes 4 weeks ago
      The user experienced initial hair shedding with minoxidil but saw improvement with consistent use, applying it once daily, along with massages, fenugreek paste, a high-protein diet, and exercise. They avoided finasteride due to concerns about sexual side effects, while others shared mixed experiences with finasteride's impact on libido.