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GlossaryGenetic Variants

differences in DNA sequence among individuals

Genetic variants, also known as genetic polymorphisms, are differences in the DNA sequence among individuals. These variations can affect how genes function and can influence traits such as hair color, susceptibility to diseases like alopecia, and response to medications. While some genetic variants have no impact on health, others can be significant in understanding genetic predispositions and developing personalized medical treatments.

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community CRISPR Is Curing People Right Now. Genetic Hair Loss is Next?

in Technology 107 upvotes 2 months ago

CRISPR shows promise for treating hair loss by targeting specific genes. Current treatments include Minoxidil and finasteride, but CRISPR could offer a more precise solution, though it is still expensive and in early stages.

community Phase II for Technoderma Therepeutic's TDM-105795 set to begin in April tentatively

in Research/Science 41 upvotes 1 year ago

Phase II for TDM-105795 for Androgenic Alopecia is set to begin in April 2023. The study aims to evaluate the efficacy and safety of TDM-105795 in male subjects.

community So we have 20k dollars human like machines available but no new effective treatment for hairloss since finasteride :)

in Chat 237 upvotes 2 months ago

There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.

community Should I dedicate my university studies to solving hair loss?

in Research/Science 373 upvotes 1 year ago

A 20 year old male who is balding and considering switching to a biology/chemistry program in order to find a low-cost, accessible solution for hair loss. Replies discuss the merits of this idea as well as potential treatments such as Minoxidil, finasteride, RU58841, TM5614, and ADQ.

community I am actually regrowing my hairline without minoxidil or finasteride (mechanical stimulation)

128 upvotes 6 years ago

Regrowing hairline without the use of Minoxidil or Finasteride, and instead using mechanical stimulation such as Derma Roller, Nizoral, Zinc Pyrithione, Scalp Massage, Scalp Exercise, Fish Oil and other topical solutions. It is cautioned that there are risks associated with not using medically-prescribed treatments, but it is suggested to consider mechanical stimulation in addition to those prescribed treatments.

community My son is 2 and already has my hairline. Is it too late for fin?

in Satire 873 upvotes 2 years ago

A user jokes about their 2-year-old son having their hairline and asks if it's too late for finasteride. Replies include humorous suggestions like growing a beard, working out, and hair transplants.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 667 upvotes 2 months ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community Switched from finasteride to dutasteride - 2 month update

in Finasteride/Dutasteride 6 upvotes 1 year ago

The user switched from finasteride to dutasteride for hair loss treatment, but experienced increased libido, itchy scalp, and accelerated hair loss. Another user suggested that genetic variations might cause dutasteride to be less effective and recommended checking for specific genetic markers.

community DHT levels after 4 weeks of Fina and 8 weeks of Fina + 4 weeks of Duta

in Update 35 upvotes 5 years ago

The user reported early stage diffuse hair thinning and increased DHT levels after 4 weeks on Finasteride and 8 weeks on Finasteride plus 4 weeks on Dutasteride, despite the medications being authentic and stored properly. They are considering increasing their Dutasteride dosage due to the lack of side effects and are unsure if the treatment is helping their hair.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community 3 months 5g Min only before/after, 26 y/o

in Is this regrowth? 454 upvotes 1 week ago

The user experienced significant hair regrowth after three months of using 5 mg oral minoxidil nightly and plans to add finasteride to maintain progress. Many recommend combining minoxidil with finasteride or dutasteride to prevent future hair loss.

community This sub after taking Finasteride for one day

in Satire 907 upvotes 4 months ago

The conversation humorously discusses the side effects of finasteride, particularly sexual dysfunction. Users share mixed experiences, with some reporting issues and others not.

community 137 years old and still far more hair than the average r/tressless user

in Satire 1060 upvotes 1 year ago

The post and conversation are about a user claiming to be 137 years old with a full head of hair. Specific treatments mentioned include dutasteride, RU58841, and minoxidil.

community Please stop looking for a natural way to stop your hairloss

in Chat 247 upvotes 2 years ago

There is no natural way to stop hair loss; pharmaceuticals like minoxidil, finasteride, and RU58841 are the only effective treatments. Some users report success with minoxidil and microneedling, while others discuss the side effects of finasteride.

community Hair Loss Breakthrough: Keratin Microsphere Gel Initiates Hair Regrowth in Days by Directly Targeting Follicles and Boosting Gene Expression - Gilmore Health News

in Treatment 463 upvotes 9 months ago

A new hair loss treatment involving Keratin Microsphere Gel is discussed, with skepticism and jokes about its effectiveness and comparisons to other treatments. Users are doubtful and make light of the situation, referencing past disappointments and the study's focus on mice.

community TWIST-1 and the cure: Is it really that easy?

in Research/Science 283 upvotes 2 years ago

TWIST-1 gene's role in hair loss and potential as a treatment target. Inhibiting TWIST-1 may prolong hair growth and reduce hair follicle sensitivity to DHT.

community Platelet rich plasma treatment

in Treatment 4 upvotes 8 months ago

A 27-year-old male experienced rapid hair loss after dengue fever, which activated a balding gene. The doctor suggested platelet-rich plasma treatment for hair regrowth.

community How soon is hair clone? Next five years?!

in Research/Science 15 upvotes 5 months ago

Hair cloning is humorously discussed as always being 5-7 years away, with skepticism about its near-term availability. Gene editing to reactivate dormant follicles is suggested as a more likely solution within the next ten years.

community CRISPR treatment for AGA on the horizon after approval for blood disorders

in Treatment 10 upvotes 10 months ago

CRISPR treatments for blood disorders have been approved, leading to discussions about its potential for treating hair loss (AGA). A study showed that editing a gene related to DHT sensitivity could lead to hair regrowth, suggesting CRISPR may eventually be used for AGA, but it's expected to be expensive and not soon available.

community I want to sacrifice my hair in the name of science

in Chat 12 upvotes 1 year ago

The conversation discusses various theories of hair loss, including DHT sensitivity and genetic factors, with the user willing to use themselves for research due to having a hair loss gene but different hair loss patterns compared to their brothers. Specific treatments were not mentioned in the provided text.

community When are we getting a cure to hair loss?

in Chat 1 year ago

Potential treatments for hair loss, including Minoxidil, finasteride, RU58841 and various upcoming pharmaceuticals, gene editing and cloning. It is suggested that a cure, if found, would be highly profitable due to the large number of people affected by hair loss globally.

community Silicon Valley backed company aims to cure hair loss

in Technology 51 upvotes 2 years ago

A Silicon Valley-backed company aims to cure hair loss. Exciting advancements include mRNA therapies, gene editing, hair cloning, AR degraders, anti-androgens, cell-based rejuvenation, and AI-based drug discovery, with hopes for FDA approval of GT20029 within 10 years.

community I believe CRISPR-on & CRISPR-off is an ultimate CURE for baldness, unlike Hair Cloning or hair loss treatments.

in Research/Science 22 upvotes 3 years ago

The conversation discusses CRISPR-on & CRISPR-off as a potential cure for baldness, contrasting it with hair cloning and other treatments like Minoxidil, finasteride, and RU58841. It also mentions the potential of mRNA for gene expression control and the prioritization of gene editing for severe genetic conditions.

community Mystery compound found to be safe and effective at treating hair loss. Details in comments.

in Technology 6 upvotes 5 years ago

A compound called MTP3 from the Monoterpene family was found to be safe and highly effective at treating hair loss by inhibiting the FGF5 gene, but its identity is undisclosed for commercial reasons. No specific treatments like Minoxidil, finasteride, or RU58841 were discussed.

community Can a folate deficiency make androgenetic alopecia worse?

in Treatment 1 upvotes 11 months ago

The user is treating androgenetic alopecia with finasteride and discovered a folic acid deficiency. They are asking if curing the deficiency can worsen or improve their hair condition.

community Can't tell if I'm balding, or simply inheriting my father's bizarre hairline - please let me know your thoughts [33M]

7 upvotes 10 years ago

A 33-year-old man is concerned about potential hair loss, comparing his hairline to his father's and noticing increased shedding and thinning. He is considering treatments like Minoxidil and Finasteride but is unsure if he has male pattern baldness.

community 3 months progress!! Fin + Min + Derma roller + Nizoral Shampoo.

in Progress Pictures 564 upvotes 1 year ago

The post discusses a user's successful hair regrowth after 3 months using 1 mg oral finasteride, oral minoxidil, weekly 1.5mm derma rolling, and Nizoral shampoo every other day, with no side effects. The conversation includes various responses, questions about the user's ethnicity and previous scalp condition, and suggestions for topical treatments.

community Could this shampoo that's meant to restore hair cause a shed before causing regrowth?

in Product 1 upvotes 1 year ago

The user started experiencing hair thinning in November and began using a specific shampoo and conditioner about two weeks ago, but noticed quicker thinning since starting the product. They are questioning if the product could cause initial shedding before promoting hair regrowth, similar to how finasteride works.

community Difference: GT20029 vs CosmeRNA

in Treatment 8 upvotes 1 year ago

GT20029 and CosmeRNA are both potential hair loss treatments; GT20029 breaks down the androgen receptor, while CosmeRNA prevents its production. Continuous use is needed, but less frequently than current treatments like Minoxidil and Finasteride.

community Is hair cloning and setipiprant coming in 2020?

in Question 6 upvotes 8 years ago

The conversation discusses potential hair loss treatments, including hair cloning, setipiprant, and topical finasteride, questioning their availability and effectiveness as permanent cures. The user is inquiring about the release dates and efficacy of these treatments.