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GlossaryInner Root Sheath

layer of cells supporting and shaping the growing hair shaft

The Inner Root Sheath (IRS) is a layer of cells that surrounds and supports the growing hair shaft within the hair follicle. It plays a crucial role in shaping the hair and guiding it as it emerges from the scalp. The IRS is composed of three distinct layers: Henle's layer, Huxley's layer, and the cuticle of the inner root sheath, each contributing to the structural integrity and function of the hair follicle.

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community Topical Finasteride Doesn't Directly Reduce 5ar Enzyme on Scalp

in Finasteride/Dutasteride 72 upvotes 1 year ago

Topical Finasteride doesn't directly reduce 5ar enzyme on scalp and has the same mechanism as oral, needing to go through the liver. Users debate the accuracy of this information and discuss various studies and experiences.

community Minoxidil is connecting the hair on the inner part of my arms

in Satire 1 year ago

This conversation is about a user who has been using Minoxidil for nine months and just noticed hair growing on the inner part of their arms. Responses to this post suggest that they should continue using it, with an increase in frequency from 5% twice a day, as well as trying finasteride if needed.

community How many Dut pills does it take to have Franz Kafka's hairline?

in Satire 48 upvotes 1 year ago

The post and conversation discuss hair loss treatments and the uncertainty of their results. Some users suggest that artificial hair systems might be the best solution, while others express preference for maintaining a mature hairline rather than aiming for a youthful one.

community DHT levels after 4 weeks of Fina and 8 weeks of Fina + 4 weeks of Duta

in Update 35 upvotes 5 years ago

The user reported early stage diffuse hair thinning and increased DHT levels after 4 weeks on Finasteride and 8 weeks on Finasteride plus 4 weeks on Dutasteride, despite the medications being authentic and stored properly. They are considering increasing their Dutasteride dosage due to the lack of side effects and are unsure if the treatment is helping their hair.

community 9 months on Finasteride 1,25mg + HRT

in Transgender 17 upvotes 7 months ago

The conversation is about the results of using hormone replacement therapy (HRT) with estrogen and finasteride for hair loss, and switching from finasteride to bicalutamide as an anti-androgen treatment. The user shared before and after photos to discuss the effectiveness of these treatments.

community 1 year of finasteride, minoxidil (capsules) and rosemary oil. (Side note I also… lost weight, had a LOT of therapy for unresolved childhood trauma and started arresting my unhelpful thinking/ useless self hatred/ judging myself and others/ hair loss) 🥹

in Progress Pictures 1013 upvotes 11 months ago

The user shared a one-year progress of treating hair loss with finasteride, minoxidil capsules, and rosemary oil, and also improved mental health by addressing childhood trauma and changing negative thought patterns. Commenters congratulated the user on both hair regrowth and mental health progress, with one asking for advice on overcoming self-hatred and low confidence.

community PCOS female who posted before; saw Endo today. prescribed spironolactone and minox 5%

in Update 1 upvotes 1 year ago

PCOS female visited doctor for hair loss concerns, prescribed spironolactone and minox 5%. Doctor advised against finasteride or dutasteride, user considering self-medication with dutasteride.

community Pyrilutamide vs Ru58841 thoughts

in Research/Science 8 upvotes 1 year ago

The user has been using Pyrilutamide (Pyril) for hair loss for a month alongside finasteride/dutasteride since 2021 but hasn't seen results. They are considering switching to RU58841 due to its many success stories, despite being skeptical about the legitimacy and testing of Pyrilutamide.

community Topical minoxidil 3 months results

in Progress Pictures 624 upvotes 2 years ago

This conversation is about a user named "mr_mime125" who experienced results from using topical finasteride (0.1%) and minoxidil (5%) solution 1.5 ml twice a day for the first two months followed by just minoxidil (5%) 1 ml once a day in the last month, resulting in a drastic improvement to their hairline. Other users discussed their progress while asking questions and offering encouragement.

community Roughly 1.5 years progress. Dut, Fin, Minox, RU.

in Progress Pictures 795 upvotes 2 years ago

A user's progress with treatments for hair loss, including Dutasteride, Finasteride, Minoxidil, and RU. Other members of the conversation provided tips such as using Microneedling and Tretinoin to increase regrowth and wounding areas of the scalp that are thinning in order to fill them in.

community Going to try and reverse MPB naturally.

in Treatment 55 upvotes 2 years ago

A user is trying to reverse male pattern baldness (MPB) naturally by taking high doses of Vitamin D, improving diet, exercising, reducing stress, and other lifestyle changes, but plans to use finasteride if no results are seen in 60 days. Other users are skeptical, advising medical treatments like finasteride and warning against potential vitamin D overdose and the ineffectiveness of natural remedies for genetic hair loss.

community Dr. Rassman’s topical liposomal finasteride - gyno question

in Finasteride/Dutasteride 13 upvotes 3 years ago

User discusses topical liposomal finasteride for hair loss, hoping to avoid breast growth side effect. Conversation includes using minoxidil, fluridil, and dermarolling, and mentions minimal systemic absorption of liposomal finasteride.

community Balding, short, small penis. What is the point of living…

in Treatment 405 upvotes 3 years ago

A 24 year old male struggling with the physical and mental effects of balding, being short, and having a micropenis. Suggested treatments include taking medications such as finasteride and minoxidil, lifting weights, and trying not to compare himself to others.

community hairloss in my 20s has ruined my life.

in Research/Science 373 upvotes 1 month ago

A person in their 20s is struggling with hair loss, using treatments like minoxidil and finasteride. Suggestions include self-improvement, therapy, hair transplants, and focusing on acceptance and confidence.

community Is getting a haircut a traumatic experience for anyone else?

in Chat 340 upvotes 1 month ago

Hair loss causes anxiety during haircuts, with some using minoxidil, finasteride, or hair transplants to cope. Others manage by cutting their own hair or accepting baldness.

community Drinking minoxidil lands human in ICU with shock and heart failure

in Minoxidil 804 upvotes 3 months ago

A person mistakenly drank an entire bottle of topical minoxidil, leading to ICU admission with shock and heart failure. The incident highlights the dangers of ingesting topical treatments and the importance of proper usage and dosage.

community Embraced baldness. Time to leave this subreddit

in Chat 876 upvotes 4 months ago

A user shared their positive experience of embracing baldness after years of trying treatments like Minoxidil and finasteride. They found happiness and confidence by shaving their head, despite some social challenges, and encouraged others to focus on their attitude and seek therapy if needed.

community NW6 - 12 months progress - Dut/Oral Min/2% Keto Shampoo

in Progress Pictures 141 upvotes 5 months ago

User shared 12-month hair loss progress using oral minoxidil, oral dutasteride, and 2% ketoconazole shampoo. They detailed their medication regimen and dosages.

community M21 I stopped finesterid 3 Months ago... this is how it looks now

in Finasteride/Dutasteride 176 upvotes 6 months ago

A user stopped finasteride due to side effects and rapid hair loss, considering a hair system. Others suggested alternatives like dutasteride, minoxidil, and topical finasteride.

community Is there a topical androgen receptor blocker so we don't have to fuck with the enzyme and destroy our allopregnanolone, but go and hit the end target straight?

in Treatment 47 upvotes 7 months ago

The conversation discusses topical androgen receptor blockers for hair loss, mentioning Clascoterone, Pyrilutamide, GT20029, and RU58841. Ketoconazole's effectiveness and application methods are also debated.

community Planning to for Hair transplant

in Transplants 104 upvotes 9 months ago

The conversation is about someone considering a hair transplant due to ineffective hair loss treatments, with suggestions ranging from trying a hairpiece to continuing with medications like finasteride and minoxidil, and waiting for new treatments. Some advise against a transplant due to the extent of hair loss and the cost, while others share different views on the effectiveness of transplants and non-surgical options.

community Jordan Peterson got a sick hair transplant!

in Transplants 1077 upvotes 10 months ago

The conversation is about Jordan Peterson allegedly getting a hair transplant, with various users mocking his way of speaking and debating the ethics of him potentially hiding the procedure. Some users discuss the natural look of the transplant and the implications of getting one at an older age.

community How uninformed the general public is about hair loss

in Chat 318 upvotes 10 months ago

The conversation highlights the general public's lack of knowledge about hair loss, with various ineffective remedies suggested, such as not wearing hats or using hair fibers. The only effective treatments mentioned for male pattern baldness are medications like minoxidil and finasteride, and hair transplants.

community My conclusive research on Hairline and most other facets of appearance

in Research/Science 11 months ago

The user emphasizes hydration, androgen receptors, and a 7-day ejaculation recovery period for appearance enhancement. They suggest Minoxidil, finasteride, and RU58841 for hair loss, along with a diet rich in animal fats, specific exercises, and fasting.

community 19 yo destroyed hairline even though using Fin/min/microneedling for 16months/11months/3months … Idk what to do.

in Progress Pictures 261 upvotes 11 months ago

A 19-year-old has been using finasteride, minoxidil, and microneedling to treat hair loss with no regrowth, feeling mentally affected by it. Advice given includes continuing treatment, considering a hair transplant, addressing potential vitamin deficiencies, and possibly switching to dutasteride or adding ketoconazole shampoo.

community Diffuse thinning is the worst man

in Chat 248 upvotes 11 months ago

The conversation is about the struggles of dealing with diffuse thinning at a young age and the lack of significant improvement after using treatments like finasteride and minoxidil. Some suggest additional methods like derma rolling, microneedling, and hair fibers, while others share their own experiences and encourage persistence with treatment.

community Chris Bumstead Hair Tansplant at Now Hair Time

in Transplants 477 upvotes 1 year ago

Chris Bumstead got a hair transplant at Now Hair Time, and the discussion focuses on why he chose a less reputable clinic despite having the means for a better one, with some suggesting it was for financial gain. The conversation also touches on concerns about the naturalness of the hairline and the potential impact of his steroid use on the transplant's success.

community This community was super helpful to me a while ago, but it feels so good to be off finasteride

in Shaved/buzzed 766 upvotes 1 year ago

The post is about a user who stopped using finasteride for hair loss and shaved his head, receiving positive feedback. The conversation includes discussions on side effects of finasteride, including potential fertility issues, and alternatives like minoxidil, dermarolling, and hair systems.

community What hurts the most is that only minority of us are balding

in Chat 252 upvotes 1 year ago

The conversation discusses the emotional impact of early hair loss in men, with many feeling isolated and self-conscious. Some users also mention the lack of awareness about potential treatments like Minoxidil and Finasteride.

community If anyone else feels like they’re too far gone for a hair transplant or can’t tolerate finasteride, I highly recommend trying a hair system! You have nothing to lose and it can change your life. I understand the worries and concerns, as I was very nervous/scared before taking the leap. AMA

in Hair Systems 394 upvotes 1 year ago

The conversation discusses the use of hair systems as a solution for hair loss. Users share their experiences, highlighting the natural look, confidence boost, and maintenance requirements of hair systems, while also addressing concerns about cost, stigma, and potential drawbacks.