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GlossaryPhytochemicals (Plant compounds)

naturally occurring plant compounds with potential health benefits

Phytochemicals are naturally occurring compounds found in plants that can have health benefits. They are not essential nutrients like vitamins or minerals, but they can help protect against diseases and support overall health by acting as antioxidants, anti-inflammatory agents, and through other mechanisms. Examples include flavonoids, carotenoids, and polyphenols.

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community Found it. Sulforaphane, a phytochemical in broccoli sprouts, promotes hair growth (60% regeneration in mice) by accelerating the degradation of DHT.

112 upvotes 7 years ago

Sulforaphane, found in broccoli sprouts, promotes hair growth by degrading DHT. Users discuss its potential benefits and joke about unconventional application methods.

community New Treatments, and a Huge Group Buy with Lots of Research

in Research/Science 109 upvotes 1 year ago

A user is organizing a group buy for various compounds aimed at reversing hair loss and gray hair, and improving brain health and fat loss. The user has developed a treatment plan based on extensive research and is inviting others to participate, with the option to choose only the compounds they need.

community Surprisingly thorough study on He-Shou-Wu/Fo Ti

in Research/Science 14 upvotes 1 year ago

He Shou Wu (Fo Ti) extract was found to prolong the hair growth phase, inhibit 5-alpha-reductase (like finasteride), reduce androgen receptors, and increase growth factors, potentially outperforming minoxidil in recovering hair follicle size after DHT exposure. Two compounds, emodin and TSG, are identified as responsible for these effects and warrant further investigation.

community Is Sulforaphane really an option?

in Chat 7 upvotes 3 years ago

The conversation discusses the potential benefits of Sulforaphane for hair growth, with a suggestion to grow broccoli sprouts for the best results. One user doubts its effectiveness for hair loss but notes its anti-cancer and hormetic benefits.

community 1 Month Topical Minoxidil Only

in Progress Pictures 72 upvotes 1 year ago

The conclusion of the conversation is that the user plans to use topical minoxidil, ketoconazole shampoo, and a derma stamp for hair loss treatment. They also plan to start using finasteride in the next 2 months. Other users suggest using finasteride and a hair transplant for better results. The user appreciates the feedback and will continue posting progress.

community Is this enough to regrow my lions mane and if no what am I missing?

in Chat 1 upvotes 6 months ago

A user is trying to regrow hair using a natural approach without Minoxidil or finasteride, focusing on micro-needling, red light therapy, and various oils and serums. Other users suggest that medical treatments are more effective for male pattern baldness.

community Korean 2021 study shows efficacy of sulforaphane.

in Treatment 49 upvotes 2 years ago

Sulforaphane shows potential for hair regrowth, with users reporting reduced shedding and regrowth. Some users combine it with Minoxidil and finasteride for better results.

community Please stop looking for a natural way to stop your hairloss

in Chat 369 upvotes 3 years ago

No natural way to stop hair loss, pharmaceuticals only option. Users discuss Minoxidil, Finasteride, natural remedies, and healthy scalp importance.

community This guy claims stem cells fixed his balding

in Is this regrowth? 301 upvotes 1 year ago

A man who claimed to have regrown his hair using stem cell treatment, sparking a debate about its effectiveness and cost. Some users suggested he might be using other treatments or substances, while others shared their own experiences with stem cell therapy for hair loss.

community TWIST-1 and the cure: Is it really that easy?

in Research/Science 283 upvotes 2 years ago

TWIST-1 gene's role in hair loss and potential as a treatment target. Inhibiting TWIST-1 may prolong hair growth and reduce hair follicle sensitivity to DHT.

community This serum outperformed Minoxidil in a recent study. Please debunk

23 upvotes 5 years ago

A topical solution called "Multi-Peptide Serum for Hair Density" by The Ordinary Company, which contains several ingredients that are used in alternatives to Minoxidil and was found to have better results than 5% Minoxidil in a study. People who have tried it shared their experiences with the serum as well.

community 6 MONTH PROGRESS - NO CHANGE AT ALL - Minoxidil/Daily Dermarolling/Vitamine D3

in Progress Pictures 12 upvotes 1 month ago

The user saw no hair regrowth after six months using minoxidil, daily dermarolling, and vitamin D3. Many suggest adding finasteride or dutasteride for better results.

community Why is it barely impossible to find balding South Korean men

in Research/Science 244 upvotes 1 year ago

The post discusses the rarity of baldness among South Korean men. Users suggest this could be due to early treatment, high beauty standards, accessibility of healthcare, and genetics. Treatments like finasteride and dutasteride are commonly used, and hair transplants are also popular.

community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

in Research/Science 732 upvotes 2 years ago

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

community So what’s really the deal with dutasteride hairline ruining claims?

in Finasteride/Dutasteride 72 upvotes 2 years ago

The potential effects of dutasteride on hair loss, with some users reporting it improved their hairline while others experienced worsened hair loss or shedding. Other treatments discussed include minoxidil and finasteride, as well as RU58841.

community Going to try and reverse MPB naturally.

in Treatment 55 upvotes 2 years ago

A user is trying to reverse male pattern baldness (MPB) naturally by taking high doses of Vitamin D, improving diet, exercising, reducing stress, and other lifestyle changes, but plans to use finasteride if no results are seen in 60 days. Other users are skeptical, advising medical treatments like finasteride and warning against potential vitamin D overdose and the ineffectiveness of natural remedies for genetic hair loss.

community Aronia Chokeberry and Cyanidin 3-O-arabinoside for Hair Growth (AGA) Study

in Research/Science 14 upvotes 9 months ago

A natural compound called C3A from Aronia Chokeberry can help prevent hair loss by counteracting the effects of DHT. The user has been taking 50 grams of dried organic Aronia Chokeberry daily for 30 days and will update with photos in 60 days.

community Began An Intensive Protocol but it's now all habit.

in Hair Systems 2 upvotes 2 years ago

The user follows an intensive hair loss protocol including dutasteride, biotin, black tea, pumpkin seed oil, peppermint shampoo, rosemary conditioner, mukemame, soy milk, lycopene, garlic, magnesium, chamomile, spicy food, citrus bergamot, zinc, multivitamins, kefir, and Greek yogurt. They plan to alternate between pumpkin seed oil and safflower oil and will share before and after pictures.

community My Last Post on this Subreddit: Nuclear Option

in Chat 27 upvotes 1 year ago

User starts final hair loss regimen with various treatments and plans to leave subreddit for mental health. Others believe user's hair is fine and the regimen is unnecessary and potentially harmful.

community Topical Dutasteride 0.1% and Dutasteride Mesotherapy 0.01% - 6 months

in Treatment 15 upvotes 2 years ago

Topical Dutasteride 0.05% twice a week and Dutasteride Mesotherapy 0.01% once a week showed noticeable improvement in hair loss over six months without side effects. The user plans to add Minoxidil tablets 2.5mg daily to their treatment.

community I’m Quitting ketoconazole shampoo

in Ketoconazole 2 upvotes 6 months ago

A user is quitting ketoconazole shampoo, believing it worsened their hair condition, and plans to use clarifying, keratin, and pH balanced moisturizing shampoos instead. Another user suggests using conditioner after ketoconazole to prevent dryness.

community No side effects on pyrilutamide / KX-826 so far

in Research/Science 207 upvotes 3 years ago

User TopBack56 and friends tried pyrilutamide (KX-826) for hair loss without experiencing negative side effects. They observed fine vellus hairs but no thick hair growth yet, and plan to add GT20029 to their regime after safety trials.

community The theory that explains everything. Please help me make this big!

in Research/Science 2453 upvotes 3 years ago

The post and conversation are about the role of the enzyme 3alpha-hydroxysteroid reductase in hair loss and the potential of compounds like procyanidin B2 and sulforaphane to boost its activity for hair regrowth. Further research is needed to develop effective treatments based on this theory.

community 4.5 month hair transformation with HOMEMADE topical solution. Saying bye to the Norwood reaper.

in Progress Pictures 128 upvotes 5 months ago

A user shared their 4.5-month hair transformation using a homemade topical solution with 5% minoxidil and crushed finasteride pills, applied twice daily with weekly microneedling. They plan to switch to once-daily application with tretinoin gel to enhance absorption.

community Hair came back in 3 months at 39y/o.

in Progress Pictures 421 upvotes 1 year ago

A user shared their successful hair regrowth using a combination of minoxidil, caffeine, biotin, and RU58841, along with weekly dermarolling. However, others advised against the user's plan to switch to rosemary oil and microneedling only, emphasizing the importance of continuing the current treatment to maintain the results.

community Hair loss treatments rated (by gpt-4)

in Research/Science 252 upvotes 1 year ago

Rating treatments for hair loss, with the help of GPT-4, according to efficacy, evidence and tolerability; a combination of chemicals from research papers, custom compounds, and some suggestions from other users were included.

community Topical Dut Compound Journal (Strut Pharmacy) - Starting next week. Need YOUR feedback!

in Finasteride/Dutasteride 8 upvotes 3 years ago

The user, on testosterone replacement therapy, found finasteride and minoxidil ineffective for hair loss. They are trying a new topical gel with dutasteride, tretinoin, and a higher concentration of minoxidil, and plan to document the results.

community GT20029 China Phase II Trial For AGA Reached Primary Endpoint

in Research/Science 136 upvotes 7 months ago

The GT20029 tincture, a topical androgen receptor degrader, showed significant hair growth and good safety in a China Phase II trial for male androgenetic alopecia (AGA), with the 1% dose twice weekly identified as optimal. The company plans to initiate Phase III trials in China and Phase II in the U.S., and the treatment also shows promise for acne.

community Why you should use 0.5mg Dut instead of 1mg Fin

in Finasteride/Dutasteride 45 upvotes 2 years ago

The comparison of 0.5mg dutasteride and 1mg finasteride for treating hair loss in men with androgenetic alopecia, with discussion of which is more effective and has fewer side effects.

community Natural Remedies: Polyphenols and Hair Loss

19 upvotes 5 years ago

Natural remedies to treat hair loss, such as polyphenols, apple peel extract, grape seed extract, green tea extract, peppermint oil, pumpkin seed oil, apigenin, Ginkgo biloba, red clover extract, olive leaf extract, Ecklonia Cava and Grateloupia elliptica. In addition, terpenes, carotenoids, and tocopherols were discussed as potential treatments.