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GlossaryOral JAK Inhibitors

medications taken orally that block Janus kinase enzymes

Oral JAK Inhibitors, also known as oral Janus kinase inhibitors or oral JAKis, are medications taken by mouth that block the activity of Janus kinase enzymes. These enzymes play a key role in the signaling pathways that regulate immune responses and inflammation. By inhibiting these enzymes, oral JAK inhibitors can help manage autoimmune conditions and inflammatory diseases, including certain types of alopecia, by reducing abnormal immune activity.

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community What else is good. Besides the big 3.

in Chat 36 upvotes 1 month ago

Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

community 8 months apart on the mother of all stacks

in Progress Pictures 151 upvotes 1 year ago

User Tricky9555 tried various hair loss treatments for 8 months with no visible results. Others suggested considering a hair transplant, checking thyroid levels, and being patient for up to 24 months for potential results.

community Is it ok to take Xeljanz (A jak inhibitor) while taking finasteride?

in Finasteride 2 upvotes 7 years ago

The conversation is about whether it is safe to take Xeljanz, a JAK inhibitor, while also taking finasteride for hair loss. The concern is that Xeljanz weakens the immune system, which could be risky.

community Oral minoxidil 2.5 mg since end of July 2024 till November 2024

in Is this regrowth? 464 upvotes 1 week ago

Oral minoxidil has shown positive results for hair regrowth, but concerns about its side effects, such as heart issues, are noted. Adding a DHT blocker like finasteride is recommended for better and more lasting results.

community Oral minoxidil or topical with tretinoin?

in Minoxidil 5 upvotes 2 weeks ago

The conversation discusses the effectiveness of oral minoxidil versus topical minoxidil with tretinoin for hair regrowth, with some users suggesting oral minoxidil might be more effective for non-responders to topical treatments. Concerns about side effects and the role of enzymes in activating minoxidil are also mentioned.

community Is microneedling + minoxidil better than oral minoxidil

in Chat 29 upvotes 3 weeks ago

Oral minoxidil is considered more effective for hair regrowth than topical minoxidil, but it carries higher risks. Combining microneedling with topical minoxidil can enhance absorption, but oral minoxidil with microneedling shows significant results.

community Oral min and ru 🙏let’s hope these go terminal

in Is this regrowth? 1 month ago

The conversation discusses hair regrowth using oral minoxidil and RU58841, with visible baby hairs appearing after two months. One user questions the choice of RU58841 over finasteride.

community Oral min vs topical comparison

in Treatment 10 upvotes 1 month ago

Oral minoxidil is claimed to be more effective and easier to use than topical minoxidil, with a 100% response rate, but it may cause unwanted body hair growth and has potential heart-related side effects. Topical minoxidil is less effective for many due to enzyme limitations, can cause scalp issues, and is more challenging to apply, but it avoids systemic side effects.

community What's "wrong" with oral minoxidil, exactly?

in Minoxidil 173 upvotes 1 month ago

Oral minoxidil can boost hair growth but may cause side effects like heart palpitations and increased body hair. Many prefer topical minoxidil due to fewer side effects.

community Oral Biotin and Topical Minoxidil have a synergy effect in increasing hair growth, the study was only done in healthy subjects and it was only 14 days but it does prove that biotin can play a significant role as an adjunct treatment.

in Research/Science 170 upvotes 1 month ago

Oral biotin combined with topical minoxidil may increase hair growth rate, though the study was limited to healthy subjects and did not measure hair density. Some users report personal benefits from biotin, such as faster nail growth and healthier hair, but concerns about acne and study quality were also mentioned.

community Oral minoxidyl and topical minoxidyl

in Minoxidil 2 upvotes 1 month ago

Using both oral and topical minoxidil is likely safe, but be cautious of increased systemic absorption. The best tretinoin dosage to enhance minoxidil effectiveness is not specified.

community Oral 0.5mg dut + 2mg min 4 months. Topical 5% min since february.

in Is this regrowth? 41 upvotes 1 month ago

The user has been using oral dutasteride 0.5mg, oral minoxidil 2mg, and topical minoxidil 5% for hair regrowth, along with microneedling. They have seen significant hair coverage improvement and are considering additional supplements for better results.

community Is Tretinoin gel useful with Oral Minoxidal?

in Minoxidil 7 upvotes 1 month ago

Oral minoxidil and finasteride are the main treatments for hair loss, with microneedling as an additional method. Tretinoin gel is not necessary with oral minoxidil but can be used for skincare.

community Theory As To Why Oral Minoxidil Might Be Helpful To People Compared To Topical Minoxidil

in Minoxidil 8 upvotes 1 month ago

Oral minoxidil may be more effective than topical due to uniform distribution and systemic activation, but can cause side effects like puffiness. Adding tretinoin to topical minoxidil can enhance its effectiveness by aiding conversion to its active form.

community Failure with 5mg oral minoxidil, looking for experiences of people who used topical with glycerin as a vehicle.

in Minoxidil 6 upvotes 1 month ago

Oral minoxidil was ineffective for OP, causing hair loss and unwanted body hair, while topical minoxidil showed significant regrowth. OP is switching to topical minoxidil with glycerin due to scalp issues with propylene glycol.

community Oral Minoxidil Eyelashes Are Insane

in Minoxidil 288 upvotes 2 months ago

Oral minoxidil can significantly increase eyelash length and thickness. Users report mixed results on hair growth, with some experiencing increased body hair.

community Oral Minoxidil worse hair after 1 year

in Progress Pictures 41 upvotes 2 months ago

The user switched from topical to oral Minoxidil and Finasteride but saw no improvement after a year, with hair appearing thinner. They recently switched to Dutasteride, hoping for better results.

community Oral minoxidil 6 months update. Have I beaten the reaper yet?

in Satire 680 upvotes 3 months ago

The post and conversation discuss a user's 6-month update on using oral minoxidil for hair loss, with humorous and satirical replies. Some comments suggest discontinuing due to side effects.

community Oral or topical finasteride? .

in Chat 12 upvotes 3 months ago

A user is deciding between oral and topical finasteride for hair loss, noting oral finasteride's ease of use but broader effects. Another user simply recommends oral finasteride.

community Oral vs Topical Finasteride for Trans Women

in Transgender 3 months ago

A user is using a Finoxidil topical spray and is curious if oral Finasteride would be more effective, considering they are already on a DHT blocker called Cyproterone. They are concerned about the potential impact of oral Finasteride on their transition.

community Oral min and Isotretinoin (accutane) to respond

in Chat 3 months ago

Oral minoxidil combined with isotretinoin may improve hair loss treatment effectiveness. Tretinoin is known to increase the absorption of topical minoxidil.

community Oral Minoxidil in Europe (10 mg)

in Minoxidil 9 upvotes 3 months ago

The user is seeking oral Minoxidil in Europe due to issues with topical Minoxidil causing dandruff and dry scalp. They have started using oral Finasteride and are considering Ketoconazole shampoo.

community Oral minoxidil dosage timing. And Is tretinoin a gamechanger?

in Chat 2 upvotes 4 months ago

The user is considering splitting their 5 mg oral minoxidil dose into two 2.5 mg doses and is asking about starting tretinoin on the scalp, questioning if it should be used alone initially or with topical minoxidil. They also inquire if tretinoin significantly improved their hair loss treatment.

community What blood exams should I do on dut/oral min

in Chat 1 upvotes 4 months ago

The user checked iron, ferritin, B12, zinc, testosterone, DHT, and estrogens to understand hair loss causes and the effects of dutasteride. They also noted increased heart rate and paleness with oral minoxidil.

community Oral minoxidil: dosing and frequency

in Treatment 3 upvotes 4 months ago

A user is considering taking oral minoxidil 3mg every other day or thrice a week to minimize side effects and save money. They seek opinions on this dosing strategy.

community oral minoxidil collagen contradiction

in Minoxidil 13 upvotes 5 months ago

The conversation discusses concerns about oral minoxidil potentially aging the face by affecting collagen, questioning its systemic effects. The user has successfully used topical minoxidil for years and is hesitant to switch to oral minoxidil.

community Countering oral minoxidil side effects by taking collagen supplements?

in Minoxidil 16 upvotes 5 months ago

Oral minoxidil may deplete collagen, potentially causing skin aging. Users discuss whether taking collagen supplements can counteract this effect.

community Oral minoxidil 2.5mg + Oral Finasteride 0.25mg MWF + 1.5mm microneedling weekly - 2 Months Progress

in Progress Pictures 19 upvotes 6 months ago

The user shared progress pictures after using oral minoxidil 2.5mg, oral finasteride 0.25mg three times a week, and weekly 1.5mm microneedling for two months. They reported positive results in hair growth.

community Oral dutasteride vs topical efficacy

in Finasteride/Dutasteride 60 upvotes 6 months ago

The user switched from topical minoxidil/dutasteride to oral dutasteride, resulting in hair loss. They resumed topical treatment without regrowth and are considering switching to finasteride due to poor results with oral dutasteride.

community Oral Fin/Topical Min and derma rolling over a year progress. Feeling more confident (: 29m

in Progress Pictures 214 upvotes 6 months ago

The conversation is about a 29-year-old man's progress with hair loss treatment over a year using oral finasteride, topical minoxidil, and dermarolling, which has led to improved hair coverage and increased confidence. Users are encouraging and asking about the timeline of noticeable improvements.