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GlossaryNonsteroidal Antiandrogens (NSAA)

medications that block male hormones without activating their receptors

Nonsteroidal Antiandrogens (NSAA) are medications that block the action of androgens (male hormones like testosterone) by binding to androgen receptors without activating them. They are commonly used in the treatment of conditions like prostate cancer and androgenic alopecia (hair loss) by preventing androgens from stimulating the growth of cancer cells or hair follicles.

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Tracking 2 products like 259 Pyrilutamide (KX-826) Solution – 30ml 5mg/ml and 262 Pyrilutamide KX-826 Powder – 500mg from by companies like Anageninc. View all 2 products »

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community I'm a tressless woman who's ready to call it quits.

Tresslesswoman in Female 11 upvotes 5 years ago

A woman who is considering giving up on her hair loss journey after trying minoxidil and spironolactone, but other posters offer words of encouragement and suggest the use of wigs.

community Why are there no FDA approved NSAA's yet?

Suspicious_City4587 in Research/Science 8 months ago

The conversation discusses why there are no FDA-approved NSAAs like RU58841 on the market, despite their potential superiority to 5AR inhibitors like finasteride. It explores the effectiveness of treatments like Minoxidil, finasteride, and RU58841 for hair loss.

community RU-58841 Experience (15mg daily dissolved in stemoxydine)

LasDrogasThrowaway in Treatment 14 upvotes 3 years ago

User experienced reduced hair loss with 15mg RU in Serioxyl but had concerning chest pain. Others suggested consulting a doctor or lowering the dose.

community Does anyone here who is on ru58841 have lab results of their DHT levels?

GamingGirlsb in Treatment 7 upvotes 6 months ago

The user discussed switching from RU58841 with Minoxidil to Finasteride due to cost, noting better physical feelings and hair growth with RU58841. They are considering returning to RU58841 and checking DHT levels after a month.

community The hardest hair protocol ever!

onajLikZnasGa in Research/Science 10 upvotes 2 years ago

The user is using RU58841, finasteride, dutasteride, and minoxidil to slow down aggressive hair loss but is still experiencing hair shedding due to high testosterone levels. They plan to use ostarine to lower testosterone and prevent hair loss while maintaining muscle mass, and will continue using the other treatments.

community Anyone wanna try and interview the developers of RU?

Lysander1999 in Research/Science 84 upvotes 3 years ago

The conversation discusses arranging an interview with the developers of RU58841 to clarify its safety and reasons for halted research, with some users expressing concerns about potential risks and others citing financial reasons for the discontinuation of studies. Specific treatments mentioned include RU58841, minoxidil, and finasteride.

community First people receive Pyrilutamide March 19th 2022!

thankseveryone4life in Treatment 126 upvotes 2 years ago

First people receive Pyrilutamide on March 19th, 2022 for hair loss treatment. Users discuss obtaining the drug, its patent, and potential group buys.

community RU-58841 Lung Disease Possibility | Chest pain, "heart issues", etc

noeyys in Treatment 24 upvotes 11 months ago

Some users of RU-58841 report cardiovascular symptoms like heart palpitations and chest tightness, which may be linked to its metabolites causing lung disease. The safety of RU-58841 is uncertain due to lack of long-term data and concerns about product purity, especially from gray market sources.

community Would Fluridil and Alfatradiol work effectively in conjunction with each other?

DoubleAmbassador in Treatment 7 upvotes 4 years ago

Whether using both Fluridil and Alfatradiol together could be more effective than either one alone as a hair loss treatment, given their different mechanisms of action.

community For those on TRT and suffer from a more aggressive type of (AGA) hairloss, what are your hair safe protocols?

BaldyBro in Chat 6 upvotes 2 years ago

People on testosterone replacement therapy (TRT) with aggressive androgenetic alopecia (AGA) discuss using Dutasteride or Finasteride, sometimes combined with topical treatments like RU58841 or CB-03-01 (Breezula), to prevent hair loss. Concerns about side effects and costs of certain treatments are mentioned, with one individual sharing their experience of slowed hair loss using Finasteride alone.

community Fluridil downregulates androgen receptor expression?

IllIssue229 in Research/Science 1 upvotes 1 year ago

Fluridil may decrease the number of androgen receptors in hair follicles by up to 95%. This suggests a different action mechanism from other non-steroidal antiandrogens like RU58841, indicating they might be used together.

community Been on Min and Fin for Years and I am Devastated.

Guyman567 in Treatment 64 upvotes 2 years ago

Guyman567 has been using oral finasteride and topical minoxidil for years but continues to experience hair loss and thinning, which has affected his confidence. He has tried various treatments including topical finasteride, microneedling, and vitamins, and is considering a hair transplant but is concerned about ongoing hair loss.

community No side effects on pyrilutamide / KX-826 so far

TopBack56 in Research/Science 207 upvotes 3 years ago

User TopBack56 and friends tried pyrilutamide (KX-826) for hair loss without experiencing negative side effects. They observed fine vellus hairs but no thick hair growth yet, and plan to add GT20029 to their regime after safety trials.

community 2 years on dut (.5mg three times per week) 1 and a half on RU 5% (once a day)

ThrowRA42677 in Progress Pictures 259 upvotes 1 month ago

The user experienced significant hair regrowth using dutasteride (0.5 mg three times a week) and RU58841 (5% once a day), with no side effects reported from RU58841. They are considering increasing the RU58841 dose or adding minoxidil for further improvement.

community CB-03-01 supposed hair loss cure

Intrepid-Soil817 in Treatment 9 upvotes 3 years ago

The conversation discusses why CB-03-01, a potential hair loss treatment, isn't widely discussed despite evidence of its effectiveness and safety. Some users mention other treatments like melatonin, procianidin b2, and RU58841, debating their effectiveness and safety.

community Insane dutasteride shed 4 months after switching.

NotaVortex in Finasteride/Dutasteride 115 upvotes 1 year ago

The post and conversation are about a user's experience with hair loss treatments, specifically switching from finasteride to dutasteride. The user experienced significant hair shedding after the switch, with others suggesting patience, noting similar experiences, or questioning the user's decision and medical consultation.

community Hair much worse after 6 months?

Copy_Successful in Progress Pictures 230 upvotes 1 year ago

A user experienced significant hair loss after 6 months of using 0.5mg finasteride daily. Suggestions from others included trying Dutasteride and Minoxidil, getting professional help from a dermatologist, and addressing high iron levels that could be contributing to the hair loss.

community Binding affinity of pyrilutamide!

alexffy66433 in Update 171 upvotes 2 years ago

Pyrilutamide, a nonsteroidal antiandrogen drug under development for the potential treatment of androgenic alopecia. The conversation discusses its binding affinity to the androgen receptor and the timeline for possible availability after trials are completed in the United States and China.

community 1 year on fin. No results. I give up.

reeds1164 in Finasteride/Dutasteride 43 upvotes 2 years ago

A user who has been taking finasteride, minoxidil, and microneedling for one year with no results, and the replies discuss other treatments, including dutasteride, which is feared due to potential side effects.

community Pyrilutamide six months update{ New Progress Pics}

Ok-Temperature-4359 in Progress Pictures 318 upvotes 1 year ago

A user shared a six-month update on hair improvement using Pyrilutamide and Minoxidil, noting significant hair regrowth and strength. Some participants questioned the legitimacy of the results and the source of Pyrilutamide.