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GlossaryEnzyme Inhibition

reduction or cessation of enzyme activity by specific molecules

Enzyme inhibition refers to the process by which the activity of an enzyme is reduced or stopped. This can occur through various mechanisms, such as competitive inhibition, where an inhibitor molecule competes with the substrate for the active site, or non-competitive inhibition, where the inhibitor binds to a different part of the enzyme, altering its shape and function. Understanding enzyme inhibition is crucial in fields like pharmacology and biochemistry, as it can influence drug design and metabolic regulation.

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community to all people who cannot tolerate anti androgens (loe dose topical fin, pyrilutamide, CB) i am getting desperate, looking for a solution

in Research/Science 13 upvotes 1 year ago

The user tried Minoxidil without success, and Finasteride worked but caused sexual side effects even at a very low dose. They are seeking alternative treatments for hair loss as they cannot tolerate anti-androgens and are also in therapy for mental health.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 44 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community What’s your experience with RU58841?

in Treatment 21 upvotes 1 year ago

People shared mixed experiences with RU58841 for hair loss; one person saw no improvement, another had significant gains and uses it with finasteride, while a third had an allergic reaction to the premixed solution. Some mix RU58841 powder into minoxidil themselves.

community Inhibition of 5 alpha-reductase activity in human skin by zinc and azelaic acid????

1 upvotes 6 years ago

The post discusses using a topical tincture containing zinc, azelaic acid, and other ingredients to inhibit 5 alpha-reductase activity for treating hair loss. The user plans to try this natural alternative before using finasteride or RU58841.

community How much would a high dose dutasteride scalp dht inhibition be?

in Finasteride/Dutasteride 10 upvotes 7 months ago

The conversation discusses the potential for high doses of dutasteride to completely inhibit scalp DHT and speculates whether this could cure baldness when combined with a topical antiandrogen. Specific dosages mentioned are 0.5 mg reducing scalp DHT by 55% and 2.5 mg by about 79%.

community Topical Dutasteride - Non-Hormonal, Side Effect Free 5ARI?

in Treatments 372 upvotes 3 months ago

Topical dutasteride is suggested as a low side-effect treatment for hair loss, with a proposed dose of 0.025% 1ml/day. It is considered better than finasteride due to its even inhibition of DHT isoforms and lower systemic absorption.

community Efficacy of different dutasteride doses vs finasteride

in Research/Science 123 upvotes 1 year ago

Dutasteride doses matter for hair loss treatment and are more effective than finasteride. RU58841 is suggested for better gains, but side effect profiles should be considered.

community A systematic bro-science review of DHT, 5AR, neurosteroids, sexual health and 5AR inhibitors

in Research/Science 37 upvotes 2 years ago

Hair loss treatments, specifically 5AR inhibitors, can impact neurosteroids and sexual health. The effects of topical fin/dut on tissue-specific DHT levels are unclear.

community For those of you who are getting facial skin side effects (aging, dark circles) from minoxidil, try this, it helped me.

in Minoxidil 11 upvotes 3 years ago

The conversation provides tips to reduce facial skin side effects from Minoxidil, such as changing pillowcases, sleeping on the back, careful application, hydration, and taking breaks. One reply suggests that alcohol in Minoxidil formulations, not Minoxidil itself, may cause skin aging.

community Increased adipose tissue (being overweight) in males may increase likelyhood of finasterde side effects

in Research/Science 29 upvotes 2 months ago

Being overweight may increase finasteride side effects due to higher aromatase activity converting testosterone to estradiol. Maintaining a healthy weight could reduce these side effects.

community 5 years of min / finasteride, no longer slowing loss.

in Finasteride/Dutasteride 37 upvotes 1 year ago

A user's experience of slowing hair loss while taking minoxidil and finasteride, and the various treatments suggested to help halt or reverse the process.

community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

in Research/Science 739 upvotes 2 years ago

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

community A meta analysis of 18 popular hair loss treatments. An 2022 guide on efficacy. From finasteride and minoxidil to caffeine shampoo, saw palmetto and biotin. 96 Scientific References included.

in Research/Science 102 upvotes 2 years ago

Most hair loss treatments are ineffective; only finasteride, dutasteride, and minoxidil show effectiveness.

community Obviously, all of us who are serious take antiandrogens and growth stimulants - what else are you doing lifestyle wise, dietary wise, and regiment wise to maximize your results?

in Treatment 21 upvotes 4 months ago

The user follows a hair loss treatment routine including Propecia, oral minoxidil, ketoconazole, and plans to switch to dutasteride. They also focus on lifestyle changes, dietary supplements, and are considering laser therapy.

community Fluridil downregulates androgen receptor expression?

in Research/Science 1 upvotes 10 months ago

Fluridil may decrease the number of androgen receptors in hair follicles by up to 95%. This suggests a different action mechanism from other non-steroidal antiandrogens like RU58841, indicating they might be used together.

community Is anyone taking creatine while on fin and/or dut?

in Finasteride/Dutasteride 33 upvotes 4 months ago

The conversation discusses the use of creatine while on finasteride and/or dutasteride for hair loss. Opinions vary, with some users reporting no issues and others experiencing accelerated hair loss, suggesting effects are individual.

community Fats on your Head to Stop Hair Loss?

in Research/Science 140 upvotes 9 months ago

The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

community Anagenic announces the launch Pyrilutamide on their website. Are you excited ?

in Treatment 80 upvotes 2 years ago

The launch of Pyrilutamide as a potential hair loss treatment, with people discussing whether it is better than treatments like finasteride and minoxidil. Some participants have also discussed the risks associated with importing drugs from China.

community Am i too obsessed with hair loss prevention? And Is This obsession healty? Am i the only one? Look at my collection In This picture: Oral finasteride/ topical finasteride/ minoxidil 5% + tretinoin/ minoxidil 5%/ Alfatradiol 0.025%/Stemoxydine 5%/ dermapen/ketoconazole 1%/viviscal/procyanidin B2.

in Chat 49 upvotes 2 years ago

User obsessed with hair loss prevention shares collection of treatments, including oral and topical finasteride, minoxidil, dermapen, and more. Others suggest adding RU58841, laser helmet, and PRP, while some advise dropping certain treatments for long-term manageability.

community Why do I have the feeling that this subreddit is flooded by Kintor employees?

in Chat 132 upvotes 2 months ago

Users discuss aggressive promotion of Koshine 826, suspecting Kintor employees are behind it. Concerns are raised about its effectiveness, with some preferring alternatives like finasteride and minoxidil.

community A hair model who does beauty ads and has 3 million followers claims he went from almost a Norwood 3 to a perfect hairline in 8 months on only Minoxidil and Rosemary oil. Curious, what are people’s thoughts?

in Chat 1 year ago

This conversation discusses the results of a model who claims he went from almost a Norwood 3 to a perfect hairline in 8 months using only Minoxidil and Rosemary oil. The replies suggest that this could be realistic but long-term results would require additional treatments like finasteride or other medications to prevent further hair loss.

community 22 years since the last major development

in Technology 50 upvotes 3 years ago

The conversation discusses the lack of significant advancements in hair loss treatments since the introduction of finasteride 22 years ago, with many expressing frustration over the failure of new projects and skepticism about future developments. Some users mention hair transplants and other potential alternatives like Alfatradiol and Fluridil, but acknowledge finasteride's dominance in the market due to its effectiveness and affordability.

community The most depressing things about hair loss for me

in Chat 23 upvotes 3 years ago

The emotional impact of hair loss and the risks associated with common treatments such as finasteride, dutasteride, minoxidil, RU58841, and Fluridil. People discussed their personal experiences with these treatments, including potential side effects and lowered fertility. Hair transplants were also mentioned as a possible solution.

community I am actually regrowing my hairline without minoxidil or finasteride (mechanical stimulation)

128 upvotes 6 years ago

Regrowing hairline without the use of Minoxidil or Finasteride, and instead using mechanical stimulation such as Derma Roller, Nizoral, Zinc Pyrithione, Scalp Massage, Scalp Exercise, Fish Oil and other topical solutions. It is cautioned that there are risks associated with not using medically-prescribed treatments, but it is suggested to consider mechanical stimulation in addition to those prescribed treatments.

community DHT and 5AR respect post, it's importance within the brain

in Research/Science 111 upvotes 8 months ago

The conversation discusses whether to use finasteride for hair loss, considering its role in inhibiting DHT and 5AR, which can affect brain function and mood. Some users report anxiety and depression from finasteride, while others do not experience these side effects and emphasize the importance of DHT for brain and prostate health.

community This sub in a nutshell when it comes to medicine. Oral Minoxidil isn’t that bad

in Chat 446 upvotes 1 year ago

The post and conversation are about the use of oral Minoxidil (Min), Finasteride (Fin), and RU58841 for hair loss treatment, with mixed opinions on their safety and effectiveness.

community Physician here AMA – 30M oral Fin 1-1.25 mg daily

in Update 47 upvotes 2 years ago

Hair loss treatments, specifically the use of finasteride, microneedling and potentially oral minoxidil. People discussed their experiences with finasteride, its effects on sexual behaviors, as well as potential solutions such as tadalafil or using other growth factor signal peptides for hope in curing male pattern baldness.

community A warning to those using or thinking about using Dutasteride – Follow-up

in Finasteride/Dutasteride 18 upvotes 3 years ago

The post and conversation are about the long-term side effects of using Dutasteride and Finasteride for hair loss, including issues like raised liver enzymes, high cholesterol, and loss of libido. The user advises regular blood work and careful monitoring for those using these treatments.

community My DHT levels have increased after taking 0.25mg Fin for 47 days!

in Finasteride/Dutasteride 184 upvotes 2 weeks ago

A user experienced increased hair shedding and unchanged DHT levels after taking 0.25mg of finasteride for 47 days, leading them to increase the dose to 0.5mg. Others discussed varying experiences with finasteride, minoxidil, and the importance of measuring scalp DHT.

community Are topicals with caffeine useful to promote hairgrowth?

in Research/Science 3 upvotes 6 months ago

The user is asking if caffeine topicals are effective for hair growth, noting they already use Minoxidil and finasteride. They are unsure if caffeine topicals are beneficial or a waste of money.