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      community PP405 (Non) Update - Feb 2025

       36 upvotes 1 year ago
      The conversation discusses the delay in the PP405 Phase 2 study results, now expected by the end of 2025, and skepticism about research practices. There is also mention of optimism for Amplifica's AMP303 and a topical treatment in early testing.

      community Dut and min not working, what’s next?

       2 upvotes 1 month ago
      A 21-year-old male has been using finasteride, dutasteride, and oral minoxidil for hair loss without success and is considering trying RU58841, pyrilutamide, or clascoterone. Another user suggests checking vitamin levels, health conditions, and protein intake.

      community MinoxiBoost - SULT1A1 Enzyme booster journey

      in Minoxidil  7 upvotes 2 years ago
      The user has tried topical Minoxidil and oral Minoxidil for beard and scalp hair growth with minimal results, and has been on Finasteride for 7 months with stabilized scalp hair but no facial hair improvement. They are considering using a SULT1A1 enzyme booster to enhance results and are questioning its effectiveness without concurrent topical Minoxidil application.

      community finasteride and creatine

       6 upvotes 5 years ago
      Finasteride and minoxidil are effective for hair regrowth, but creatine may potentially increase hair loss due to higher DHT levels. Some users experienced hair thinning with creatine, while others saw no issues; many chose to stop creatine to prioritize hair health.

      community Dermatitis and Nizoral

      7 years ago
      A 27-year-old male experienced hair loss and dermatitis, which improved with tea tree oil and neem extract. He is considering using a 2% Ketoconazole solution for further treatment.

      community A rare case? Or a blind spot? Hair loss caused by low T + e2

      in Chat  10 upvotes 1 year ago
      Low testosterone and estradiol may contribute to hair loss, and blocking DHT without sufficient hormone levels might hinder regrowth. The discussion highlights the importance of hormone balance, with some considering supplements and lifestyle changes to support hair health.

      community Trying to eat Beetroot Powder and not get bald

       6 upvotes 2 years ago
      The user is concerned about hair loss and is using minoxidil while considering beetroot powder, which may affect testosterone and DHT levels. They are cautious about starting finasteride due to potential side effects.

      community Oral minoxidil dark circles. Did this improve over time for you?

       6 upvotes 1 month ago
      Oral minoxidil caused dark circles and visible veins for the user, who responded quickly to the treatment but lowered the dose to reduce side effects. Despite using finasteride and tretinoin, the user is considering stopping minoxidil if the side effects persist.

      community Does Creatine lower estrogen levels?

       4 upvotes 5 years ago
      Finasteride is being used for hair loss, and there is concern that creatine might raise DHT levels, potentially reducing finasteride's effectiveness. A dermatologist's guide advises avoiding creatine.

      community Bicalutamide and muscles growth

       7 upvotes 1 year ago
      A 30-year-old woman with androgenetic alopecia is considering bicalutamide to slow hair loss but is concerned about its impact on muscle growth due to its anti-androgen effects. Alternatives suggested include dutasteride, spironolactone, RU58841, and minoxidil, with concerns about bicalutamide's side effects.

      community Curious about 'nuclear' stacks

      in Research/Science  1 upvotes 1 year ago
      The conversation discusses using higher doses of minoxidil and finasteride, considering dutasteride, and exploring other treatments like RU58841 for hair preservation. The user reports no side effects after six months and is interested in advanced treatment combinations.

      community Creatine increases DHT?!?!

       8 upvotes 5 years ago
      Creatine may increase DHT, potentially affecting hair loss, but opinions vary. Users discuss using finasteride and alternatives like plant protein to manage hair loss.

      community I’m really tired of using minoxidil

      in Minoxidil  42 upvotes 2 years ago
      The user is frustrated with minoxidil's lack of results and is considering alternatives like oral minoxidil or finasteride despite concerns about side effects. Other suggestions include consulting a doctor, adjusting dosages, or considering a hair transplant.

      community Is tazarotene potentially better than tretinoin in combination with topical minoxidil?

       1 upvotes 10 months ago
      Tazarotene may be more effective than tretinoin when combined with topical minoxidil for hair loss due to its selective binding to RAR-beta and gamma, though it can cause irritation. Tazarotene's potency can lead to indirect inflammatory reactions despite potentially causing less irritation than tretinoin.

      community Minoxidil and seborrheic dermatitis

       4 upvotes 7 years ago
      Minoxidil use may worsen seborrheic dermatitis, causing itching and dandruff. Users consider stopping minoxidil or switching to foam to improve scalp condition.

      community PP405 mechanism question - looking for discussion

       7 upvotes 5 months ago
      PP405 may promote short-term hair growth by pushing follicles into the growth phase, but concerns exist about long-term effects due to lack of rest phases. Users discuss various treatments like finasteride, minoxidil, spironolactone, alfatradiol, and investigational drugs like KX-826 and GT20029 for hair maintenance and regrowth.

      community Can I mix minoxidil with stemoxydine?

       5 upvotes 4 years ago
      Mixing 1ml of minoxidil with 1ml of stemoxydine is discussed, with concerns about potential adverse effects. It is suggested that stemoxydine is a good solvent and can be mixed with minoxidil and finasteride.

      community How to get rid of Estradiol Problems

       5 upvotes 2 years ago
      The conversation discusses managing estradiol problems during finasteride treatment. Suggestions include stopping finasteride every 3 months for 2-3 weeks or reducing the dosage.

      community Anyone tried Kre Alkalyn instead of regular creatine for hair loss concerns?

       4 upvotes 1 month ago
      The conversation discusses concerns about hair loss potentially linked to regular creatine monohydrate use and considers switching to Kre Alkalyn, which some claim doesn't cause the same issues. A user argues that Kre Alkalyn and regular creatine are functionally identical once ingested, implying no difference in hair loss effects.

      community What can be the real reason of Finasteride SE ?

       18 upvotes 1 year ago
      Finasteride can cause side effects like erectile dysfunction and decreased libido, possibly due to increased estradiol from testosterone aromatization, especially in those with higher body fat. Side effects vary widely and may also be influenced by genetic factors or neurosteroid inhibition.

      community 25 years on finasteride - my experience

       943 upvotes 1 year ago
      A long-term finasteride user experienced side effects like sexual dysfunction, dry eyes, muscle weakness, and brain fog, which improved when they stopped the medication. They decided to stop finasteride again, questioning if maintaining hair was worth the negative impact on their well-being.

      community Losing grounds? 6.5 month fin/min

       7 upvotes 2 weeks ago
      A 23-year-old male using topical minoxidil, finasteride, ketoconazole, and biotin for 6.5 months feels his hairline is worsening and considers switching to oral minoxidil due to poor response to topical treatment. Users suggest checking vitamin deficiencies, particularly vitamin D, and advise patience, as hair loss treatments can take time to show results.

      community Won’t pp405 and gt20029 be patented and be almost unreasonably expensive

       29 upvotes 1 year ago
      Concerns about the potential high cost of new hair loss treatments, pp405 and gt20029, were discussed, with some users willing to pay a premium if they are effective. Alternatives like finasteride and minoxidil are mentioned as current, more affordable options, and there is speculation about future generic versions and black market availability.

      community Anybody else trying shou wu chih or just straight fo-ti/he shou wu

       3 upvotes 3 years ago
      The conversation discusses using shou wu chih or fo-ti/he shou wu for hair loss, with OP noticing stiffer beard and body hair. A user warns about potential liver damage from fo-ti and questions the effectiveness of alternative medicine.