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      community [Nov 2019] The peptide AC 2 isolated from Bacillus-treated Trapa japonica fruit extract rescues DHT (dihydrotestosterone)-treated human dermal papilla cells and mediates mTORC1 signaling for autophagy and apoptosis suppression

       23 upvotes 6 years ago
      A peptide from Japanese water chestnut fruit may help with hair loss by suppressing DHT's effect on hair follicle cell death, potentially serving as a finasteride alternative. The treatment's effectiveness and safety in humans remain uncertain.

      community Jxl069 (pp405 api) week 8 update

       205 upvotes 1 year ago
      The user shared minimal results from using JXL-069 for hair loss, noting a slight lengthening of vellus hairs and plans to switch to a prodrug variant due to limited effectiveness. They also mentioned using finasteride and minoxidil, which have plateaued in results.

      community Amplifica: Hope or Cope? A Review of Their Pipeline

       9 upvotes 1 month ago
      Amplifica's AMP-303 showed a modest increase in hair growth, but results were inconsistent and potentially misleading. Hyaluronic acid and osteopontin are being explored for hair growth, with varying effects on different hair types and conditions.

      community Why isn't this a thing? Why isn't it even talked here?

       7 upvotes 5 years ago
      The conversation discusses the effectiveness of AMSbzs supplements in significantly increasing hair count, weight, and keratin content. The user questions why this treatment isn't more widely known despite its impressive results.

      community Rejux-3x - the copper peptide combo that tressless overlooks.

       1 upvotes 5 months ago
      Rejuv-3X, a topical blend with GHK-Cu, AHK-Cu, and JXL-089, is used for hair loss, offering a targeted option without finasteride's side effects. The user plans to combine it with microneedling for enhanced results.

      community Any chemists want to manufacture PP405 / JXL069? (Steps inside)

       89 upvotes 10 months ago
      The conversation discusses the synthesis and potential use of JXL069 and PP405 for hair loss treatment, with skepticism about their effectiveness and concerns about safety. Users mention that JXL069 has shown no results in hair growth, and there is confusion about its identity and effectiveness compared to PP405.

      community A few days on RU58841 and JXL069, are my eyes deceiving me?

       6 upvotes 5 months ago
      The conversation discusses a hair loss treatment regimen involving minoxidil, finasteride, RU58841, JXL069, and nizoral shampoo. The user reports seeing new black dots in areas where hair hasn't grown in years, suggesting potential regrowth.

      community Breaking news, new method to prevent hair loss

       1496 upvotes 2 months ago
      The conversation humorously discusses unconventional and satirical methods for preventing hair loss, such as using coffee and mayonnaise on the scalp. It mentions caffeine as a DHT blocker and jokes about various coffee-related treatments.

      community I want to attempt to use the MPC inhibitor JXL-069

      in Research/Science  14 upvotes 1 year ago
      The conversation discusses skepticism about group buys for hair loss treatments, highlighting issues with unverified chemicals and the risks involved. It suggests stabilizing with dutasteride and minoxidil, and considering a hair transplant instead of experimenting with untested products.

      community Juicero is not an analogy for PP405. Stop bringing that up.

       8 upvotes 8 months ago
      PP405 is a medicine, and Google Ventures is funding its development based on evidence from each phase, unlike their investment in Juicero, which was a trend-based gamble. Investing in medicine is a calculated risk, not reliant on being "cool."

      community Dermastamping — do you use hyaluronic acid as lubricant?

       3 upvotes 1 year ago
      The conversation discusses using high molecular weight hyaluronic acid after microneedling to form a protective barrier, though it's considered expensive and offers marginal improvement. Users share experiences with different microneedling tools like derma rollers, dermastamps, and Dr. Pen, with some opting not to use any products on the scalp.

      community Hair cloning breakthrough, this might just be the big one ?

       418 upvotes 6 months ago
      Japanese scientists discovered ABM cells, enabling successful human hair follicle cloning, potentially curing hair loss. The treatment may be available in Japan by 2028, but it will be expensive and require travel.

      community SCUBE 3 (the last hair bender)

       2 upvotes 1 year ago
      SCUBE3 and Amplifica's progress in hair loss treatment is being discussed, with inquiries about their current status and clinical trials. No specific updates or new information are provided in the conversation.

      community New cure? A new combo to dream with hair regeneration

       33 upvotes 1 year ago
      A stem cell and adenosine triphosphate cocktail showed promising results in hair regrowth for male and female mice, with potential for future clinical trials. Users humorously reacted to the success in mice, expressing hope for human application.

      community Chat are we gonna talk about john harper

       5 upvotes 1 year ago
      Some users believe John Harper's hair regrowth claims using dermarolling, coffee, and oils are misleading, while others defend his methods. The conversation highlights skepticism about alternative treatments and emphasizes finasteride, dutasteride, and minoxidil as proven solutions for hair loss.

      community HopeMed (Hmi115) is pissed at Absci (Abs-201)

       4 upvotes 2 weeks ago
      HopeMed is upset with Absci for allegedly using misleading information about HMI-115's performance compared to ABS-201. HopeMed plans to take legal action to protect its confidential data and trade secrets.

      community Neat trick, just turn Jewish to hide crown hair loss

       1200 upvotes 3 months ago
      The conversation humorously suggests using religious headwear to hide hair loss, mentioning Sikh turbans and Jewish kippahs. It also touches on cultural practices like circumcision and includes various jokes and comments about hair loss solutions.

      community Amplifica and AMP-303 clinical phase 1

       9 upvotes 2 years ago
      Amplifica is testing a compound called AMP-303 for hair loss, but it's not Scube3 or osteopontin. The timing for the results from the clinical trial is unknown.

      community a new supplement just released

       12 upvotes 8 years ago
      A dermatologist recommended a new supplement containing annurca apple, which reportedly doubles hair density and increases keratin after 60 days, to be used with finasteride. Some users are skeptical, considering it potentially ineffective or a marketing ploy, while others are open to trying it if it proves effective and affordable.

      community There could be a broadcast station nearby promoting 'Gr0wBand' or scalp massage!

       74 upvotes 10 months ago
      The conversation humorously discusses hair loss treatments, mentioning scalp massage, minoxidil, and the ineffectiveness of devices like the "Gr0wBand." It highlights the role of androgens in hair loss and suggests that increased blood flow from massage may not significantly impact hair growth.

      community Brewer's Yeast?

      in Question 8 years ago
      The conversation discusses using brewer's yeast for hair regrowth, either as a supplement or in a scalp masque. The user is considering adding it to their regimen.

      community Alopecia Areata Question

       2 upvotes 5 years ago
      A user with alopecia totalis, borderline universalis, seeks advice on getting into a Xeljanz trial or appealing insurance for coverage. They experienced significant hair regrowth but are now seeing hair loss again and want to try Xeljanz.