Treatments for hairloss, such as using AR receptor blockers and degraders, to see if follicles can regenerate in the long term. The conversation also discusses how hair transplants could be a potential solution.
A user proposed genetically engineering scalp stem cells to stop androgen receptors from causing hairloss. Others discussed the feasibility, existing research, and potential issues with this approach, including targeting the correct cells and unintended effects.
The conversation discusses the effectiveness of reducing DHT for hairloss treatment and explores alternative approaches like reducing androgen receptor sensitivity. Specific treatments mentioned include finasteride, dutasteride, pyrilutamide (KX-826), GT20029, and RU58841.
The conversation discusses whether creatine causes hairloss for those using finasteride or dutasteride, with some suggesting creatine might increase DHT or upregulate androgen receptors, potentially leading to hairloss. Others argue the evidence is not conclusive, citing limited studies and personal anecdotes, with some avoiding creatine as a precaution.
A 24-year-old male experienced an increase in estradiol levels and symptoms like gynecomastia and excessive sweating after using Minoxidil for hairloss. His estradiol levels decreased after he stopped using Minoxidil.
The conversation discusses the role of DHT in male hairloss and the effectiveness of treatments like Finasteride, which reduces DHT, and RU58841, which blocks DHT from binding to scalp receptors. The user debates the trade-offs between maintaining hair and having a healthy endocrine system, suggesting RU58841 might allow for both.
Hairloss treatments discussed include Minoxidil, Finasteride, RU58841, and Nizoral shampoo. Nizoral's effectiveness is debated, with some suggesting it works as a weak antagonist for androgen receptors, while others attribute its benefits to anti-fungal and anti-inflammatory properties.
RU and Pyri block androgen receptors to prevent hairloss but may also hinder hair regrowth since they prevent testosterone, which can stimulate hair growth, from binding to these receptors. The user is questioning if this understanding is correct.
User experienced sudden, rapid hairloss after a year on 2.5mg oral minoxidil. They are hesitant to use finasteride due to anxiety and depression concerns.
The user is addressing hairloss with scalp botox, scalp massage, nizoral shampoo, various vitamins and supplements, and natural nitric oxide boosters like citrulline malate and beetroot powder. They are also considering a mouthpiece to reduce snoring and improve sleep.
Hairloss treatments discussed include Minoxidil, Finasteride, RU58841, ass hair transplant, topical Viagra, castration, and transitioning to female. A user mentions an experimental drug called M4U-5 (Mousteride) that turns you into a mouse.
The conversation discusses the complexity of hairloss causes, suggesting that DHT sensitivity alone doesn't fully explain it. Treatments mentioned include finasteride and dutasteride.
Hairloss treatments, including minoxidil, dermarolling, finasteride, dutasteride, hair transplants, hair systems, and shaving the head. The conversation covers various opinions on these treatments and mentions possible side effects as well as alternatives like wigs, vitamins, and lifestyle changes. The post expresses disappointment that there has been no major breakthrough in the field of hairloss treatments despite decades of research.
A user shared their personal theory on hairloss, suggesting it's caused by reduced blood flow and scalp calcification rather than DHT, and claimed to have stopped their hairloss by massaging the scalp, using acid peels, and applying oils and copper peptides. They have not noticed further hairloss for six years since starting this routine.
The conversation discusses androgen receptor degraders for hairloss, highlighting their potential advantages over traditional AR blockers like RU58841 and pyrilutamide. Concerns about the safety and cost of these treatments are also mentioned.
Minoxidil and caffeine are discussed for hairloss treatment. The user questions the logic of combining them due to their opposing effects on adenosine receptors.
Scalp biopsies are crucial for diagnosing hairloss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hairloss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.
GT20029, a new hairloss treatment, shows promising results but only a slight improvement over placebo. People are cautiously optimistic, discussing its potential and combining it with existing treatments like Minoxidil and Finasteride.
The conclusion of the conversation is that the user should consider using treatments such as finasteride, minoxidil, and RU58841 to potentially reverse their hairloss. Other suggestions include using hairloss concealers and maintaining a healthy diet.
The conversation discusses GT20029 as a potential hairloss treatment that could act like a cure by targeting androgen receptors in scalp hair follicles. Specific treatments mentioned include GT20029, with a user expressing hope that it could make male pattern baldness obsolete.
A 25-year-old male with DUPA (diffuse thinning including the donor area) has not seen improvement after 14 months on finasteride. He's considering switching to dutasteride (DUT) after advice from a hairloss YouTuber and is also contemplating trying RU58841.
The conversation discusses why CB-03-01, a potential hairloss treatment, isn't widely discussed despite evidence of its effectiveness and safety. Some users mention other treatments like melatonin, procianidin b2, and RU58841, debating their effectiveness and safety.
17-alpha-estradiol may work for hairloss by inhibiting 5-alpha reductase, similar to finasteride. It might lower testosterone in the scalp, reducing DHT conversion.
A 21-year-old male managed to control his hairloss using Nizoral, RU58841, and finasteride, but experienced increased scalp itchiness after starting creatine, which subsided upon stopping creatine. Users shared mixed experiences on whether creatine affects hairloss, with some reporting negative effects and others seeing no change or defending its benefits.
