Potential side effects of 5AR inhibitors like finasteride and dutasteride. Users debate risks, benefits, and personal experiences with these hair loss treatments.
Creatine may increase scalp DHT without affecting serum DHT, potentially speeding up male pattern baldness (MPB) for those genetically prone. Treatments mentioned include Minoxidil, finasteride, and RU58841.
The conversation discusses the pros and cons of dutasteride for male pattern baldness, with a focus on its long half-life. The user, a physician, also mentions that switching from finasteride to dutasteride can cause temporary hair loss until dutasteride reaches effective levels or accelerates the hair cycle.
Someone's brother tried Platelet-rich plasma (PRP) for hair loss; it had minimal effect on hair but improved skin appearance. Microneedling at home was suggested as a more sustainable alternative.
User experienced hair loss after taking creatine with finasteride for 8 years. Others shared similar experiences, but some suggested it could be a minoxidil shed.
Hair loss prevention and regrowth regimen includes finasteride, oral minoxidil, stemoxydine, hair growth serum, derma rolling, and ketocanazole shampoo. Users discuss efficacy, safety, and personal experiences with treatments.
A user underwent a 5000 graft hair transplant in Istanbul, which included 900 beard grafts, after previously using finasteride with limited success. The procedure cost £4500, including transport and aftercare in both Istanbul and the UK.
The conversation discusses whether to use finasteride for hair loss, considering its role in inhibiting DHT and 5AR, which can affect brain function and mood. Some users report anxiety and depression from finasteride, while others do not experience these side effects and emphasize the importance of DHT for brain and prostate health.
The conversation discusses whether creatine causes hair loss for those using finasteride or dutasteride, with some suggesting creatine might increase DHT or upregulate androgen receptors, potentially leading to hair loss. Others argue the evidence is not conclusive, citing limited studies and personal anecdotes, with some avoiding creatine as a precaution.
A 21 year old who has been taking various treatments for hair loss such as dutasteride, RU58841, minoxidil and finasteride with no results. Other users share their experiences of dealing with hair loss at an early age and offer advice on how to cope.
User shared 1-year progress using finasteride and minoxidil, thanking others for the recommendation. Many congratulated the user, while some asked about dosages and shared their own experiences with the treatments.
Finasteride can impact neurosteroids, potentially causing depression and other side effects in some users. Despite these concerns, many continue using it for hair loss, with some switching to topical applications to mitigate side effects.
The conversation is about the difference in hair loss between bodybuilders in the "Golden Era" and modern bodybuilders. Some users speculate that factors such as the types and doses of steroids used, genetics, diet, microplastics, and overall health may contribute to hair loss. Hair loss prevention medication and transplants are mentioned as potential treatments.
A user's transformation from an accountant to a spartan with a full beard, discussing the potential of DUPA and alopecia areata, as well as treatments like vitamins, topicals, and natural treatments for potential regrowth.
DHT Itch and its link to balding, with various treatments such as finasteride being discussed. Members shared their experiences of scalp itch before and after taking 5AR inhibitors, and potential underlying causes such as seborrheic dermatitis were discussed.
A medical student experienced hair loss slowing with Finasteride but developed severe, treatment-resistant insomnia. They tried various medications with little effect, suspecting Post-Finasteride Syndrome, and others suggested the insomnia might be linked to Finasteride's impact on neurosteroids.
The user experienced side effects commonly attributed to Finasteride without ever taking the drug, suggesting these issues may stem from other life factors. They advise considering other potential causes before blaming Finasteride for such side effects.
FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.
Dutasteride promotes more hair regrowth than Minoxidil. Users discuss combining treatments for better results and share personal experiences with side effects.
The conversation is about a user sharing their blood test results and questioning if it's okay to start a hair loss treatment with finasteride. Specific treatments mentioned are Minoxidil, finasteride, and RU58841.
A user has been using minoxidil for hair loss and has seen positive results, but is seeking additional treatments to enhance its effects. One suggestion given is to use finasteride alongside minoxidil.
The user is using finasteride and minoxidil for hair loss but is looking for new treatments. Pyrilutamide and GT20029 are potential future treatments, with Pyrilutamide expected next year and GT20029 possibly by 2027.
A user discusses a company, Roots by Genetic Arts, that offers a genetic test for hair loss to create personalized treatments, and is curious about its legitimacy and the science behind it. The company tests 16 genes related to hair loss and compounds a topical treatment based on the results.
Experimenting with trestolone as a treatment for hair loss in an attempt to avoid DHT-related treatments such as finasteride and dutasteride, and discussing the potential effects of its receptor selectivity on the androgen receptors in the scalp.
A user convinced their 45-year-old dad to use minoxidil and finasteride, resulting in significant hair regrowth. The dad now uses 1mg of finasteride daily and topical minoxidil twice a day, and has also started using 1% ketoconazole shampoo.
A 27-year-old considering a hair transplant after going bald from 2018 to 2024. Recommendations include using finasteride and minoxidil before the transplant, with mixed opinions on their long-term use and side effects.
A user shared their 9-month progress using Propecia and minoxidil for hair loss, noting significant daily shedding. Others suggested potential vitamin/mineral deficiencies and offered encouragement.
Biotin is being misleadingly marketed as a primary treatment for androgenic alopecia, overshadowing more effective treatments like finasteride and minoxidil. There is a call for increased awareness and accountability to prevent misinformation.
The post and conversation are about the user's high testosterone levels and their worsening hair loss despite trying various treatments. They are considering using low doses of anti-androgens to lower their testosterone levels as a potential solution.
A user discusses starting nandrolone replacement therapy to stop hair loss and improve hair health, noting its benefits over finasteride. They report halted hair loss, improved skin, increased muscle, and a calm mood after three weeks.