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The conversation is about using distilled water as a solvent for topical finasteride to reduce systemic absorption. The user is considering avoiding ethanol and propylene glycol to achieve this.

The conversation discusses concerns about the solubility and stability of topical finasteride (Fynzur) when diluted with ethanol and distilled water, without propylene glycol. The user is worried about the even distribution of finasteride in the solution.

The conversation is about the use of emulsifiers in a propylene glycol and ethanol solvent for minoxidil formulations. Emulsifiers are typically around 1-3% of the total vehicle and help disperse the contents.

The conversation discusses the best ethanol and propylene glycol ratio for homemade topical finasteride, with a focus on absorption and drying issues. The user shares their experience using a 50% propylene glycol, 30% ethanol, and 20% water solution, and considers adjusting the ethanol content for better results.

Topical finasteride may have higher systemic absorption and lower efficacy when using a Propylene Glycol/Ethanol formulation compared to the hydroxypropyl chitosan (HPCH) formulation. The safety profile of topical finasteride relies heavily on the HPCH formulation, and using standard solutions might lead to different pharmacokinetics.

The conversation discusses adjusting the isopropyl alcohol, propylene glycol, and water ratios in a topical finasteride solution for better scalp comfort and less dandruff. The user considers using 20ml IPA, 25ml PG, and 15ml water in a 60ml bottle, moving away from mixing finasteride with topical minoxidil.

The conversation is about formulating a solvent for topical finasteride without using propylene glycol. Suggestions include using ethanol, glycerin, and distilled water in various ratios, with some discussion on the use of emulsifiers.

The conversation discusses the best ratio of propylene glycol in Minoxidil, with a mention of 20% being used in tests, while Kirkland's version seems more oily. Users share experiences with Minoxidil, Finasteride, and RU58841 for hair loss treatment.

The conversation is about recreating a solvent for hair loss treatments, discussing the use of water, ethanol, glycerin, dimethyl isosorbide, and polysorbate 20. The effectiveness of these solvents depends on the solubility of the substances being dissolved.

The conversation is about whether finasteride can be mixed with just water for a topical solution and if Isopropyl Alcohol and Propylene Glycol are necessary for effectiveness and faster drying. The user is seeking advice on the formulation of topical finasteride.

A user is discussing making a DIY topical finasteride solution using ingredients like water, alcohol, propylene glycol, ethanol, and glycerin, and is concerned about the stability of the mixture. Other users suggest that the solution will work and discuss the importance of propylene glycol for drug dissolution and factors like temperature and light affecting finasteride stability.

The user is trying to dilute a 0.25% finasteride spray but is experiencing hair issues with a substitute alcohol mixture containing propylene glycol. They are advised to use a mixture of 20% propylene glycol, 65% alcohol, and 15% purified water, but cannot use minoxidil due to adverse effects.

The conversation is about dissolving Dutasteride in propylene glycol for hair loss treatment, with concerns about solubility at 0°C. It suggests using a 0.025% concentration for topical application.

RU-58841 does not dissolve well in common Minoxidil solutions due to water content, requiring a 70/30 ethanol/propylene glycol mix. Users report using separate solutions for RU-58841 and finasteride/Minoxidil for better results.

Homemade topical finasteride solutions are discussed, with one user using 30% ethanol, 50% propylene glycol, and 20% water. Alternatives like dissolving finasteride pills in minoxidil and using stemoxydine are also mentioned.

The user has been mixing finasteride with stemoxydine for hair loss and is considering switching to a less expensive product with a different ingredient list. They are questioning if the new product's higher water content compared to alcohol will affect the finasteride's solubility.

The conversation is about the effectiveness of Minoxidil formulations with different alcohol and propylene glycol (pg) ratios. The user finds that a formulation with 20% pg and 80% ethanol dries faster but is concerned about absorption time.

A user made a 60ml bottle of topical finasteride and noticed faster evaporation due to ethanol, affecting concentration. Suggestions included adjusting the finasteride concentration and application method to minimize ethanol evaporation.

The conversation discusses using glycerin instead of propylene glycol as a vehicle for topical finasteride, with concerns about glycerin causing skin issues. A suggestion is made to use a mixture of 60% ethanol, 20% glycerin, and 20% water to mitigate these concerns.

The user mixes their own RU58841 solution and found that increasing the ethanol content improved absorption and reduced scalp itching. A study on minoxidil showed that penetration increased with higher ethanol concentrations, reaching maximum penetration at 90% ethanol.

Kirkland Minoxidil typically contains 50-60% propylene glycol. Users suggest adjusting the percentage for sensitive skin.

The conversation discusses the pros and cons of using propylene glycol versus ethyl alcohol in topical solutions for finasteride and minoxidil. It questions why propylene glycol is commonly used and whether ethyl alcohol might be a better option.

The user wants to make a topical finasteride solution using wound cleanser with 70% IPA and add 40% propylene glycol due to headaches from minoxidil. They seek advice on using the wound cleanser and recommendations for pharmaceutical/cosmetic grade IPA in India.