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GlossaryInflammatory Mediators

substances released to initiate and regulate inflammation

Inflammatory mediators are substances released by immune cells and other tissues in response to injury or infection, which help to initiate and regulate the inflammatory response. These can include cytokines, prostaglandins, and histamines, among others, and they play crucial roles in signaling pathways that lead to symptoms like redness, swelling, and pain. Understanding these mediators is essential for developing treatments for conditions like alopecia, where inflammation can contribute to hair loss.

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community NMN Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress

Robbsaber in Research/Science 14 upvotes 8 months ago

NMN shows promise in promoting hair growth by reducing oxidative stress and weakening androgens. It may be a beneficial addition to hair loss treatments like Minoxidil and Finasteride.

community Lilly to seek first approval of an autoimmune drug for hair loss

watermelonicecream in Research/Science 19 upvotes 3 years ago

Eli Lilly's drug baricitinib showed effectiveness in treating alopecia areata, with higher doses resulting in significant hair regrowth compared to placebo. The treatment is not for male pattern baldness.

community Pirfenidone - The answer to fibrosis and baldness

uttftytfuyt in Treatment 19 upvotes 3 years ago

Pirfenidone is suggested to treat fibrosis and baldness by blocking inflammation markers and reducing collagen. It is also available as a gel for scar removal.

community I started rapidly diffuse thinning at 22. I'm 42 now and have as much hair as I did at 16. AMA

karlallan in Treatment 443 upvotes 4 years ago

Hair loss treatments like finasteride, minoxidil, ketoconazole, PRP, and microneedling helped maintain hair for 20 years. Research and try evidence-based treatments for best results.

community New Research- Creatine Increasing Scalp DHT Without Corresponding Serum DHT Increase

longdongsilver696 in Research/Science 119 upvotes 8 months ago

Creatine may increase scalp DHT without affecting serum DHT, potentially speeding up male pattern baldness (MPB) for those genetically prone. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community Lion Mane Part 2: Microneedling with Topicals, beneficial compounds, maybe?

L3onidas-Kelevra in Microneedling 1 upvotes 8 months ago

The conversation discusses microneedling techniques and the use of Minoxidil, copper peptides, EGF, FGF, ceramides, and hydration serums to enhance hair growth. It explores optimizing scalp conditions and the potential benefits of various compounds in conjunction with microneedling.

community Comprehensive Microneedling Guide

throwoveraccount in Microneedling 294 upvotes 2 years ago

Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

community The theory that explains everything. The malloclusion theory has been proven.

joaopassos4444 in Research/Science 27 upvotes 1 year ago

Brian Dye's theory links skeletal malocclusion type II to hair loss, suggesting it's a blood flow issue. Treatments mentioned include minoxidil, finasteride, and anti-inflammatory drugs like benaxoprofen.

community Finally Managed to Download Somebody's Alex pdf so try to share it

Sorry_Alex_ThrowAway in Research/Science 70 upvotes 11 months ago

The conversation discusses a shared PDF about hair loss treatments, which might help those not seeing results with Minoxidil, Finasteride, and RU58841. Some users are skeptical about the content's value and the price charged for it.

community So what’s really the deal with dutasteride hairline ruining claims?

YourElectricityBill in Finasteride/Dutasteride 72 upvotes 2 years ago

The potential effects of dutasteride on hair loss, with some users reporting it improved their hairline while others experienced worsened hair loss or shedding. Other treatments discussed include minoxidil and finasteride, as well as RU58841.

community Hopefully a logical question regarding dermarolling.

Practical-Chart in Microneedling 4 years ago

A user discusses using dermastamping for hair loss and questions the timing of applying a mixture of peppermint oil, spearmint oil, rosemary oil, and castor oil due to their anti-inflammatory effects. They wonder if waiting 10 hours after stamping would be more effective.

community dht becoming active since the scalp is tight en cause inflammation

DashcubeBM in Research/Science 6 upvotes 2 years ago

User discusses tight scalp causing hair loss and suggests treatments like scalp massages, PRP, saw palmetto, and eucapil. They share their experience with saw palmetto and eucapil and consider adding PRP and scalp massages for better results.

community How do you distinguish miniaturised hairs from velus hairs regrowing from dormant follicles around temples?

Kyrie_illusion in Chat 8 upvotes 4 years ago

The conversation discusses difficulty in distinguishing between new hair growth and thinning hair at the temples after using microneedling and a rosemary peppermint topical for four weeks. The advice given is to wait a few months to see if the hairs grow out to determine their nature.

community Opinions on Scalp fibrosis and DHT?

TqmLad in Research/Science 9 upvotes 2 years ago

The conversation discusses the theory that scalp fibrosis contributes to male pattern baldness (MPB) by increasing DHT concentration, and mentions treatments like Minoxidil. The user seeks opinions on the theory and the effectiveness of scalp massages.

community Topical dutasteride, oral minoxidil, dermastamp, oral castor oil. Two months of difference

Emptybox1996 in Progress Pictures 7 upvotes 3 years ago

User sees subtle regrowth after two months using topical dutasteride, oral minoxidil, dermastamp, and oral castor oil. Others suggest waiting a few more months to properly evaluate results.

community 2 month update (30M) - finasteride, minoxidil, dermaroll, nizoral

ProgressDaily08 in Progress Pictures 286 upvotes 3 years ago

Hair loss progress update: finasteride, minoxidil, dermaroll, nizoral. Dermaroll depth 1.5mm, 3 times a week.

community Going to start the sulforaphane experiment

katanared in Treatment 17 upvotes 3 years ago

A user shared their experience with hair loss treatments, including minoxidil and finasteride, and their negative side effects. They outlined a new treatment plan involving microneedling, various supplements, minoxidil foam, ketoconazole shampoo, and an anti-inflammatory diet, with plans to document progress over three months. Another user responded, indicating their own similar efforts were a waste of money.

community 36 MTF - Born balding, went bald, recovering hair

swishyliv in Journals / Progress Pictures 559 upvotes 8 months ago

A 35-year-old MTF individual shared their hair recovery journey, using Minoxidil, Dutasteride, Estradiol, Spironolactone, Microneedling, and Exosomes. They recently had a hair transplant and are documenting the healing process.

community Why I deleted my YouTube channel Part I

Rider_Of_Roach in Update 118 upvotes 3 years ago

A YouTuber named Kevin, also known as Rider_Of_Roach, who deleted his YouTube channel due to personal attacks and controversy surrounding his views on hair loss treatments. He advocated for FDA-approved treatments like finasteride and minoxidil but faced backlash from those who disagreed with him. The conversation also discusses his past trolling behavior and a lawsuit he filed against a website that published false information about him. Despite some disagreements, many viewers appreciated his research-based content and hope to see him return in the future.

community This sub is very toxic towards people who don’t blindly follow the fin mafia

PeterGriffin147 in Treatment 226 upvotes 1 year ago

The conversation criticizes the negative attitude towards those concerned about side effects from hair loss treatments like finasteride and minoxidil, or who prefer natural remedies. Specific treatments discussed include finasteride, minoxidil, rosemary oil, and RU58841, with an agreement that finasteride and minoxidil are proven effective.

community Could low blood flow to the head cause an increased rate of thinning?

degutisd in Chat 27 upvotes 3 years ago

The user started using finasteride, minoxidil, and biotin for male pattern baldness (MPB) and is experiencing rapid thinning. They are questioning if low blood flow to the head could be contributing to their hair loss.

community Starting the microneedling only journey. M35 with diffuse thinning. Derminator 2, keto, vitamins and castor oil.

microneedleguy in Microneedling 15 upvotes 2 years ago

A user is starting a microneedling regimen for hair loss, using Derminator 2, ketoconazole shampoo, castor oil, and multivitamins. They plan to provide monthly updates on their progress.

community How much does diet affect hair loss?

Several_Enthusiasm95 in Chat 45 upvotes 1 year ago

The conversation suggests that changing diet and lifestyle has little to no effect on male pattern baldness (MPB), which is largely determined by genetics. Some individuals noted personal improvements in hair condition with healthier diets, but the consensus is that diet alone cannot prevent or reverse MPB.

community Is microneedling supposed to be a blood bath? 1mm dermastamp

PE_Venture in Microneedling 41 upvotes 10 months ago

The conversation is about someone experiencing a lot of bleeding from using a 1.0mm microneedling device for hair loss treatment and asking if it's normal. Various users suggest that the bleeding is excessive and recommend using shorter needles or less pressure, while others share their own microneedling practices with different needle lengths and no bleeding.

community I am actually regrowing my hairline without minoxidil or finasteride (mechanical stimulation)

MyThinningConfidence 128 upvotes 6 years ago

Regrowing hairline without the use of Minoxidil or Finasteride, and instead using mechanical stimulation such as Derma Roller, Nizoral, Zinc Pyrithione, Scalp Massage, Scalp Exercise, Fish Oil and other topical solutions. It is cautioned that there are risks associated with not using medically-prescribed treatments, but it is suggested to consider mechanical stimulation in addition to those prescribed treatments.

community New study shows that microneedling is an ineffective hair loss treatment

No-Music689 in Research/Science 1 year ago

The effectiveness of microneedling as a hair loss treatment, with evidence from studies and anecdotal accounts from other users. It is suggested that combining microneedling with minoxidil or finasteride may be more effective than using microneedling alone, although some people have had success using only microneedling.

community When someone posts a scalp tension theory

DermaBroller in Satire 264 upvotes 3 years ago

Hair loss theories discussed include poor blood flow, scalp tension, inflammation, and DHT. Treatments mentioned are massaging scalp, minoxidil, finasteride, and RU58841.

community What would be an ideal diet for promoting health for what's left/regrowth?

Sliqueee in Question 38 upvotes 6 years ago

The conversation discusses an ideal diet for promoting hair health, emphasizing biotin, collagen, vitamins C and E, zinc, selenium, anti-inflammatory foods, and blood circulation. It also mentions using finasteride, minoxidil, and dermarolling for hair regrowth.

community How I started reversing Male Pattern Baldness naturally ?

surkut in Question 6 upvotes 7 years ago

The user reversed male pattern baldness using a pro-thyroid diet, lifestyle changes, and scalp stimulation exercises, without Minoxidil or Finasteride. They reported reduced dandruff, itchiness, oiliness, and experienced hair regrowth and thickening over 15 months.

community Anyone here going the “natural” route?

SprawlWino in Scalp Massage 48 upvotes 2 years ago

People discussing their experiences with natural treatments for hair loss, such as essential oils, deep scalp massages, anti-inflammatory measures, and supplements. Most of the replies suggest that these treatments are not effective and recommend medication such as minoxidil or finasteride instead.