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GlossaryPharmacology

branch of science studying drug interactions with biological systems

Pharmacology is the branch of science that studies how drugs interact with biological systems. It involves understanding the effects of medications on the body, how they are absorbed, distributed, metabolized, and excreted, as well as their therapeutic and toxic effects. This field is crucial for developing new medications and ensuring their safe and effective use.

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community Is 2-deoxy-D-ribose (2dDR) good for human hair?

in Research/Science 9 upvotes 3 months ago

Topical 2-deoxy-D-ribose (2dDR) regrows hair in mice almost as well as 2% Minoxidil. However, 2dDR may contribute to oxidative stress and hair loss due to the formation of advanced glycation end products (AGEs).

community This is what some balding dudes are like

in Satire 1050 upvotes 1 month ago

Some people avoid finasteride due to side effects but engage in unhealthy habits. Minoxidil and finasteride are common hair loss treatments, with varied side effect experiences.

community Finasteride vs Dutasteride: The Science

in Research/Science 170 upvotes 11 months ago

The conversation compares Finasteride and Dutasteride for hair loss treatment, discussing their effectiveness and side effects. Users share personal results and consider combining treatments like Dutasteride with RU58841.

community 2 years later I managed to gain some ground (Hyperresponder)

in Progress Pictures 43 upvotes 1 year ago

The user regained most of their hair using Minoxidil, Finasteride, and Dermarolling. They found Dermarolling particularly effective, as it promotes growth factors and improves hair thickness.

community Stop Using Salicylic acid on your face if using minoxidil for beard growth

in Product 20 upvotes 6 months ago

Salicylic acid can reduce the effectiveness of minoxidil for beard growth. Users discuss avoiding salicylic acid when using minoxidil.

community [Research] RU-58841/Pyrilutamide and impacts on male fertility

in Research/Science 6 upvotes 1 year ago

The drugs RU-58841, Pyrilutamide (KX-826), Apalutamide, Enzalutamide, and Darolutamide, which are nonsteroidal antiandrogens (NSAA), potentially impacting male fertility. Pyrilutamide, similar to Enzalutamide, may have reversible effects on fertility.

community Oral Minoxidil and Grapefruit Juice

in Research/Science 96 upvotes 1 year ago

The conversation is about the potential dangers of taking oral minoxidil and grapefruit juice together. Some users express concern about dangerous drug interactions, while others argue that grapefruit juice may inhibit the metabolism of finasteride. The conclusion is that grapefruit juice may make finasteride less effective, but it won't affect minoxidil.

community My dermatologist uses oral minox and dutasteride

in Minoxidil 65 upvotes 2 years ago

Treatments for hair loss and the potential side effects. The user discussed their doctor's advice to take 1.25 mg oral minoxidil and .5 mg dutasteride daily, with a warning that those with heart conditions should not take oral minoxidil. Other users shared their experiences, including taking finasteride and noting the possible overkill of the dosage prescribed by Jirons1's dermatologist.

community KX-826: Long-Term Safety Results are out!

in Research/Science 156 upvotes 2 months ago

KX-826 initially improves hair growth but declines after 24 weeks, with mild itching as a side effect. Combining it with minoxidil and finasteride may improve results, but long-term effectiveness is uncertain.

community Science backed answer only from what you have learnt .

in Chat 6 upvotes 2 months ago

Alcohol-based minoxidil absorbs better but can cause irritation; non-alcohol-based is gentler. Topical dutasteride shows promise but needs more research; low-dose oral minoxidil (0.25 mg/day) is effective with fewer side effects. Ingredients like Procapil, Redensyl, caffeine, and Anagain in shampoos have limited evidence; ketoconazole shampoo can help when used 2-3 times a week with other treatments.

community We Need A Solution For The Inflammatory Response related To AGA

in Research/Science 16 upvotes 3 months ago

The conversation is about finding a solution for scalp inflammation related to AGA, with the user expressing frustration that Minoxidil and Finasteride do not address inflammation. The user has researched glucocorticoids and topical NSAIDs for reducing inflammation and seeks advice from specialists.

community New update. 16 months on finasteride, 25 year old, 1.25mg daily. The first picture is a screenshot from a video taken in February 2023, hence the quality is kinda poor.

in Progress Pictures 418 upvotes 6 months ago

A 25-year-old user shared progress pictures after 16 months of using 1.25mg daily finasteride for hair loss, reporting noticeable results around months 4-5 and some initial side effects that resolved. The user experienced thickening and slight regrowth of the hairline.

community Why isn't anybody on topical bicalutamide?

in Research/Science 2 upvotes 6 months ago

Topical bicalutamide is discussed as a potential hair loss treatment. Other treatments mentioned include Minoxidil, finasteride, and RU58841.

community Is too much Zinc actually bad?

in Research/Science 2 upvotes 7 months ago

Taking too much Zinc, around 30mg per day, might cause hair loss. The user is also using 0.5mg Dutasteride and 2.5mg Oral Minoxidil daily.

community Fun thought experiment about halting hair loss permamently

in Research/Science 58 upvotes 7 months ago

A user proposed genetically engineering scalp stem cells to stop androgen receptors from causing hair loss. Others discussed the feasibility, existing research, and potential issues with this approach, including targeting the correct cells and unintended effects.

community Possible explanation of why Dutasteride seems to be worse for some people’s hair.

in Treatment 47 upvotes 1 year ago

The conclusion of the conversation is that some individuals may experience a condition called reactionary hypergonadism when taking dutasteride for hair loss. This condition can lead to an increase in testosterone levels, which may worsen hair loss instead of improving it.

community Sharing my (relatively short) Success Story

in Progress Pictures 77 upvotes 1 year ago

A user named "paulsac11" shares their success story of treating hair loss. They started with topical minoxidil, then switched to oral minoxidil and dutasteride. They also used a shampoo and conditioner from Keeps. After eight months of treatment, they have seen significant improvement in their hairline.

community Dutasteride is my last Hope ??

in Finasteride/Dutasteride 16 upvotes 1 year ago

User tried topical and oral finasteride and oral minoxidil for hair loss without success. ButterscotchSea3159 suggests using Dutasteride, oral minoxidil, ketoconazole shampoo, microneedling, and possibly RU for better results.

community You Long term fin users, how are y’all going 10 or 15 years down the road? Does it actually work for most people?

in Finasteride/Dutasteride 46 upvotes 2 years ago

Long-term finasteride users report maintaining hair and experiencing regrowth, with some using it for over 20 years. Combining finasteride with minoxidil or hair transplants can improve results.

community Dutasteride (.5mg) is some strong stuff!

in Finasteride/Dutasteride 58 upvotes 3 years ago

User switched from finasteride and minoxidil to dutasteride, experienced side effects, then took dutasteride once a week with improved hair density. Another user had success with daily dutasteride, while one had no results from topical dutasteride.

community 1 year results. Fin + Min + Microneedling + tretinoin + ketoconazole

in Progress Pictures 208 upvotes 3 years ago

A user's 1 year progress using a combination of treatments, including Minoxidil BID, finasteride, microneedling, tretinoin, and ketoconazole shampoo, for hair loss. Replies included advice such as to consider switching the strength of minoxidil or getting a shorter haircut.

community Why haven’t we seen anything about this

in Research/Science 18 upvotes 4 years ago

A double blind, placebo-controlled study that looked into the potential effectiveness of topical fluridil for treating male androgenetic alopecia, showing increased anagen to telogen ratios with no reported side effects on libido or sexual performance.

community Only 10 more days until cassiopea releases their 12 month results for CB-03-01 our best hope of an alternative to finasteride

in Finasteride 155 upvotes 5 years ago

The conversation discusses anticipation for CB-03-01, a potential new hair loss treatment that may be more effective and have a cleaner safety profile than finasteride. Users are hopeful but cautious, discussing current treatments like minoxidil, nizoral, and dermarolling, and the possibility of combining them with CB-03-01 for better results.

community 3 years on Finasteride and Minoxidil. Final progress update before FUE Procedure this weekend. Updates to follow!

in Progress Pictures 389 upvotes 3 days ago

The user shared their three-year progress using finasteride and minoxidil for hair regrowth before undergoing a hair transplant procedure. They plan to continue the medication post-procedure due to its success and did not experience significant side effects.

Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

in Research 413 upvotes 2 weeks ago

Treating androgenic alopecia with minoxidil, finasteride, and antiandrogens, alongside exercise, cryotherapy, and natural substances to stimulate cold receptors for better hair growth. The method focuses on enhancing treatment effectiveness by considering environmental and behavioral factors and the role of cold receptors and muscle stress.

community Research Backed Dutasteride Simulator (Serum/scalp DHT included for all doses)

in Research 487 upvotes 4 weeks ago

A Dutasteride Simulator predicts serum dutasteride, serum DHT, and scalp DHT levels using models from research papers. It simulates various dosing schedules to determine steady-state effects and visualizes outcomes, including hair growth-related scalp DHT suppression.

community Research Backed Dutasteride Simulator (Serum/Scalp DHT included for all doses)

in Finasteride/Dutasteride 95 upvotes 4 weeks ago

A dutasteride simulator predicts that daily 0.5 mg dosing results in higher DHT suppression compared to less frequent dosing. Twice-weekly dutasteride may be as effective as finasteride 5 mg, providing a balance between efficacy and ease of use.

community He used Dutasteride for 20 years. Interview

in Treatment 109 upvotes 1 month ago

Dutasteride has been used for 20 years with some hair thickness improvement but no dramatic regrowth. The user also experimented with minoxidil, tretinoin, and peptides like BPC 157 for potential benefits in hair density and quality.

community What's "wrong" with oral minoxidil, exactly?

in Minoxidil 173 upvotes 2 months ago

Oral minoxidil can boost hair growth but may cause side effects like heart palpitations and increased body hair. Many prefer topical minoxidil due to fewer side effects.

community Be careful when switching from Finasteride to Dutasteride because for more efficacy.

in Finasteride/Dutasteride 13 upvotes 2 months ago

Switching from finasteride to dutasteride may be more effective for hair regrowth due to dutasteride's stronger enzyme inhibition, but combining both drugs could enhance results. Some users report better outcomes with dutasteride, while others recommend a gradual transition to prevent potential hair loss.