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GlossaryInterleukin-1 Receptor Antagonist

naturally occurring protein that inhibits inflammatory molecule interleukin-1

Interleukin-1 Receptor Antagonist (IL-1RA) is a naturally occurring protein that inhibits the activity of interleukin-1 (IL-1), a molecule involved in inflammatory responses. By blocking IL-1 from binding to its receptor, IL-1RA helps reduce inflammation and is used in treatments for conditions like rheumatoid arthritis and other inflammatory diseases.

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community HLT Megathread on HMI-115 (key takeaways in comments)

in Research/Science 40 upvotes 1 year ago

HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 667 upvotes 1 month ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community Solving Hair Loss with Research at MIT

in Research/Science 590 upvotes 1 month ago

Hair loss treatments like minoxidil, finasteride, TDM-105795, and PP405. MIT is hosting a hackathon to find innovative hair loss solutions.

community Perez Hilton Had 3 Transplants.. Yet Losing Hair.. Someone Explain?

in Transplants 71 upvotes 1 year ago

The conversation discusses Perez Hilton's hair loss despite having three hair transplants. Participants suggest that hair loss can continue after a transplant if maintenance treatments like finasteride and minoxidil are not used, and that transplanted hair can still be susceptible to loss.

community NMN Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress

in Research/Science 14 upvotes 5 months ago

NMN shows promise in promoting hair growth by reducing oxidative stress and weakening androgens. It may be a beneficial addition to hair loss treatments like Minoxidil and Finasteride.

community I am having Success with RU58841 and 1mm Derma Roller

in Microneedling 19 upvotes 2 years ago

A user reported success with RU58841 and a 1mm derma roller for hair regrowth, noting significant improvement in hair density and reduced scalp visibility. They also mentioned using minoxidil and black castor oil in the past, with mixed results.

community ORAL MIN ,DERMAROLLING AND RU58841 PROGRESS 3 months (18,M)

in Progress Pictures 80 upvotes 1 year ago

The conversation is about an 18-year-old's progress with hair regrowth using oral Minoxidil, dermarolling, and RU58841 over three months, starting treatment after beginning to lose hair at 16. Participants are impressed with the improvement and encourage continued treatment.

community Breaking hair loss news! GT20029 is a resounding success!

in Product 138 upvotes 7 months ago

GT20029, a new hair loss treatment, shows promising results but only a slight improvement over placebo. People are cautiously optimistic, discussing its potential and combining it with existing treatments like Minoxidil and Finasteride.

community When do you think Breezula will be released to the public?

in Chat 34 upvotes 3 years ago

The conversation discusses expectations for the release of Breezula, a new hair loss treatment, and compares it to existing treatments like finasteride. Some believe Breezula could be a game-changer due to fewer side effects, while others await more permanent solutions like hair follicle cloning.

community Anyone else just waiting until the real pyrilutamide and then GT20029?

in Chat 1 year ago

The user is hesitant to use finasteride due to potential hormonal side effects and is waiting for the release of pyrilutamide, a new hair loss treatment. Other users suggest trying finasteride, warning about potential regret if hair loss progresses in the meantime.

community Kintor has announced the results for their human Phase I trials of GT20029

in Research/Science 257 upvotes 1 year ago

The conversation discusses the potential of a new hair loss treatment, GT20029, which may prevent hair loss by destroying androgen receptors on the scalp. Users express hope for the treatment's success and speculate on its usage routine, effectiveness, and possible side effects.

community What is the real impact of dutasteride on neurosteroids? A little review of 2 scientific datas

in Research/Science 21 upvotes 4 months ago

Dutasteride at 0.5 mg/day does not significantly alter allopregnanolone levels, but higher doses (2.5 mg/day) do. Dutasteride may also have anti-neuroinflammatory effects, but the impact on neurosteroids is still debated.

community Possible explaination for Finasteride Reflex Hyperandrogenicity

in Finasteride/Dutasteride 6 upvotes 2 years ago

The user has been using finasteride and minoxidil for hair loss but experienced worsening temple recession. They suspect they might be more sensitive to testosterone and are considering trying RU58841 or CB 03 01 as additional treatments.

community 13 WEEKS MICRONEEDLING MONOTHERAPY

in Microneedling 187 upvotes 1 year ago

A user's experience with microneedling monotherapy and potential treatments such as finasteride, minoxidil, Stemoxydine, rosemary oil, peppermint oil, and RU58841 for reversing hair loss.

community can someone please tell me its going to get better? im bawling my eyes out

in Female 67 upvotes 2 years ago

A 16-year-old girl is experiencing hair loss, which has worsened despite using minoxidil and multivitamins. Suggestions include broader hormone testing and considering other treatments like spironolactone if the hair loss is due to androgenic alopecia.

community For Once and For All: Is It the DHT in the Scalp That Matters, Not the DHT in Your Bloodstream?

in Treatment 83 upvotes 2 months ago

DHT in the scalp, not the bloodstream, is crucial for hair loss. Treatments discussed include finasteride, minoxidil, dutasteride, and microneedling.

community Will rubbing olive oil on my thinning spots when I get the dht itch slow down/maybe stop balding?

in Research/Science 3 years ago

Olive oil may temporarily relieve DHT itch but won't stop balding. Finasteride and Minoxidil are recommended for hair loss treatment.

community 1 year after my Hair Transplant

in Progress Pictures 161 upvotes 1 year ago

Hair transplant after 1 year shows great results. Treatment done in Turkey, patient from Pakistan living in Germany.

community 1 year regime. Stabilizing a bit

in Progress Pictures 81 upvotes 5 months ago

A 30-year-old man using minoxidil for hair loss is seeing stabilization but no significant regrowth. He is hesitant about finasteride due to potential side effects and is seeking alternative methods to promote hair growth.

community 1 year topical fin/min coupled with frontal HT

in Progress Pictures 192 upvotes 10 months ago

The user experienced significant hair improvement after one year using topical finasteride and minoxidil, combined with a hair transplant at the front. They switched from oral to topical finasteride due to side effects and are satisfied with the results, especially at the temples.

community 1.5 years of Fin, switch 3 months ago to Dut, with 5 moths of Min too

in Progress Pictures 104 upvotes 2 years ago

User switched from Fin to Dut for better hair loss results, using 0.5mg Dut and 1ml Min daily. Some discuss potential side effects and benefits of Dut compared to Fin.

community Am i too obsessed with hair loss prevention? And Is This obsession healty? Am i the only one? Look at my collection In This picture: Oral finasteride/ topical finasteride/ minoxidil 5% + tretinoin/ minoxidil 5%/ Alfatradiol 0.025%/Stemoxydine 5%/ dermapen/ketoconazole 1%/viviscal/procyanidin B2.

in Chat 49 upvotes 2 years ago

User obsessed with hair loss prevention shares collection of treatments, including oral and topical finasteride, minoxidil, dermapen, and more. Others suggest adding RU58841, laser helmet, and PRP, while some advise dropping certain treatments for long-term manageability.

community Shed 2 years into finasteride and minoxidil

in Minoxidil 8 upvotes 3 months ago

A user has been on finasteride for 1.5 years and minoxidil for 2 years, experiencing worsening hair shedding, losing 300+ hairs per wash. They are concerned if this indicates the medicine isn't working and are seeking others' experiences.

community Does it look like improvement? 3 months on oral Minoxidil

in Is this regrowth? 799 upvotes 4 months ago

A user shared their 3-month experience with oral Minoxidil and nearly a year on finasteride, asking if a hair transplant might still be needed. Responses varied from congratulatory remarks on visible improvement to advice on sticking with treatments despite initial shedding.

community Recent recipient of a 5000 graft hair transplant in Istanbul….

in Transplants 245 upvotes 8 months ago

A user underwent a 5000 graft hair transplant in Istanbul, which included 900 beard grafts, after previously using finasteride with limited success. The procedure cost £4500, including transport and aftercare in both Istanbul and the UK.

community Fin- 4.5 months, Min-2.5 months, still long way to go

in Progress Pictures 64 upvotes 9 months ago

The user has been treating hair loss with 1mg oral finasteride daily, 1mg topical minoxidil twice daily, and microneedling twice a week. They report improved hair quality and density but are still experiencing shedding.

community starting out Nizoral shampoo, do I buy more bottles after I finish or switch back to traditional shampoo?

in Ketoconazole 62 upvotes 1 year ago

Using Nizoral shampoo intermittently and reassessing scalp condition after each bottle, potentially adding in other tools to target seb derm, and alternating between Pura D'Or and Nizoral for a healthy and clean scalp.

community 50 years old 4.5 months on Fin

in Finasteride/Dutasteride 28 upvotes 3 years ago

A 50-year-old user shared their positive experience with hair regrowth using finasteride, minoxidil, biotin, pumpkin seed oil, derma rolling, biotin shampoo, and Nizoral. They reported significant improvement in hair density and regrowth, especially in the crown and mid-scalp areas, with no side effects.

community Dutasteride 4.5 months really struggling what should I do

in Finasteride/Dutasteride 18 upvotes 6 days ago

The user has been on dutasteride for 4.5 months after switching from finasteride due to hair thinning, and is experiencing significant hair loss despite also using minoxidil and microneedling. Many responses suggest that dutasteride takes time to show results, often requiring patience for up to a year or more, and recommend not stopping finasteride abruptly to avoid shedding.

community Does this mean it's finally working

in Finasteride/Dutasteride 2 upvotes 3 months ago

The user started using topical minoxidil in June 2023 and switched to a new finasteride preparation and vitamin D supplements a month ago. They noticed reduced hair shedding recently and are hopeful for regrowth.