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Pyrilutamide is officially available for purchase, and users suggest Fluridil as an alternative topical anti-androgen. Some users report positive results with pyrilutamide from Koshine.

The conversation discusses that dutasteride may be more effective than finasteride for frontal hair loss due to higher 5ar Type 1 enzyme activity in that area. Some users question the validity of this information, while others confirm it with additional sources.

Minoxidil is used for hair loss and sometimes for high blood pressure, but it's outdated for the latter. For high blood pressure, it's combined with a beta blocker and diuretic to manage side effects.

Oral minoxidil treatment increased hair density and shaft caliber in AGA patients. Side effects included hypertrichosis and lower extremity edema, with younger patients experiencing fewer side effects.

The user experienced side effects from various hair loss treatments, including RU58841, finasteride, and dutasteride. They are uncertain about what treatment to try next.

The user began using topical minoxidil in 2020 without regrowth, then added 0.5mg finasteride, 2.5mg oral minoxidil daily, topical minoxidil/finasteride most days, and weekly micro needling since December 2022. They also use peppermint-infused jojoba oil for hair health and have noticed less gray hair.

Concerns about CosmeRNA safety mechanisms and potential side effects. Discussion includes comparisons to Fluridil and questions about nanoparticle specificity and siRNA stability.

People on testosterone replacement therapy (TRT) with aggressive androgenetic alopecia (AGA) discuss using Dutasteride or Finasteride, sometimes combined with topical treatments like RU58841 or CB-03-01 (Breezula), to prevent hair loss. Concerns about side effects and costs of certain treatments are mentioned, with one individual sharing their experience of slowed hair loss using Finasteride alone.

Exploring the potential of latanoprost as a hair loss treatment in combination with minoxidil and finasteride.

A user shared their positive experience with a hair transplant in Bangkok, Thailand, performed by Dr. Kongkiat Laorwong, costing ~$4,500 for 2,100 grafts. The user had been using finasteride, minoxidil, dutasteride, and oral minoxidil for hair loss treatment before the transplant and reported no side effects.

Influencers complicate hair loss treatments by promoting many products, but Minoxidil and Finasteride (or Dutasteride) are sufficient to start. The user criticizes influencers for not mentioning effective treatments like Finasteride.

A 24-year-old male reported a 7-month hairline recovery using 0.5mg of dutasteride daily with no side effects. Another user suggested adding minoxidil to the treatment.

The user started finasteride and experienced increased shedding for five months. They are concerned about how low vitamin levels might affect the shedding and effectiveness of finasteride.

New treatments for AGA are emerging, including pyrilutumide, gt0029, scube3, kx-826, and pp405. Verteporfin is mentioned as a promising option.

The conversation is about the potential impact of RU58841 on male fertility, specifically regarding sperm concentration, total count, and motility. The user is curious about the likelihood of RU58841 reducing fertility based on its mechanism of action and comparisons to similar substances.

A user shared their 4-year hair loss journey, highlighting that switching from topical to oral minoxidil and finasteride, along with dermarolling, significantly improved their hair growth. Another user mentioned using dutasteride, and the original poster emphasized the importance of dermarolling.

A user shared their 2-month progress using a topical solution with 6% Minoxidil and 0.3% Finasteride, applied nightly with a dropper. They reported no side effects and plan to update every 2 months.

A 24-year-old male has been using finasteride and minoxidil for a year with little hope. Suggestions include adding dutasteride, oral minoxidil, micro needling, and considering a hair transplant.

A user shared one-year progress using finasteride and minoxidil for hair loss at age 42. Suggestions included adding dermastamping, microneedling, and considering a hair transplant for further improvement.

High cholesterol may accelerate hair loss by reducing blood flow and increasing DHT levels. Treatments mentioned include Minoxidil, finasteride, and RU58841.

The conversation is about choosing between finasteride and minoxidil for hair loss treatment. Most users prefer finasteride, citing its effectiveness in stopping hair loss, while some mention using both for better results.

JW0061 shows superior hair growth results compared to existing treatments, with significant increases in hair follicles. The Wnt/β-catenin pathway is crucial for hair growth, and JW0061 activates this pathway effectively.

A user is considering starting spironolactone for hair loss without consulting a dermatologist, as previous dermatologists only recommended biotin, vitamins, or PRP. The user notes that spironolactone is affordable in their country.

Oral minoxidil has gained popularity as a hair loss treatment, with more online discussions and research showing it's safe in low doses. A viral New York Times article also contributed to its increased acceptance.

The conversation is about someone's hair growth progress after two months of daily treatment with 1 mg finasteride and 1.25 mg oral minoxidil. The replies are positive and encouraging.

A user shared their 4-month progress using oral minoxidil, finasteride, and derma rolling for hair loss. They reported positive results and expressed gratitude for the treatment.

The user has been using Finasteride for hair loss and is considering adding alphatradiol, stemoxydine, or 2% minoxidil to their regimen. They are concerned that stemoxydine, which shortens the resting phase of hair, might accelerate hair loss in those not using Finasteride by depleting hair cycles without strengthening miniaturized hairs.

The user shared progress pictures showing hair improvement after using finasteride for 3 months and minoxidil for 5 months, with no side effects and an increase in confidence, especially with an upcoming wedding. They encourage others considering treatment to start.

The conversation discusses the effectiveness of RU58841 for hair loss compared to pyrilutamide, which failed to show significant hair regrowth in trials. Some users report personal side effects with RU58841 and question the criteria for success in hair loss treatments.

The user mixed RU58841 with Minoxidil for hair loss treatment and experienced reduced hair fall and thicker hair but stopped due to chest pain and muscle twitching. They plan to use a new routine without RU58841 or Finasteride due to side effects, including various topical treatments and peptides.