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GlossaryChronic Inflammation (Long-term Inflammation)

long-term immune response causing tissue damage and disease

Chronic inflammation, also known as persistent inflammation, is a prolonged and often harmful immune response that can last for months or even years. Unlike acute inflammation, which is a short-term response to injury or infection, chronic inflammation can result from ongoing exposure to irritants, autoimmune disorders, or unresolved acute inflammation. This persistent state can lead to tissue damage and is associated with various diseases, including arthritis, cardiovascular disease, and certain types of alopecia.

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community How much would a high dose dutasteride scalp dht inhibition be?

in Finasteride/Dutasteride 10 upvotes 7 months ago

The conversation discusses the potential for high doses of dutasteride to completely inhibit scalp DHT and speculates whether this could cure baldness when combined with a topical antiandrogen. Specific dosages mentioned are 0.5 mg reducing scalp DHT by 55% and 2.5 mg by about 79%.

community Seborrheic dermatitis - can it cause long-term shedding (or telogen effluvium)?

in Advice 6 upvotes 4 years ago

A user is experiencing significant hair loss and scalp issues despite using Minoxidil, finasteride, and RU58841 since 2017. They switched to oral Minoxidil and are now on isotretinoin and topical corticosteroids for seborrheic dermatitis but continue to lose hair and seek advice on whether inflammation or treatment changes are the cause.

community antihistamine for scalp inflammation??

in Chat 6 upvotes 2 months ago

Cetirizine 10mg daily reduced hair shedding by 50% and lessened scalp itchiness. The user is considering long-term use for scalp inflammation and hair loss.

community Treating my DUPA via controlling inflammation

in Treatment 6 upvotes 9 months ago

The user has DUPA and suspects autoimmune activity as a cause. They have tried various treatments including finasteride, minoxidil, dutasteride, pyrilutamide, estrogel, hydrocortisone, and clobetasol, and are now seeking a long-term immunosuppressant.

community I made it to 30 with a full head of hair when I was balding at 20. I made it boys.

in Update 62 upvotes 3 years ago

User turned 30 with full hair thanks to Dutasteride and minoxidil. Switched from Dut to fin 2.5 mg daily for long-term health, also uses dermarolling, nizoral, and low inflammation lifestyle.

community Treatments to maintain alternative to finasteride/dutasteride

in Treatment 6 upvotes 3 years ago

A 29-year-old male experiencing hair loss due to TRT is using minoxidil and dermarolling but is hesitant to use finasteride or dutasteride due to potential side effects. He is considering low level laser therapy (LLLT), PRP, ketoconazole shampoo, and oral minoxidil as additional treatments. A reply suggests that without a DHT blocker like finasteride or dutasteride, other treatments may not be effective long-term.

community 3 Weeks After the Hair Transplant (before the ugly duckling phase). In my 20s, got some hope back

in Progress Pictures 292 upvotes 1 year ago

A user who underwent a hair transplant in their twenties and are now discussing the best treatments for long-term management of hair loss, such as finasteride and Minoxidil, as well as potential alternative treatment options like RU58841.

community Dutasteride SAVES your hair follicles: MAJOR BS on people who say it destroyed their hair permanently.

in Finasteride/Dutasteride 159 upvotes 11 months ago

The conversation discusses the effectiveness of hair loss treatments, specifically finasteride and dutasteride. The conclusion is that dutasteride significantly reduces DHT levels and may be more effective than finasteride for long-term hair retention, with some users reporting personal experiences and side effects.

community Testosterone and hair loss seeming irrelevance

in Research/Science 82 upvotes 1 year ago

The conversation is about the role of testosterone in hair loss and the effectiveness of different treatments. The conclusion is that DHT is the main culprit for hair loss, and finasteride has been proven to work long-term in maintaining and regrowing hair. Testosterone may have a minor effect, but it is not the primary cause of hair loss.

community Zyrtec (Cetirizine) antihistamine for hair growth compared to Minoxidil NIH study

in Minoxidil 35 upvotes 1 year ago

The conversation discusses the potential of topical cetirizine (Zyrtec) for hair growth in comparison to minoxidil, noting cetirizine's ability to reduce prostaglandin D2, which inhibits hair growth. Users share mixed experiences with cetirizine for allergies and scalp health, and there's a mention of the risk of dementia with long-term antihistamine use.

community My 2 year and 6 months progress. Finasteride 1 mg

in Progress Pictures 168 upvotes 2 years ago

A 31-year-old man shared his 2.6-year hair loss treatment progress, using 1 mg of finasteride daily, micro-needling every other week, and biotin vitamins, with no side effects and varying amounts of shedding. Other users discussed their own experiences with hair loss treatments, including the use of oral minoxidil and the long-term effectiveness of finasteride.

community Cetirizine (Zyrtec), to help with inflammation.

in Product 3 upvotes 2 months ago

The user experiences an itchy scalp and finds relief using shampoo and Zyrtec, which helps with inflammation. They are unsure if the issue is related to histamines or seborrheic dermatitis.

community Nizoral shampoo – really needed? How often? How long to apply?

in Ketoconazole 6 upvotes 1 year ago

User on finasteride for a decade and oral minoxidil for a month asks about Nizoral shampoo's effectiveness and usage. Dermatologist suggests it may help with seborrheic dermatitis and hair loss, but not necessary; others share mixed opinions.

community Scalp tension and thickness of the galea aponeurotica, inflammation and potential treatment pathways

in Research/Science 2 years ago

Scalp tension potentially affecting hair loss, and potential treatments for male pattern baldness such as Minoxidil, Finasteride and RU58841. Evidence from a study was discussed which suggests that the cause of MPB lies within the follicle itself and is not dependent on its surrounding environment.

community People need to start accepting that only medical therapy (Fin/Dut) can save your hair in the long run.

in Treatment 112 upvotes 10 months ago

Minoxidil can regrow hair but doesn't address the underlying issue of DHT, leading to continued hair loss. Users discuss their experiences with finasteride and dutasteride, mentioning side effects, personal outcomes, and alternatives like microdosing topical finasteride.

community The 'DHT itch' is real - notes from a casual bodybuilder

in Chat 115 upvotes 2 months ago

The "DHT itch" is real and likely due to inflammation at the hair follicle, exacerbated by increased testosterone or androgens. Treatments mentioned include dutasteride, minoxidil, finasteride, and various topical solutions.

community 0.5mg’s of Dut & was still thinning rapidly. Upped my dose to 2.5mg’s daily & added 5mg’s of Oral Minox. 1 month progress.

in Progress Pictures 8 upvotes 2 months ago

OP increased Dutasteride from 0.5mg to 2.5mg daily and added 5mg Oral Minoxidil, seeing progress after one month. They also used Nizoral Ketoconazole shampoo to reduce scalp inflammation.

community This and ketoconazole 2% life changing

in Ketoconazole 69 upvotes 1 year ago

The post discusses the user's experience with hair loss treatment using finasteride, clobetasol propionate, and ketoconazole shampoo. The conversation warns about the potential side effects of clobetasol, a powerful topical steroid, and emphasizes its short-term usage.

community Got a microscope camera. Here’s the difference between healthy and miniaturized hair

in Progress Pictures 492 upvotes 2 years ago

A user who shared progress pictures of their scalp using a microscope camera, demonstrating the difference between healthy and miniaturized hair. Various explanations for the cause of this were discussed, such as DHT build-up in scalp sebum causing an autoimmune response leading to inflammation and eventual hair loss, with some suggesting a do-it-yourself treatment involving adding ascorbic acid powder to shampoo.

community Exploring all options - Scalp tension theory

in Research/Science 9 upvotes 1 month ago

The conversation discusses the scalp tension theory as a potential factor in hair loss, alongside DHT, inflammation, and other mechanisms. Treatments mentioned include finasteride, minoxidil, and botox injections, with some users exploring additional methods due to varying effectiveness.

community After 3 years of shit with bad doctors and no working treatment I’m getting some hope (tiny hairs poppin)

in Progress Pictures 116 upvotes 4 months ago

A user shared their experience with hair loss treatments, noting improvement after switching from minoxidil and finasteride to dutasteride. They observed new hair growth and reduced scalp inflammation, expressing hope for further progress.

community I’ve been on dutesteride and oral minoxidil for two years now and I’ve only lost ground… 25m What should I do?

in Treatment 33 upvotes 7 months ago

A user on dutasteride and oral minoxidil for two years has experienced worsening hair loss and an itchy scalp. Suggestions include increasing medication doses, trying other treatments like RU58841, getting a scalp biopsy, and addressing potential inflammation through diet and topical treatments.

community Antihistamines stop my hair loss

in Treatment 24 upvotes 2 years ago

A user found that antihistamines stop their hair loss and related symptoms, but they experience side effects like sedation and chest pain. They are seeking alternative solutions or topical antihistamines to avoid systemic side effects.

community Finasteride, Nizoral and dermarolling 2 months update

in Finasteride/Dutasteride 207 upvotes 4 years ago

Hair loss treatments, specifically the use of Finasteride, Nizoral, and dermarolling; potential results from these treatments are discussed, along with potential side effects.

community 3 months progress with Finasteride 0.5mg/daily, Minoxidil foam5% 2x daily, Stemoxydine 2x daily, Microneedling(M8) 1.5mm 1x per week, Saw Palmetto 400mg/day, peppermint and jojoba oils daily, Ketoconazole 2% shampoo 3x/week, Purador shampoo/conditioner every day.

in Progress Pictures 334 upvotes 2 years ago

Jordan-Iliad has been using a combination of finasteride, minoxidil, stemoxydine, microneedling, saw palmetto, peppermint and jojoba oils, ketoconazole shampoo, and Purador shampoo/conditioner for 3 months to treat their hair loss with stunning results. They have also recently started taking oral minoxidil 1.25mg/day in hopes of achieving even better results over the next 3 months.

community My Theory Regarding a Cause and Cure for Androgenetic Alopecia

in Treatment 98 upvotes 4 years ago

Hair loss theory suggests imbalance between Vitamin D Receptor (VDR) and Androgen Receptor (AR) activation. Proposed treatment includes upregulating VDR, downregulating AR, and improving mitochondrial health.

community Is it okay to use topical fin/min immediately after dermastamping?

in Microneedling 26 upvotes 6 months ago

The conversation discusses the timing of applying Minoxidil and finasteride after microneedling. Opinions vary, with some suggesting immediate application and others recommending waiting to avoid skin irritation.

community Sunlight: Does it Stimulate Hair Growth or Hair Loss?

in Research/Science 61 upvotes 7 months ago

The conversation discusses whether sunlight exposure affects hair growth or loss, with mixed anecdotes and theories but no clear consensus. Some suggest moderate sunlight can benefit hair by providing vitamin D, while others doubt its effectiveness compared to treatments like Minoxidil or finasteride.

community It’s crazy how it’s 2018 and the only hair loss treatments we have feature undesirable side effects and/or aren’t even effective for many people.

136 upvotes 6 years ago

Hair loss treatments, including minoxidil, dermarolling, finasteride, dutasteride, hair transplants, hair systems, and shaving the head. The conversation covers various opinions on these treatments and mentions possible side effects as well as alternatives like wigs, vitamins, and lifestyle changes. The post expresses disappointment that there has been no major breakthrough in the field of hair loss treatments despite decades of research.

community Does 0.5 mg of finasteride reduce SCALP DHT the same as 1 mg?

in Finasteride/Dutasteride 15 upvotes 5 months ago

The conversation is about whether 0.5 mg of finasteride reduces scalp DHT as effectively as 1 mg. Users suggest that even lower doses like 0.05 mg can significantly reduce scalp DHT.