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GlossaryProgenitor Cells

cells that can differentiate into specific cell types but are more limited than stem cells

Progenitor cells are a type of cell that has the capacity to differentiate into a specific type of cell but is more limited than a stem cell. Unlike stem cells, which can divide indefinitely and become any cell type, progenitor cells are already on the path to becoming a particular kind of cell and can only divide a limited number of times. They play a crucial role in tissue development and repair, including in the regeneration of hair follicles.

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community A concise, easy-to-understand post on Androgenic Alopecia theory and its practical applications

in Research/Science 92 upvotes 2 years ago

The mechanism of Androgenic Alopecia and practical applications of treatments like Minoxidil, Finasteride, RU58841, dermarolling, scalp massages, anti-fungals, progesterone, estrogen, PPAR-γ activators, reducing oxidative stress, and scalp exercises. It explains why DHT is important in AA and how other factors might be involved such as hypoxia, increased DKK-1 expression, morphological changes to the scalp, skull growth during childhood/puberty, and blood flow.

community Anyone using Peppermint oil/ similar oils and seeing growth?

in Research/Science 6 upvotes 5 months ago

Peppermint oil may be beneficial for hair growth, potentially outperforming minoxidil. Users discuss its effectiveness compared to other treatments like finasteride and RU58841.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 42 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 674 upvotes 1 month ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community Hair theory Scar tissue and Verteporfin

in Chat 25 upvotes 5 months ago

A user suggests that deeper microneedling with Verteporfin injections might help regrow hair in areas with scar tissue, alongside a DHT blocker. Another user explains that hair loss might be due to reduced Wnt/β-Catenin signaling and suggests that treatments like Minoxidil, Finasteride, and microneedling could potentially reverse it.

community Opinions on Scalp fibrosis and DHT?

in Research/Science 9 upvotes 2 years ago

The conversation discusses the theory that scalp fibrosis contributes to male pattern baldness (MPB) by increasing DHT concentration, and mentions treatments like Minoxidil. The user seeks opinions on the theory and the effectiveness of scalp massages.

community Minoxidil can prevent hair follicle miniaturization!?

in Minoxidil 6 upvotes 3 years ago

Minoxidil can prevent hair follicle miniaturization, not just stimulate hair growth. Finasteride and dutasteride don't work for everyone, suggesting DHT may not be the sole cause of hair loss; hair loss could be due to multiple factors, including autoimmune conditions.

community How do exosome injections for Hair Growth work?

in Is this regrowth? 1 upvotes 1 year ago

Exosome injections stimulate hair growth by using exosomes' healing potential to awaken dormant hair follicles and promote new hair cell creation. The procedure increases scalp blood circulation, encourages collagen and elastin formation, and regenerates hair follicles, improving hair thickness and quality.

community PP405 - hair stem cell stimulation

in Research/Science 51 upvotes 8 months ago

PP405, a topical LDH inhibitor, has shown to stimulate hair follicle stem cell proliferation in humans with moderate hair loss. They are advancing to more detailed trials this year.

community Scientists in Japan develop a new technique to reverse balding by transplanting a special kind of hair follicle cell into a patient's scalp

in Treatment 187 upvotes 4 years ago

A new technique developed by scientists in Japan to reverse balding using hair follicle cell transplants, and the discussion around the effectiveness of this approach compared to other treatments such as Minoxidil, finasteride, RU58841, Replicel, and Hairclone.

community TGF-Beta. Good or Bad? Help for treatment investment

in Treatment 12 upvotes 2 years ago

TGF-B affects hair growth, both causing stem cell division and death depending on amounts. Amplifica's treatment injects Scube3 to increase TGF-B for hair growth.

community Kintor Pharma Announces Completion of First Patient Enrollment in Phase II Clinical Trial of GT20029 for Treatment of Androgenetic Alopecia in China.

in Research/Science 132 upvotes 1 year ago

Kintor Pharma has started a Phase II trial in China for GT20029, a potential new treatment for hair loss. Participants are discussing the significance, potential release dates, and comparing it to other treatments and technologies like stem cell hair transplants and SAMIRNA.

community Epibiotech will now offer off-the-shelf allogeneic hair multiplication treatment in South Korea

in Research/Science 78 upvotes 2 years ago

Epibiotech will offer off-the-shelf allogeneic hair multiplication treatment in South Korea, using dermal papilla cells from donors to grow hair in balding areas. This method is cheaper and less invasive than traditional hair transplants.

community Bald groom beaten over fake hair.

in Satire 881 upvotes 1 year ago

A bald groom was beaten by the family of the bride for wearing a wig. The conversation discusses the cultural stigma around baldness in India and the consequences of deception in arranged marriages.

community Verteporfin day 84 update - donor hair regeneration human trials

in Research/Science 33 upvotes 2 years ago

A human trial involving verteporfin for hair regeneration, with the results showing some regrowth of 1-2 hairs in an area where a follicular unit was extracted. The conversation also suggested that future studies should involve higher doses and more frequent injections.

community My Theory Regarding a Cause and Cure for Androgenetic Alopecia

in Treatment 98 upvotes 4 years ago

Hair loss theory suggests imbalance between Vitamin D Receptor (VDR) and Androgen Receptor (AR) activation. Proposed treatment includes upregulating VDR, downregulating AR, and improving mitochondrial health.

community TDM-105795 phase 2 results are in!

in Research/Science 28 upvotes 9 months ago

TDM-105795 showed promising hair growth results, with higher efficacy than placebo and minimal side effects. It activates dormant hair follicle stem cells and may maintain gains without immediate loss, unlike minoxidil.

community Don't postpone treatments now with the allure and promise of future treatments.

in Treatment 88 upvotes 4 years ago

The conversation advises against waiting for future hair loss treatments and suggests using proven treatments like Finasteride and Minoxidil. Some users regret not starting treatment earlier, while others discuss the effectiveness and safety of current treatments and the potential of microneedling.

community 1.5 years fin plus almost 3 years min, I think I’ve definitely made progress but I’m still not where I want to be, advice?

in Progress Pictures 130 upvotes 10 months ago

The user has been using finasteride for 1.5 years and minoxidil for almost 3 years for hair loss, and has seen some maintenance of hair but not significant regrowth. Suggestions from others include switching to dutasteride, trying oral minoxidil, and considering microneedling or hair fibers for better appearance.

community Results of Procyanidin B2 in clinical studies

in Treatment 10 upvotes 4 years ago

Procyanidin B2, a compound derived from Annurca apples, as a potential treatment for pattern hair loss. Several clinical studies were mentioned, which found that procyanidin B2 could increase hair growth, density, and keratin content. Other treatments such as Minoxidil, Finasteride, and RU58841 were not discussed.

community PSA: Most men who stay on Fin will see the sexual side effects go away. Stop the fear mongering

in Finasteride/Dutasteride 191 upvotes 2 years ago

Finasteride can cause sexual side effects in less than 2% of men, but these often disappear over time, even if the treatment continues. Some users report persistent side effects, while others experience no issues or only temporary ones.

community NMN Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress

in Research/Science 14 upvotes 5 months ago

NMN shows promise in promoting hair growth by reducing oxidative stress and weakening androgens. It may be a beneficial addition to hair loss treatments like Minoxidil and Finasteride.

community Epibiotech Hair Multiplication

in Technology 16 upvotes 3 years ago

The conversation discusses hair loss treatments, specifically mentioning Minoxidil, finasteride, and RU58841. It also references Epibiotech's hair multiplication and cell therapy as potential solutions.

community OMG INTERVIEW W/ DR TSUJI - The GOD of Hair Cloning! MUST WATCH

in Research/Science 21 upvotes 3 years ago

The conversation discusses an interview with Dr. Tsuji about hair follicle stem cell multiplication and the financial challenges of starting human clinical trials. It also mentions the need for funding to secure a patent for a protein that promotes hair growth.

community Silicon Valley backed company aims to cure hair loss

in Technology 51 upvotes 2 years ago

A Silicon Valley-backed company aims to cure hair loss. Exciting advancements include mRNA therapies, gene editing, hair cloning, AR degraders, anti-androgens, cell-based rejuvenation, and AI-based drug discovery, with hopes for FDA approval of GT20029 within 10 years.

community This guy claims stem cells fixed his balding

in Is this regrowth? 301 upvotes 1 year ago

A man who claimed to have regrown his hair using stem cell treatment, sparking a debate about its effectiveness and cost. Some users suggested he might be using other treatments or substances, while others shared their own experiences with stem cell therapy for hair loss.

community Best Microneedle Lengths To Stimulate Stem Cells

in Microneedling 18 upvotes 1 year ago

Microneedling with needle lengths of 1.5mm to 2.5mm to stimulate hair follicle stem cells for potential hair growth. Using needles longer than 2.5mm is not recommended due to risk of puncturing veins in the scalp. A dermastamp is suggested over a roller.

community Do you believe there will be a game changing treatment in the next 10 years?

in Chat 67 upvotes 2 years ago

Users discuss potential game-changing hair loss treatments in the next 10 years. Some mention KX-826, SCUBE3, and stem cells as promising options, while others express doubt due to past disappointments and lack of focused research.

community My microneedling journey (no min, fin, etc)

in Microneedling 197 upvotes 1 month ago

The user experienced positive hair growth results using microneedling with rosemary and mint oil, without Minoxidil, Finasteride, or RU58841. They switched from a dermaroller to a microneedling pen and targeted different scalp areas weekly.

community microneedle, any long term users damage?

in Microneedling 35 upvotes 6 months ago

Microneedling is effective for hair growth, especially when combined with finasteride and minoxidil, but concerns exist about potential long-term skin damage. Users report increased collagen and elastin deposition, but the long-term effects on the scalp remain uncertain.