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GlossaryImmune Dysfunction (Immune System Disorder)

immune system fails to protect the body properly

Immune Dysfunction, also known as Immune System Disorder, refers to a condition where the immune system does not function properly. This can manifest as an overactive immune response, leading to autoimmune diseases where the body attacks its own tissues, or an underactive response, resulting in immunodeficiency where the body is unable to effectively fight off infections. Examples include conditions like rheumatoid arthritis (autoimmune) and HIV/AIDS (immunodeficiency).

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community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

in Research/Science 65 upvotes 1 year ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

community He used Dutasteride for 20 years. Interview

in Treatment 107 upvotes 1 month ago

Dutasteride has been used for 20 years with some hair thickness improvement but no dramatic regrowth. The user also experimented with minoxidil, tretinoin, and peptides like BPC 157 for potential benefits in hair density and quality.

community Fin/dut increase in estrogen and autoimmune diseases

in Chat 6 upvotes 1 year ago

The conversation discusses the link between increased estrogen and autoimmune diseases, with a focus on avoiding soy and milk. It also mentions treatments like Minoxidil, finasteride, and RU58841 for hair loss.

community Rare Non responder to Finasteride, Dutasteride, and oral minoxidil

in Minoxidil 78 upvotes 9 months ago

A user did not respond to finasteride, dutasteride, and oral minoxidil for hair loss after four years of treatment and is considering scalp micropigmentation (SMP). Other users suggest the hair loss pattern may indicate alopecia areata and recommend seeing a dermatologist.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Could microneedling for the next 5 years cause any permanent damage?

in Microneedling 22 upvotes 1 year ago

Microneedling for hair loss and its potential long-term effects. Some users believe it can cause fibrosis and scar tissue if done too frequently or deeply, while others claim it has improved their hair loss when done correctly. There is limited scientific research on the topic.

community Goodbye tressless. I’ve decided to give in to my hairloss.

in Update 594 upvotes 1 year ago

Kitchen_Plastic_2847 had been fighting hair loss since 2019-2020 and was initially successful in regrowing his hair with finasteride. However, after contracting Covid three times back to back at the start of 2021, he started to lose his hair again. He found a new dermatologist who prescribed him oral minoxidil along with finasteride, but eventually decided it wasn't worth spending all the money to try and save his hair.

community Scalp tension and thickness of the galea aponeurotica, inflammation and potential treatment pathways

in Research/Science 2 years ago

Scalp tension potentially affecting hair loss, and potential treatments for male pattern baldness such as Minoxidil, Finasteride and RU58841. Evidence from a study was discussed which suggests that the cause of MPB lies within the follicle itself and is not dependent on its surrounding environment.

community I’m 14 years old and I’m losing more hair than my dad. I’ve gone to the doctor 2 times because of this and I’ve received no help. I’m starting to feel like It’s worthless and my hairs gonna look like this forever. I don’t know how anyone could help me but it’s always worth a shot.

in Treatment 4 years ago

A 14 year old who is experiencing hair loss and has not received any help from the doctor, with advice being given to try different doctors, get tested for underlying conditions and intolerances, buzz it short as an option and treatments that could slow down or reverse the hair loss such as minoxidil, finasteride, RU58841 and addressing the cause of the hair loss.

community I lost the fight against MPB at age 22 despite being on treatments.

in Finasteride/Dutasteride 72 upvotes 1 year ago

The user "ajsr8" shared their story of hair loss despite being on treatments. They started using finasteride in 2019 and later tried topical minoxidil, but it didn't seem to work. They also experienced side effects from other treatments. They are considering cutting off their hair and stopping the medications if there is no improvement in three months. Other users suggested trying different treatments and getting a blood test to check for underlying conditions.

community C’est terrible - at my wits end

in Female 443 upvotes 1 year ago

A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.

community Physician here AMA – 30M oral Fin 1-1.25 mg daily

in Update 47 upvotes 2 years ago

Hair loss treatments, specifically the use of finasteride, microneedling and potentially oral minoxidil. People discussed their experiences with finasteride, its effects on sexual behaviors, as well as potential solutions such as tadalafil or using other growth factor signal peptides for hope in curing male pattern baldness.

community My Theory Regarding a Cause and Cure for Androgenetic Alopecia

in Treatment 97 upvotes 4 years ago

Hair loss theory suggests imbalance between Vitamin D Receptor (VDR) and Androgen Receptor (AR) activation. Proposed treatment includes upregulating VDR, downregulating AR, and improving mitochondrial health.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 42 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community Boys I am just a gonner. What on earth is my scalp even going through. Looks like world war 3. Pyril 3 months. Topical melitonin/progesterone/fin, dut, fin, oral min, laser trash, anus stimulation. Nothing. Donor area is decimated 😂.

in Progress Pictures 83 upvotes 2 years ago

Treating Seborrheic Dermatitis, a fungal scalp condition which can cause hair loss. Treatments discussed include antifungal shampoos, cold showers, exfoliating the scalp, taking Vitamin D, and stimulating the prostate through the anus.

community Lost density 60% all over scalp in 120 days (4months)

in Update 10 upvotes 6 months ago

A user lost 60% hair density in 4 months, started finasteride and microneedling, and has greasy, flaky, yellowish scalp. They are awaiting biopsy results, and another user suggested trying ketoconazole shampoo.

community Take A Vitamin D Blood Test!!!

in Treatment 48 upvotes 2 years ago

Low Vitamin D can cause hair shedding, and taking 5000 IU of Vitamin D daily reduced shedding significantly. Vitamin D deficiency is common and correcting it can benefit overall health.

community Autoimmune disease and balding

in Update 12 upvotes 6 months ago

A user diagnosed with Crohn's disease is concerned it might contribute to balding. They have been using keto shampoo, finasteride, and oral minoxidil, which improved their hair but not significantly.

community Is itching related to hair loss?

in Treatment 54 upvotes 2 years ago

Hair loss, which is sometimes accompanied by itching. Treatments discussed include Minoxidil, finasteride, RU58841 and ketocazole shampoo.

community Fuck hair loss; acquire beard.

in Shaved/buzzed 938 upvotes 2 years ago

A user's transformation from an accountant to a spartan with a full beard, discussing the potential of DUPA and alopecia areata, as well as treatments like vitamins, topicals, and natural treatments for potential regrowth.

community Everyone is ignoring that plasma finasteride levels are 100x lower with topical compared to oral.

in Research/Science 138 upvotes 4 months ago

Topical finasteride results in plasma levels 100 times lower than oral finasteride, potentially reducing systemic side effects. Users report similar efficacy with fewer side effects, suggesting a preference for topical application.

community 25F and have been losing my hair for 10 years. Been to doctors, no issues with thyroid or hormones. No history of hair loss in my family. Wtf do I do?

in Question 12 upvotes 6 years ago

A 25-year-old woman has been losing hair for 10 years despite normal thyroid, hormone levels, and B12 supplementation. She has used Minoxidil with limited success and is considering hair transplants, Propecia, or shaving her head and wearing wigs.

community Pyrilutamide Phase 2 Results Release Date: June 2022

in Research/Science 106 upvotes 2 years ago

Hair loss treatments discussed include Minoxidil, Finasteride, and RU58841. Pyrilutamide Phase 2 results are expected in June 2022, with hopes for a better alternative to current treatments.

community Embraced baldness. Time to leave this subreddit

in Chat 870 upvotes 4 months ago

A user shared their positive experience of embracing baldness after years of trying treatments like Minoxidil and finasteride. They found happiness and confidence by shaving their head, despite some social challenges, and encouraged others to focus on their attitude and seek therapy if needed.

community Not everyone should immediately go on Fin if they are starting to bald

in Finasteride/Dutasteride 21 upvotes 11 months ago

The conversation suggests that people should consult a dermatologist to understand their type of hair loss before starting treatments like finasteride or dutasteride, especially if they have autoimmune issues or low DHT. Some participants believe in starting treatment like finasteride immediately if hair loss is due to DHT, while others recommend ruling out other causes and considering minoxidil first, especially for younger individuals.

community I hate it when people write off your hairloss info because “you’re not a doctor.”

in Treatment 76 upvotes 1 year ago

A user shared their frustration about their cousin's refusal to take their advice on using finasteride for aggressive hair loss, despite the cousin's desperation and current use of minoxidil and consideration of PRP injections. The user, who has done extensive research, suggested the cousin needs a 5ar inhibitor, but the cousin dismisses the advice because the user isn't a doctor.

community 3 months progress with Finasteride 0.5mg/daily, Minoxidil foam5% 2x daily, Stemoxydine 2x daily, Microneedling(M8) 1.5mm 1x per week, Saw Palmetto 400mg/day, peppermint and jojoba oils daily, Ketoconazole 2% shampoo 3x/week, Purador shampoo/conditioner every day.

in Progress Pictures 337 upvotes 2 years ago

Jordan-Iliad has been using a combination of finasteride, minoxidil, stemoxydine, microneedling, saw palmetto, peppermint and jojoba oils, ketoconazole shampoo, and Purador shampoo/conditioner for 3 months to treat their hair loss with stunning results. They have also recently started taking oral minoxidil 1.25mg/day in hopes of achieving even better results over the next 3 months.

community Prolactin’s role in antitumor activity of the immune system – a safety concern for HMI-115?

in Research/Science 3 upvotes 1 year ago

Hair loss discussion includes treatments Minoxidil, Finasteride, and RU58841. Prolactin's role in immune system's antitumor activity raises safety concerns for HMI-115.

community The ultimate regiment to reverse hairloss

in Treatment 6 upvotes 1 year ago

The conclusion of the conversation is that the user "Shakalakaplaka" shares their comprehensive hair loss regimen, which includes various treatments targeting different pathways such as DHT, inflammation, fibrosis, immune system, testosterone, gut problems, and scalp health. The effectiveness of the regimen is not confirmed, and some users express skepticism or request before and after pictures for credibility.

community Is it ok to take Xeljanz (A jak inhibitor) while taking finasteride?

in Finasteride 2 upvotes 7 years ago

The conversation is about whether it is safe to take Xeljanz, a JAK inhibitor, while also taking finasteride for hair loss. The concern is that Xeljanz weakens the immune system, which could be risky.