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GlossaryMultiphoton Microscopy (MPM)

uses multiple photons for deep, detailed tissue imaging

Multiphoton Microscopy (MPM) is an advanced imaging technique that allows scientists to view living tissues at a cellular level with high resolution. Unlike traditional fluorescence microscopy, MPM uses multiple photons of lower energy to excite fluorescent dyes, reducing photodamage and allowing deeper tissue penetration. This makes it particularly useful for studying complex biological structures, such as hair follicles and skin layers, in their natural state.

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community If RU58841 is such an effective anti androgen

in Research/Science 46 upvotes 11 months ago

RU58841 is discussed as a topical anti-androgen for hair loss, but its effectiveness and safety are not well-documented, leading to mixed opinions and experiences among users. Some combine it with finasteride, but concerns about side effects and lack of FDA approval limit its popularity.

community Ru58841 powder storage - Freezer or room temperature?

in Research/Science 6 upvotes 1 week ago

RU58841 powder storage, with differing opinions on whether to store it in the freezer or at room temperature. One user prefers the freezer, while a company suggests room temperature.

community Anyone else buy their Ru58841 direct from a chinese supplier?

in Treatment 1 upvotes 3 months ago

The conversation discusses buying RU58841 directly from a Chinese supplier for cost savings. It mentions that companies like Anageninc and Actifolic do the same.

community 6 months of Dutasteride & topical minoxidil before and after

in Progress Pictures 21 upvotes 1 year ago

The user shared their 6-month hair regrowth progress using 0.5mg Dutasteride daily, 1ml topical Minoxidil twice daily, and recently added RU58841, excluding results from a hair transplant area. They are hopeful for further improvement after continued use of all three treatments.

community Would RU58841 work on a test cycle?

in Technology 1 upvotes 3 months ago

OP experienced side effects from finasteride and is considering using RU58841 to prevent hair loss during a testosterone cycle. They have also used minoxidil, Nizoral, alfatradiol, and fluridil successfully.

community How did you get over the fear mongering of Fin/Dut?

in Finasteride/Dutasteride 62 upvotes 4 months ago

The conversation is about overcoming fear of finasteride/dutasteride for hair loss treatment. Users suggest starting with a small supply, noting side effects are rare and reversible, and emphasize personal comfort and confidence.

community Did pre-tests before starting finasteride, turns out I have abnormally high estrogen

in Finasteride/Dutasteride 1 upvotes 4 months ago

A 23-year-old with high estrogen levels is considering starting finasteride for hair loss and plans to use a low dose topical treatment while also seeking to lower estrogen levels. They will consult an endocrinologist for further guidance.

community ‘Long term use of fin/dut may be associated with health risks including fatty liver disease, insulin resistance, type 2 diabetes, dry eye disease and potential kidney disease.’

in Research/Science 22 upvotes 5 months ago

Long-term use of finasteride and dutasteride may be linked to health risks like fatty liver disease, insulin resistance, type 2 diabetes, dry eye disease, and potential kidney disease. Some users believe the risks are low and the medications are generally safe.

community Is this broscience? From More Plates, More Dates

in Research/Science 21 upvotes 9 months ago

The conversation discusses whether finasteride's reduction of DHT and increase in scalp testosterone contribute to hair follicle miniaturization. Some participants argue testosterone does not cause miniaturization, while others suggest that even with reduced DHT, other androgens like testosterone may still contribute to hair loss.

community Spironolactone or bicalutamide prescription

in Treatment 4 upvotes 1 year ago

The conversation is about someone seeking a doctor in the EU who prescribes spironolactone or bicalutamide for female pattern hair loss, as they are having difficulty finding treatment options beyond Minoxidil in Austria. They are asking for recommendations and are open to direct messages for assistance.

community Testosterone and hair loss seeming irrelevance

in Research/Science 81 upvotes 1 year ago

The conversation is about the role of testosterone in hair loss and the effectiveness of different treatments. The conclusion is that DHT is the main culprit for hair loss, and finasteride has been proven to work long-term in maintaining and regrowing hair. Testosterone may have a minor effect, but it is not the primary cause of hair loss.

community Just started pyrilutamide today, going to update this post every month.

in Treatment 48 upvotes 2 years ago

A user beginning a treatment of pyrilutamide for hair loss, which they plan on updating progress on every month.

community 15 months on the Big 3! My journey so far…

in Progress Pictures 162 upvotes 2 years ago

A user's progress after 15 months of using the "Big 3" treatments for hair loss (finasteride, minoxidil and micro needling) as well as Nizerol 2%. The post encourages others to seek out available information on hair loss treatment and reassures them that if it doesn't work, it is only hair.

community My Testosterone results before and after Finasteride

in Update 146 upvotes 3 years ago

Finasteride significantly increased testosterone levels for the user, with no major side effects except watery semen, which was resolved with zinc supplements. The user's hairline stopped receding and slightly improved.

community Castor Oil - Yay or Nay?

in Product 10 upvotes 3 years ago

The conversation discusses the potential benefits of castor oil for hair thickening, with one user noting it may increase prostaglandin E2 and decrease PGD2. The original poster plans to take 1-2ml orally daily.

community Can someone explain the science behind why Finasteride doesn't stop you from losing regrown hairs from minoxidil?

in Minoxidil 100 upvotes 3 weeks ago

Finasteride prevents further hair loss by blocking DHT, while minoxidil stimulates hair growth by prolonging the active phase of hair follicles. Stopping minoxidil can lead to loss of regrown hair because finasteride does not address the same growth mechanism.

community What Private blood test should I take?

in Finasteride/Dutasteride 7 upvotes 4 months ago

A user in the UK seeks advice on blood tests before starting Finasteride and Minoxidil for hair loss. Recommended tests include thyroid function, hormone levels, liver and kidney function, and vitamin and mineral levels.

community Kintor stealing pictures from a hair transplant clinic to promote their failed product (KX826, Pyrilutamide)

in Product 314 upvotes 4 months ago

Kintor is accused of using fake pictures to promote their product, Pyrilutamide (KX826), which failed Phase 3 trials. Users express disappointment and note similar false advertising has occurred with finasteride and minoxidil.

community Is topical finasteride as effective as oral finasteride?

in Finasteride/Dutasteride 6 upvotes 5 months ago

Topical finasteride is almost as effective as oral finasteride with fewer side effects. Users are considering between oral and topical finasteride for hair loss treatment.

community Wait, this is actually working?! Feb - Jun

in Is this regrowth? 116 upvotes 5 months ago

The user experienced hair regrowth after 4 months of using topical finasteride and minoxidil, 2 weeks of dermatolling, and possibly tretinoin. They also noted improved mental health and reduced weight training.

community Progress August>Dec>today Fin 1mg, Topical Min

in Progress Pictures 104 upvotes 6 months ago

User shared progress pictures of hair density improvement using 1mg finasteride and topical minoxidil, but expressed concern about recent hairline miniaturization and treatment effectiveness. Another user complimented the results and inquired about initial shedding.

community Anyone using oral castor oil in their stack?

in Treatment 3 upvotes 6 months ago

The conversation discusses using oral castor oil as a hair growth stimulant for beard and scalp hair. One user questions its use, noting castor oil is typically a laxative in the Philippines.

community Tropical growth stimulants other than minoxidil

in Treatment 11 upvotes 6 months ago

The conversation discusses alternative hair growth treatments to minoxidil, including Stemoxydine, Tretinoin, adenosine, Baicalin, castor oil, Latanoprost/bimatoprost, and Redensyl. Users share their experiences and opinions on the efficacy of these treatments.

community Why isn’t oral minoxidil enough for me?

in Minoxidil 7 upvotes 9 months ago

A user takes 5mg oral minoxidil, oral dutasteride, topical tretinoin, stemoxydine, topical minoxidil, and uses dermarolling for hair loss but sees less impressive, patchy regrowth compared to others. Another person suggests some online results may be enhanced with hair fibers, not just medication.

community Very reluctantly starting Finasteride.

in Finasteride/Dutasteride 84 upvotes 9 months ago

A 23-year-old started taking 0.25 mg of Finasteride daily for hair loss after trying Minoxidil and derma rolling without success. People shared varied experiences with Finasteride, discussing potential side effects, effectiveness, and personal decisions regarding hair loss treatment.

community 200mcg Selenium stopped my hairloss

in Is this regrowth? 8 upvotes 9 months ago

A user reported that taking 20mg copper and 200mcg selenium completely stopped their hair loss. The conversation is about hair loss treatments.

community Hair Regrowth Protocol for the Brothers suffering

in Treatment 57 upvotes 11 months ago

The conversation discusses a hair regrowth protocol involving Dutasteride, Pyrilutamide, Stemoxydine, Minoxidil, Tretinoin, Oral Castor Oil, and L-Carnitine L-Tartrate. Some users are skeptical, particularly about the effectiveness and side effects of oral castor oil.

community Can I use Nizoral 2% if I don’t have any dandruff?

in Ketoconazole 49 upvotes 1 year ago

The conversation discusses using Nizoral 2% for hair loss treatment without having dandruff, with advice on allowing it to absorb for 10 minutes before rinsing and a personal experience of the product causing dry and itchy scalp.

community Where to Begin with Microneedling?

in Treatment 17 upvotes 1 year ago

User is considering microneedling to enhance hair regrowth after limited response to minoxidil and better results with finasteride and ketoconazole shampoo. Recommendations include using a 1.5mm derma roller once a week, avoiding minoxidil on microneedling days, and disinfecting the roller with isopropyl alcohol.

community 11 months on 5mg oral minoxidil

in Progress Pictures 978 upvotes 1 year ago

A user's 11-month progress using 5mg oral minoxidil for hair loss. The user reported significant hair regrowth, including on the beard and eyebrows, and experienced minor side effects like headaches and increased body hair.