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GlossaryOral Mucosa (oral epithelium)

moist tissue lining the inside of the mouth

The oral mucosa, also known as the oral lining or mouth lining, is the moist tissue that lines the inside of the mouth. It consists of a stratified squamous epithelium layer and an underlying connective tissue called the lamina propria. This tissue serves as a barrier to protect against mechanical damage, pathogens, and toxins, and plays a role in sensation and secretion.

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community Finasteride only reduces scalp DHT by ~40%. Why does it work?

in Finasteride/Dutasteride 37 upvotes 1 year ago

How Finasteride and Dutasteride help reduce hair loss by reducing the amount of DHT in scalp areas, as well as discussing factors such as sensitivity to DHT, 5α-reductase expression in different parts of the hair follicle, and scalp tension.

community Long term finasteride users; Did you notice any improvement after 2 years?

in Finasteride/Dutasteride 14 upvotes 1 year ago

Long term Finasteride users and whether or not they have noticed improvements after two years of use, with other treatments such as Minoxidil and dermarolling also discussed. Some replies suggest that improvement is possible even beyond the two year mark while others caution against believing studies backed by the Post-Finasteride Foundation.

community A meta analysis of 18 popular hair loss treatments. An 2022 guide on efficacy. From finasteride and minoxidil to caffeine shampoo, saw palmetto and biotin. 96 Scientific References included.

in Research/Science 101 upvotes 2 years ago

Most hair loss treatments are ineffective; only finasteride, dutasteride, and minoxidil show effectiveness.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Is it possible for androgenic alopecia to begin at early adolescent years?

in Chat 70 upvotes 1 year ago

Hair loss can begin in early adolescence and cause mental anguish. Treatments mentioned include eating cruciferous vegetables, engaging in physical activity, and maintaining scalp hygiene.

community This is the best time in human history to be fighting hair loss

in Treatment 193 upvotes 2 years ago

This conversation discusses the advancements in treatments for hair loss, including finasteride, dutasteride, minoxidil and new promising treatments such as pyrilutamide and verteporfin. Other treatments discussed were taking minoxidil orally, tretinoin to turn non-responders into responders and microneedling to further boost growth.

community Comprehensive Microneedling Guide

in Microneedling 292 upvotes 2 years ago

Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 449 upvotes 3 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

community Evidenced Based Meta-Analyses and Systemic Reviews of Androgenic Alopecia and Treatments

in Research/Science 15 upvotes 4 years ago

Evidence-based treatments for androgenic alopecia, such as minoxidil, finasteride, low-level laser light therapy, dutasteride, platelet-rich plasma, and topical ketoconazole. It discusses the efficacy, safety, and mechanism of action of these treatments, as well as future developments in understanding this polygenic condition.

community Why a lot of people seems to hate on topical fin even though it suppresses more scalp dht?

in Chat 20 upvotes 1 month ago

Topical finasteride may reduce more scalp DHT but is seen as inconsistent and messy compared to oral finasteride. Users report mixed results with both forms, with some preferring oral for its convenience and consistent dosing, while others find topical effective but harder to apply.

community It works. About a 1 year transformation.

in Progress Pictures 613 upvotes 1 year ago

A user's experience with hair loss treatments, specifically Minoxidil and finasteride, which they have used without side effects for a year. Other users shared their experiences and advice about potential side effects and supplements to help.

community Oral minoxidil 2.5 mg since end of July 2024 till November 2024

in Is this regrowth? 464 upvotes 1 week ago

Oral minoxidil has shown positive results for hair regrowth, but concerns about its side effects, such as heart issues, are noted. Adding a DHT blocker like finasteride is recommended for better and more lasting results.

community Oral minoxidil or topical with tretinoin?

in Minoxidil 5 upvotes 2 weeks ago

The conversation discusses the effectiveness of oral minoxidil versus topical minoxidil with tretinoin for hair regrowth, with some users suggesting oral minoxidil might be more effective for non-responders to topical treatments. Concerns about side effects and the role of enzymes in activating minoxidil are also mentioned.

community Is microneedling + minoxidil better than oral minoxidil

in Chat 29 upvotes 3 weeks ago

Oral minoxidil is considered more effective for hair regrowth than topical minoxidil, but it carries higher risks. Combining microneedling with topical minoxidil can enhance absorption, but oral minoxidil with microneedling shows significant results.

community Oral min and ru 🙏let’s hope these go terminal

in Is this regrowth? 1 month ago

The conversation discusses hair regrowth using oral minoxidil and RU58841, with visible baby hairs appearing after two months. One user questions the choice of RU58841 over finasteride.

community Oral min vs topical comparison

in Treatment 10 upvotes 1 month ago

Oral minoxidil is claimed to be more effective and easier to use than topical minoxidil, with a 100% response rate, but it may cause unwanted body hair growth and has potential heart-related side effects. Topical minoxidil is less effective for many due to enzyme limitations, can cause scalp issues, and is more challenging to apply, but it avoids systemic side effects.

community What's "wrong" with oral minoxidil, exactly?

in Minoxidil 173 upvotes 1 month ago

Oral minoxidil can boost hair growth but may cause side effects like heart palpitations and increased body hair. Many prefer topical minoxidil due to fewer side effects.

community Oral Biotin and Topical Minoxidil have a synergy effect in increasing hair growth, the study was only done in healthy subjects and it was only 14 days but it does prove that biotin can play a significant role as an adjunct treatment.

in Research/Science 170 upvotes 1 month ago

Oral biotin combined with topical minoxidil may increase hair growth rate, though the study was limited to healthy subjects and did not measure hair density. Some users report personal benefits from biotin, such as faster nail growth and healthier hair, but concerns about acne and study quality were also mentioned.

community Oral minoxidyl and topical minoxidyl

in Minoxidil 2 upvotes 1 month ago

Using both oral and topical minoxidil is likely safe, but be cautious of increased systemic absorption. The best tretinoin dosage to enhance minoxidil effectiveness is not specified.

community Oral 0.5mg dut + 2mg min 4 months. Topical 5% min since february.

in Is this regrowth? 41 upvotes 1 month ago

The user has been using oral dutasteride 0.5mg, oral minoxidil 2mg, and topical minoxidil 5% for hair regrowth, along with microneedling. They have seen significant hair coverage improvement and are considering additional supplements for better results.

community Is Tretinoin gel useful with Oral Minoxidal?

in Minoxidil 7 upvotes 1 month ago

Oral minoxidil and finasteride are the main treatments for hair loss, with microneedling as an additional method. Tretinoin gel is not necessary with oral minoxidil but can be used for skincare.

community Theory As To Why Oral Minoxidil Might Be Helpful To People Compared To Topical Minoxidil

in Minoxidil 8 upvotes 1 month ago

Oral minoxidil may be more effective than topical due to uniform distribution and systemic activation, but can cause side effects like puffiness. Adding tretinoin to topical minoxidil can enhance its effectiveness by aiding conversion to its active form.

community Failure with 5mg oral minoxidil, looking for experiences of people who used topical with glycerin as a vehicle.

in Minoxidil 6 upvotes 1 month ago

Oral minoxidil was ineffective for OP, causing hair loss and unwanted body hair, while topical minoxidil showed significant regrowth. OP is switching to topical minoxidil with glycerin due to scalp issues with propylene glycol.

community Oral Minoxidil Eyelashes Are Insane

in Minoxidil 288 upvotes 2 months ago

Oral minoxidil can significantly increase eyelash length and thickness. Users report mixed results on hair growth, with some experiencing increased body hair.

community Oral Minoxidil worse hair after 1 year

in Progress Pictures 41 upvotes 2 months ago

The user switched from topical to oral Minoxidil and Finasteride but saw no improvement after a year, with hair appearing thinner. They recently switched to Dutasteride, hoping for better results.

community Oral minoxidil 6 months update. Have I beaten the reaper yet?

in Satire 680 upvotes 3 months ago

The post and conversation discuss a user's 6-month update on using oral minoxidil for hair loss, with humorous and satirical replies. Some comments suggest discontinuing due to side effects.

community Oral or topical finasteride? .

in Chat 12 upvotes 3 months ago

A user is deciding between oral and topical finasteride for hair loss, noting oral finasteride's ease of use but broader effects. Another user simply recommends oral finasteride.

community Oral vs Topical Finasteride for Trans Women

in Transgender 3 months ago

A user is using a Finoxidil topical spray and is curious if oral Finasteride would be more effective, considering they are already on a DHT blocker called Cyproterone. They are concerned about the potential impact of oral Finasteride on their transition.

community Oral min and Isotretinoin (accutane) to respond

in Chat 3 months ago

Oral minoxidil combined with isotretinoin may improve hair loss treatment effectiveness. Tretinoin is known to increase the absorption of topical minoxidil.

community Oral Minoxidil in Europe (10 mg)

in Minoxidil 9 upvotes 3 months ago

The user is seeking oral Minoxidil in Europe due to issues with topical Minoxidil causing dandruff and dry scalp. They have started using oral Finasteride and are considering Ketoconazole shampoo.