A gel of keratin microspheres promotes hairfolliclegrowth, showing similar effectiveness to minoxidil in mice. The treatment activates hairgrowth pathways and reduces inflammation, with potential applications in drug delivery for hair-related disorders.
Hairgrowth can be induced without stopping DHT, as seen with Minoxidil. HMI115 may work by promoting folliclegrowth, not targeting the root cause of hair loss (DHT).
A 20-year-old experiencing hair shedding after starting oral finasteride is advised to continue treatment and consider adding topical minoxidil. Shedding is normal, and patience is needed for hair regrowth.
PP405 is a new hair loss treatment in phase 2 trials that may promote hairgrowth by increasing lactate production and activating hairfollicle stem cells. It could potentially replace hormone-disrupting treatments like Minoxidil and finasteride.
TDM-105795 showed promising hairgrowth results, with higher efficacy than placebo and minimal side effects. It activates dormant hairfollicle stem cells and may maintain gains without immediate loss, unlike minoxidil.
He Shou Wu (Fo Ti) extract was found to prolong the hairgrowthphase, inhibit 5-alpha-reductase (like finasteride), reduce androgen receptors, and increase growth factors, potentially outperforming minoxidil in recovering hairfollicle size after DHT exposure. Two compounds, emodin and TSG, are identified as responsible for these effects and warrant further investigation.
New potential hair loss treatment uses molecules from hairy moles to stimulate folliclegrowth. Topical solution requires less frequent application, like Botox injections a few times per year.
The conversation discusses why DHT (dihydrotestosterone) negatively affects scalp hair but promotes growth elsewhere on the body. Various opinions include genetic predispositions, differences in hairfollicle reactions to DHT, and the potential role of Omega-3 in reducing inflammation and promoting hair health.
PP405 is not a cure for hair loss but may reactivate dormant hairfollicles, similar to minoxidil. It is unlikely to help with miniaturized or vellus hairs and is still in trial phases, with availability expected around 2030.
Hair regrowth in transfems is more effective due to hormonal changes, specifically estrogen, which keeps hair in growthphase longer. Treatments mentioned include anti-androgens, sex hormones, and DHT blockers like finasteride.
Finasteride prevents further hair loss by blocking DHT, while minoxidil stimulates hairgrowth by prolonging the active phase of hairfollicles. Stopping minoxidil can lead to loss of regrown hair because finasteride does not address the same growth mechanism.
Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hairgrowth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.
Androgenetic alopecia is caused by DHT affecting hairgrowth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hairgrowth.
Microneedling is effective for hairgrowth, especially when combined with finasteride and minoxidil, but concerns exist about potential long-term skin damage. Users report increased collagen and elastin deposition, but the long-term effects on the scalp remain uncertain.
The conversation discusses hair loss linked to BDNF-increasing nootropics like Semax and Lions Mane. Suggested topical treatments include capsaicin, beta-glucan, and ginseng to counteract TGF-B activation.
A 38-year-old female is experiencing hair loss despite having almost undetectable DHT levels after using dutasteride. Suggestions include checking for PCOS, thyroid issues, adjusting diet, considering the impact of birth control, and trying treatments like tretinoin, redensyl, retinol, and minoxidil with derma stamping.
The "Big 3 Stack" for hair loss treatment, which includes Minoxidil for hair density improvement, Ketoconazole shampoo for enhancing hair volume and thickness, and Finasteride for blocking hair loss causing hormones. Microneedling can boost Minoxidil's effects.
Potential treatments for hair loss, including Minoxidil, finasteride, RU58841 and various upcoming pharmaceuticals, gene editing and cloning. It is suggested that a cure, if found, would be highly profitable due to the large number of people affected by hair loss globally.
A user's 20 year journey with hair loss and the treatments they have used to manage it, including finasteride, minoxidil, a custom Strut Blend of Dutasteride, Minoxidil, Tretinoin, and Biotin, Nizoral shampoo, multivitamins, Vitamin D, B Complex, Dim, Clomid, exercise, diet, laser helmet, Toppik dark brown, and topical Finasteride. The user also talks about their successful life, lack of desire for children and high sperm count due to Clomid.
A user using finasteride and dutasteride to treat hair loss, but still losing hair rapidly after stopping minoxidil. Replies suggest that the user should try oral minoxidil or switch to dutasteride for better results.
A user who shared progress pictures of their scalp using a microscope camera, demonstrating the difference between healthy and miniaturized hair. Various explanations for the cause of this were discussed, such as DHT build-up in scalp sebum causing an autoimmune response leading to inflammation and eventual hair loss, with some suggesting a do-it-yourself treatment involving adding ascorbic acid powder to shampoo.
Hair loss treatments, such as minoxidil, finasteride, microneedling, ketoconazole shampoo and vitamins D3 and Omega 3, which appear to have been successful in regrowing hair on a user's temples that had been slick bald for 8-9 years.
Hair loss theory suggests imbalance between Vitamin D Receptor (VDR) and Androgen Receptor (AR) activation. Proposed treatment includes upregulating VDR, downregulating AR, and improving mitochondrial health.
The user shared their 5-year hair loss journey, initially using a product called Triphasic Progressive by Rene Furterer, which gave good results. Later, they switched to FDA-approved medications finasteride and minoxidil, which also helped, but they noticed the most significant progress with Triphasic. They're considering trying it again if minoxidil doesn't show improvements.
Treatments for hair loss, including finasteride, dutasteride, minoxidil, ketoconazole, microneedling, and low level laser light therapy, which aim to reduce DHT production, increase cell absorption and blood flow, and stimulate epidermal stem cells. It also stresses the importance of patience when using these treatments.
The conversation criticizes the negative attitude towards those concerned about side effects from hair loss treatments like finasteride and minoxidil, or who prefer natural remedies. Specific treatments discussed include finasteride, minoxidil, rosemary oil, and RU58841, with an agreement that finasteride and minoxidil are proven effective.
Quitting minoxidil can lead to significant hair loss, even in areas that were not thinning before, as hair becomes reliant on the treatment. Some users also report losing hair gains when stopping minoxidil despite taking finasteride.