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      community Earliest we can get legitimate pyrilutamide

      in Research/Science  46 upvotes 2 years ago
      Pyrilutamide, a drug in phase 3 trials in China, potentially becoming available in late 2023 or early 2024; Finasteride being used as a current treatment for hair loss; and the possibility of joining a group buy for black market versions of Pyrilutamide.

      community Pyrilutamide ,the molecule’s true nature

      in Research  302 upvotes 3 months ago
      Pyrilutamide is a selective AR antagonist with a high binding affinity, making it effective in competing with DHT for androgen receptors. The 1% concentration is more effective than the 0.5%, but the latter may suffice for mild hair loss; the drug is considered a good option for those avoiding 5AR blockers due to side effects.

      community GT20029 China Phase II Trial For AGA Reached Primary Endpoint

      in Research/Science  136 upvotes 7 months ago
      The GT20029 tincture, a topical androgen receptor degrader, showed significant hair growth and good safety in a China Phase II trial for male androgenetic alopecia (AGA), with the 1% dose twice weekly identified as optimal. The company plans to initiate Phase III trials in China and Phase II in the U.S., and the treatment also shows promise for acne.

      community Quick word of advice for you guys wondering if you're balding

      in Chat  160 upvotes 1 year ago
      User noticed scalp showing at 26, started finasteride at 28, and saw hair improvement by 30. Others shared similar experiences and advised trusting personal observations and trying finasteride early to prevent further hair loss.

      community 1 year progress Topical Fin/Min, Dermaroller

      in Progress Pictures  878 upvotes 2 years ago
      A 1-year progress report from a person who used topical finasteride and minoxidil, as well as dermarolling, to combat hair loss. Replies discussed the impressive results achieved, recommended further treatments, and cautioned against using oral minoxidil due to its potential side effects.

      community Been on topical finasteride and minox for a year

      in Progress Pictures  32 upvotes 4 months ago
      User has been using topical finasteride and minoxidil for a year, seeing regrowth only on the hairline, not the crown. They also use keto shampoo, rosemary oil, and microneedle weekly, and are considering switching to oral treatments.

      community Fin raised my estrogen but also testosterone?

      in Finasteride/Dutasteride  17 upvotes 9 months ago
      A user experienced initial side effects from finasteride, including erectile dysfunction and emotional changes, but later noticed increased muscle mass and assertiveness. Hormonal tests showed elevated estrogen and prolactin levels, which slightly decreased over time; the user plans lifestyle changes to see if they help.

      community Pyrilutamide US Phase 2 Trial?

      in Research/Science  27 upvotes 2 years ago
      The Phase 2 trial for Pyrilutamide in the US, which started a year after the China trials, and inquiring about any available information on when it will finish. Treatments discussed include Minoxidil, Finasteride, and RU58841.

      community Why does finasteride stop working?

      in Finasteride/Dutasteride  26 upvotes 1 month ago
      Finasteride may seem less effective over time due to increased DHT sensitivity or aging, but it still suppresses DHT. Switching to dutasteride offers stronger DHT suppression but may increase estrogen levels.

      community KX-826 Pyrilutamide1% coming soon

      in Update  152 upvotes 3 months ago
      KX-826 Pyrilutamide 1% is launching soon, and users are discussing its potential benefits and drawbacks compared to other treatments like Minoxidil and finasteride. Some users are skeptical about its effectiveness, while others are hopeful it will be a safer alternative.

      community This sub after taking Finasteride for one day

      in Satire  904 upvotes 3 months ago
      The conversation humorously discusses the side effects of finasteride, particularly sexual dysfunction. Users share mixed experiences, with some reporting issues and others not.

      community Hair journey since august, help!

      in Is this regrowth?  21 upvotes 5 days ago
      The conversation is about hair loss and treatments, with suggestions to use finasteride or dutasteride as DHT blockers and minoxidil for regrowth. Oils and shampoos are considered ineffective for androgenic alopecia without these medications.

      community Hair regrowth after 8 months alhamdullah

      in Minoxidil  1415 upvotes 1 week ago
      A 30-year-old male saw significant hair regrowth after 8 months using minoxidil, finasteride, microneedling, and Nizoral shampoo. He experienced no side effects from finasteride and credited his success to this regimen.

      community Hair Loss Results After 8 Months of Dutasteride

      in Progress Pictures  229 upvotes 2 weeks ago
      The user experienced increased hair density after 8 months of using dutasteride and 6 months of oral minoxidil. Some users joked about side effects, while others discussed the effectiveness of various treatments like finasteride and rosemary oil.

      community Hair looks extremely thin under sunlight!

      in Chat  26 upvotes 1 month ago
      A 22-year-old male experiencing diffuse thinning is using oral minoxidil and finasteride but notices his hair looks thin in sunlight. Suggestions include using hair products, considering topical minoxidil, addressing seborrheic dermatitis, and possibly trying dutasteride or a hair transplant.

      community Hair Loss Due To Chlorine and Hard Metals In Water?

      in Research/Science  1 upvotes 1 month ago
      Hair loss possibly caused by chlorine and heavy metals in water was addressed by using a shower filter, ketoconazole shampoo, and PRP sessions, which stopped the hair loss but did not lead to regrowth. Other users suggested similar experiences and solutions, emphasizing the importance of a good water filter and patience for potential regrowth.

      community Hair Loss Treatments and Hair Transplant

      in Progress Pictures  4 upvotes 1 month ago
      The user is experiencing hair loss and is using oral finasteride, considering adding RU58841 and microneedling, and planning a hair transplant. They are seeking advice on whether to wait for treatment results or proceed with the transplant.

      community Hair loss steps, guide to beginners or anyone experiencing hair loss

      in Treatment  1 upvotes 1 month ago
      The conversation discusses a hair loss treatment regimen involving finasteride, dutasteride, spironolactone, bicalutamide, oral estradiol, microneedling, and minoxidil. The regimen aims to reduce androgenic alopecia by blocking DHT and androgens, with a caution about potential feminizing effects.

      community Hair follicle cloning is already possible

      in Chat  38 upvotes 1 month ago
      Hair follicle cloning is claimed to be possible but not widely available due to potential safety issues, such as cancer risks. Current treatments like finasteride and dutasteride are not effective for everyone, and there is frustration over limited access to these medications.

      community Hair Oils can be DANGEROUS and this is a case study. He lost all his hair.

      in Treatment  7 upvotes 1 month ago
      Hair oils can cause severe allergic reactions, as seen in Jermel Brown's case, leading to significant health issues and legal action for damages. Users discussed concerns about various hair oils, including Mielle and Kiehl's, with some experiencing hair loss and others using treatments like Minoxidil and Finasteride to address damage.

      community Hair loss 30F - thoughts on red light therapy vs min/fin?

      in Female  6 upvotes 1 month ago
      The conversation discusses hair loss treatments for a 30-year-old female, comparing red light therapy with minoxidil and finasteride. Concerns about hormonal impact and potential pregnancy are raised, with suggestions to consider spironolactone and microneedling, while emphasizing the importance of consulting a dermatologist.

      community hair loss treatment myths that perplex me

      in Treatment  8 upvotes 1 month ago
      Grapefruit juice doesn't significantly affect finasteride or dutasteride. Drinking topical minoxidil is risky; saw palmetto is less effective than finasteride or dutasteride for hair loss.