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Glossary Nanoemulgel

topical formulation combining nanoemulsion and gel for enhanced delivery

A nanoemulgel is a type of topical formulation that combines the properties of a nanoemulsion and a gel. Nanoemulsions are tiny droplets of one liquid dispersed in another, often used to enhance the delivery of active ingredients through the skin. When these nanoemulsions are incorporated into a gel, the resulting nanoemulgel can improve the stability and penetration of therapeutic compounds, making it particularly useful in treatments for conditions like alopecia or other skin-related issues.

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community Minoxidil Skin Delivery from Nanoemulsion Formulations Containing Eucalyptol or Oleic Acid: Enhanced Diffusivity and Follicular Targeting

4 upvotes 1 year ago

Minoxidil can be effectively delivered through nanoemulsions containing eucalyptol or oleic acid, enhancing its diffusivity and targeting hair follicles. This contradicts the advice against mixing minoxidil with oils in topical formulations.

community carriers other than PG for ru58841 ? Help !!

5 upvotes 1 year ago

The user is seeking alternatives to propylene glycol and glycerin for mixing with RU58841 due to allergies and greasiness. Suggestions include reducing glycerin and considering stemoxydine as a solvent.

community Switching RU vehicle due to scalp irritation – anyone tried low-EtOH + squalane / emu oil?

in Treatment 2 upvotes 9 months ago

The user is experiencing scalp irritation from using RU58841 with a 70% ethanol and 30% propylene glycol vehicle and is considering switching to a less irritating vehicle, such as 30% ethanol with 70% squalane or emu oil. They are seeking feedback on the effectiveness and irritation levels of these alternative carriers.

community For pg free minoxidil, why not use propanediol instead of glycerin?

2 upvotes 4 months ago

The conversation discusses using propanediol as an alternative to glycerin in PG-free minoxidil for better absorption. The user also plans to try nanoxidil, which may absorb more easily due to its smaller molecule size.

community Where do you all get your pg+e

5 upvotes 3 years ago

The conversation discusses using stemoxydine as a carrier for RU58841 and the search for affordable, premixed PG+E. Minoxidil is considered as an alternative, but simplicity is preferred.

community Why don't do it yourself topical solutions not talk about ethosomes as delivery mechanism?

4 upvotes 10 months ago

Ethosomes are suggested as an effective delivery method for topical finasteride solutions, requiring the addition of a phospholipid like soya lecithins. The user questions why do-it-yourself solutions don't commonly use ethosomes despite their potential benefits.

community Selling KY19382 powder a novel activator of Wnt/β-catenin signaling

4 years ago

The conversation is about selling KY19382 powder, a novel activator of Wnt/β-catenin signaling, and Kolliphor EL liquid for vehicle formulation. The seller offers worldwide shipping.

community Making PG free solution at home

1 upvotes 2 years ago

A user wants to make a solution for RU58841 and finasteride powder using only glycerin and asks if ethanol is necessary. They are seeking advice on whether glycerin alone is sufficient.

community Anyone try Ell-Cranell or Eucapil?

4 upvotes 5 years ago

Ell-Cranell and Eucapil are discussed as hair loss treatments, with Ell-Cranell being a weak estrogen and DHT inhibitor that may reduce hair loss without systemic side effects. Alfatradiol is the active ingredient in these products.

community Musely s Exosome formulation looks interesting

14 upvotes 1 year ago

Exosomes, cetirizine, melatonin, latanoprost, and caffeine are discussed as potential hair loss treatments. There is skepticism about the effectiveness of exosomes, especially in topical form, but some users report positive results.

community Keratin microspheres - breakthrough

14 upvotes 2 years ago

A gel of keratin microspheres promotes hair follicle growth, showing similar effectiveness to minoxidil in mice. The treatment activates hair growth pathways and reduces inflammation, with potential applications in drug delivery for hair-related disorders.

community Anyone try RU58841 from this brand? truth진실

4 upvotes 1 year ago

The conversation discusses skepticism about the effectiveness and formulation of a $10 RU58841 gel from a Korean brand, questioning if ethanol is used to hold the active compounds. Concerns are raised about the feasibility of selling it at such a low price.

community ASCEplus HRLV Exosomes with microneedling

1 upvotes 2 years ago

The discussion is about using ASCEplus HRLB exosomes for hair loss treatment, which combines 10 billion exosomes with growth factors, nutrients, biotin, and copper tripeptide. The treatment is expensive and typically administered via scalp injections, but in Europe, it's done with microneedling.

community Combining Microneedling with LLLT

14 upvotes 1 year ago

Combining microneedling with Low Level Laser Therapy (LLLT) for hair growth, with discussions on device legitimacy and effectiveness. Alternatives like PEMF and the use of oral and topical treatments such as dutasteride, minoxidil, and finasteride are also considered.

community Minokem-N cotains hydrocortisone?

2 upvotes 1 year ago

Minokem-N's composition is unclear, with concerns about unlisted hydrocortisone. Users discuss alternatives like AloATM, which lacks soothing agents, and the challenges of verifying ingredients.

community Hair Regrowth by Transdermal Dissolvable Microneedles Loaded with Rapamycin and Epigallocatechin Gallate Nanoparticles - PubMed

15 upvotes 4 years ago

The conversation discusses hair regrowth using dissolvable microneedles loaded with rapamycin and epigallocatechin gallate nanoparticles. Specific treatments mentioned include Minoxidil, finasteride, and RU58841.

community Why are we using 1.5mm for microneedling? Evidence says we don't need to.

39 upvotes 4 months ago

Shorter microneedle lengths, like 0.5mm, may be more effective and safer for hair regrowth than longer ones, such as 1.5mm, which can cause more pain and risk. Users report success with various regimens, including minoxidil, finasteride, and other topicals, alongside microneedling.

community Anyone tried Regenera stem cells, or exosomes? Anyone with FPHL too or just in general?

1 upvotes 1 year ago

The conversation discusses hair loss treatments, specifically Regenera stem cells and exosomes from 'Cellgenic' umbilical cord donors. The user has been using topical minoxidil 5% and 0.001% estradiol for a year without seeing effects, and another user mentions the importance of microneedling.

community Topical finasteride in liposomal formulation

6 upvotes 6 years ago

Topical finasteride in a liposomal formulation reduces systemic absorption compared to ethanol solutions. The user is seeking sources for such products, noting that popular options like morr-f are not liposomal.

community RU and cetosomal minoxidil topical

1 upvotes 7 months ago

Mixing RU58841 with cetosomal minoxidil is discussed due to scalp irritation from ethanol PG vehicles. A mixture of the two turned bright pink when left to dry.

community Been Microneedling for 4 weeks. Positive results, however, quite slow.

1 upvotes 6 years ago

The user has been microneedling for 4 weeks and using treatments like minoxidil and eclipta alba oil, seeing positive but slow results. They are considering peppermint oil as a potentially more effective alternative to minoxidil.

community Microneedling at .25 everyday before applying Min

in Minoxidil 26 upvotes 1 year ago

Daily microneedling at 0.25mm before applying minoxidil is debated, with some suggesting weekly microneedling is safer and more effective. Concerns include potential skin damage and systemic absorption, while alternatives like tretinoin are considered safer for enhancing minoxidil absorption.

community Making topical finasteride with ethanol + propylene glycol vs mixing it with topical minoxidil

2 upvotes 9 months ago

The conversation discusses two methods for making topical finasteride: using ethanol and propylene glycol or mixing it with topical minoxidil. The focus is on solubility and absorption, with a suggestion to crush pills finely and possibly mix with minoxidil at a slightly elevated temperature.

community Replacing Microneedling with Lice?

in Chat 70 upvotes 1 year ago

Using lice as an alternative to microneedling for hair loss treatment, with concerns about effectiveness and practicality. Some users humorously suggest genetically altering lice to produce beneficial compounds.

community Anyone have an alternative solvent for pyrilutamide??

in Product 2 upvotes 2 years ago

The user is seeking an alternative solvent for pyrilutamide due to skin irritation from ethanol and propylene glycol. They experienced similar issues with topical minoxidil.

community Do exosomes actually work to regrow hair?

9 upvotes 1 year ago

Microneedling with exosomes is being considered for hair regrowth, but concerns exist about their effectiveness and safety, especially since exosomes degrade quickly and lack FDA approval. The user is seeking alternatives for non-responders to minoxidil and dutasteride, as exosomes may not provide additional benefits.

community PG free Ru58841 solvent in the UK

2 upvotes 2 weeks ago

The conversation discusses finding a PG-free solvent for dissolving RU58841 in the UK, with glycerin suggested as a potential alternative. Water is also mentioned as a possible option.

community topical exosomes - experimenting

1 upvotes 6 months ago

The conversation is about experimenting with topical exosomes for hair loss treatment, alongside microneedling, Happy Head's gel-like topical, and Ordinary's hair serum. The user also mentions the availability of treatments like latanoprost and Redensyl.

community I tried mixing 3 grams RU58841 into 60ml minoxidil 5% solution and shook for 5 minutes and I can still see tiny crystals floating around like a snow globe when I shine a torch in the bottle

4 upvotes 5 months ago

OP mixed RU58841 with minoxidil and initially saw crystals, but realized they were bubbles. They asked for advice on application frequency for a 5% solution.

community Anyone on topical fin using glycerin instead of PG as humectant?

1 upvotes 7 months ago

Switching to a DIY topical finasteride solution using ethanol, glycerin, and distilled water instead of propylene glycol for a gentler application. Users report positive results with both DIY solutions and a low PG minoxidil and finasteride product from India.