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GlossaryPlasminogen Activator Inhibitor-1 (PAI-1)

regulates blood clot breakdown by inhibiting plasminogen conversion enzymes

Plasminogen Activator Inhibitor-1 (PAI-1) is a protein that regulates the breakdown of blood clots by inhibiting enzymes that convert plasminogen to plasmin, which is responsible for clot degradation. Elevated levels of PAI-1 are associated with an increased risk of thrombosis and various cardiovascular diseases, as it can lead to excessive clot formation.

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community Insane MTF recovery 18 months blocking androgens

in Progress Pictures 145 upvotes 1 year ago

Hair loss recovery using estrogen and anti-androgen treatment for 18 months showed significant improvement. However, results vary and alternative treatments like RU58841 and Dutasteride may work without systemic feminization.

community Initial thoughts on the Happy Head SuperCapsule (oral min/fin and oral min/dut compounds)

in Treatment 6 upvotes 1 year ago

The user noticed increased hair fullness after using a minoxidil and finasteride oral capsule but is unsure if the 1.25 mg minoxidil dose is sufficient. They are considering switching to a higher dose and are waiting for a dermatologist's advice.

community How well can HRT reduce scalp tension?

in Transgender 6 upvotes 1 year ago

A trans woman is curious about the impact of HRT on hair regrowth and scalp tension. Her current regimen includes finasteride, spironolactone, estradiol, ketoconazole, vitamin D, iron, and plans to add oral minoxidil and restart derma rolling.

community Anyone is going to test if verteporfin work in the upper area or demaroller + verteporfin?

in Technology 17 upvotes 1 year ago

The conversation is about the interest in testing verteporfin, potentially with a dermaroller, for hair loss treatment. There is frustration over the lack of group buys for promising treatments compared to past efforts with less evidence.

community GT20029 Anageninc Market Availability

in Research/Science 164 upvotes 1 year ago

The conversation discusses the potential market release of a hair loss treatment called GT20029 by Anageninc, with users expressing interest and discussing the importance of safety and effectiveness. Some users plan to contact Anageninc to show demand for the product.

community AnagenInc says GT20029 is possible now

in Research/Science 117 upvotes 1 year ago

AnagenInc is ready to produce a hair loss treatment called GT20029 if there is enough demand. People are discussing combining it with other treatments like finasteride and minoxidil, and some are concerned about the legitimacy and safety of gray market products.

community What factors cause more regrowth for MTF people with hormone replacement therapy?

in Transgender 6 upvotes 1 year ago

Hair regrowth in transfems is more effective due to hormonal changes, specifically estrogen, which keeps hair in growth phase longer. Treatments mentioned include anti-androgens, sex hormones, and DHT blockers like finasteride.

community New Treatments, and a Huge Group Buy with Lots of Research

in Research/Science 109 upvotes 1 year ago

A user is organizing a group buy for various compounds aimed at reversing hair loss and gray hair, and improving brain health and fat loss. The user has developed a treatment plan based on extensive research and is inviting others to participate, with the option to choose only the compounds they need.

community RU users hands up I wanna hear your miracolous and horror stories.

in Treatment 44 upvotes 1 year ago

The experiences of users who have used RU58841 to treat hair loss, including both positive and negative effects. Some side effects reported include chest pain, joint pain in the hands, tinnitus, and increased heartbeat.

community New drug for hair loss announced by Amplifica

in Research/Science 161 upvotes 1 year ago

Amplifica starting clinical trials for new hair loss drug. SCUBE3 protein discovered, stimulates hair growth, could be alternative to Minoxidil and Finasteride.

community 21F AGA - 4 month hair growth progress (Minoxidil 5%, finasteride 1mg, theradome LLLT, viviscal vitamins, PRP twice)

in Progress Pictures 256 upvotes 2 years ago

A 21-year-old female shared her 4-month hair growth progress using Minoxidil 5%, finasteride 1mg, Theradome LLLT, Viviscal vitamins, and PRP treatments twice. Commenters praised her progress and discussed other treatments like microneedling, but she noted her dermatologist advised against it due to potential scalp damage.

community Three years + or - on the Big 3. Plus Biotin.

in Progress Pictures 663 upvotes 3 years ago

The conversation discusses a user's hair regrowth over three years using Minoxidil, Finasteride, and a hair transplant, along with Biotin supplementation. Some users question the authenticity of the results and the organization of the before-and-after photos.

community 27m gone bald, hair in 2018 to no hair 2024 considering HT

in Shaved/buzzed 172 upvotes 5 months ago

A 27-year-old considering a hair transplant after going bald from 2018 to 2024. Recommendations include using finasteride and minoxidil before the transplant, with mixed opinions on their long-term use and side effects.

community I really hate how current hair loss treatment only rely on DHT blockers

in Finasteride/Dutasteride 76 upvotes 1 year ago

The conversation discusses dissatisfaction with current hair loss treatments that mainly focus on DHT blockers like finasteride and dutasteride. Alternative treatments mentioned include RU58841, pyrilutamide, minoxidil, rosemary oil, and future possibilities like hair cloning.