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GlossaryGene Silencing (Gene Knockdown)

reducing or preventing gene expression using various biological mechanisms

Gene silencing, also known as gene suppression or gene knockdown, is a process by which the expression of a specific gene is reduced or entirely prevented. This can occur naturally through mechanisms like RNA interference (RNAi) or be induced artificially using techniques such as CRISPR-Cas9. It is a valuable tool in research and medicine for studying gene function and developing treatments for diseases, including those related to hair loss and alopecia.

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community Hair Loss Breakthrough: Keratin Microsphere Gel Initiates Hair Regrowth in Days by Directly Targeting Follicles and Boosting Gene Expression - Gilmore Health News

in Treatment 463 upvotes 8 months ago

A new hair loss treatment involving Keratin Microsphere Gel is discussed, with skepticism and jokes about its effectiveness and comparisons to other treatments. Users are doubtful and make light of the situation, referencing past disappointments and the study's focus on mice.

community TWIST-1 and the cure: Is it really that easy?

in Research/Science 283 upvotes 2 years ago

TWIST-1 gene's role in hair loss and potential as a treatment target. Inhibiting TWIST-1 may prolong hair growth and reduce hair follicle sensitivity to DHT.

community Platelet rich plasma treatment

in Treatment 4 upvotes 7 months ago

A 27-year-old male experienced rapid hair loss after dengue fever, which activated a balding gene. The doctor suggested platelet-rich plasma treatment for hair regrowth.

community How soon is hair clone? Next five years?!

in Research/Science 15 upvotes 4 months ago

Hair cloning is humorously discussed as always being 5-7 years away, with skepticism about its near-term availability. Gene editing to reactivate dormant follicles is suggested as a more likely solution within the next ten years.

community CRISPR treatment for AGA on the horizon after approval for blood disorders

in Treatment 11 upvotes 9 months ago

CRISPR treatments for blood disorders have been approved, leading to discussions about its potential for treating hair loss (AGA). A study showed that editing a gene related to DHT sensitivity could lead to hair regrowth, suggesting CRISPR may eventually be used for AGA, but it's expected to be expensive and not soon available.

community I want to sacrifice my hair in the name of science

in Chat 12 upvotes 1 year ago

The conversation discusses various theories of hair loss, including DHT sensitivity and genetic factors, with the user willing to use themselves for research due to having a hair loss gene but different hair loss patterns compared to their brothers. Specific treatments were not mentioned in the provided text.

community When are we getting a cure to hair loss?

in Chat 1 year ago

Potential treatments for hair loss, including Minoxidil, finasteride, RU58841 and various upcoming pharmaceuticals, gene editing and cloning. It is suggested that a cure, if found, would be highly profitable due to the large number of people affected by hair loss globally.

community Silicon Valley backed company aims to cure hair loss

in Technology 51 upvotes 2 years ago

A Silicon Valley-backed company aims to cure hair loss. Exciting advancements include mRNA therapies, gene editing, hair cloning, AR degraders, anti-androgens, cell-based rejuvenation, and AI-based drug discovery, with hopes for FDA approval of GT20029 within 10 years.

community I believe CRISPR-on & CRISPR-off is an ultimate CURE for baldness, unlike Hair Cloning or hair loss treatments.

in Research/Science 22 upvotes 3 years ago

The conversation discusses CRISPR-on & CRISPR-off as a potential cure for baldness, contrasting it with hair cloning and other treatments like Minoxidil, finasteride, and RU58841. It also mentions the potential of mRNA for gene expression control and the prioritization of gene editing for severe genetic conditions.

community Mystery compound found to be safe and effective at treating hair loss. Details in comments.

in Technology 6 upvotes 5 years ago

A compound called MTP3 from the Monoterpene family was found to be safe and highly effective at treating hair loss by inhibiting the FGF5 gene, but its identity is undisclosed for commercial reasons. No specific treatments like Minoxidil, finasteride, or RU58841 were discussed.

community Can a folate deficiency make androgenetic alopecia worse?

in Treatment 1 upvotes 9 months ago

The user is treating androgenetic alopecia with finasteride and discovered a folic acid deficiency. They are asking if curing the deficiency can worsen or improve their hair condition.

community Can't tell if I'm balding, or simply inheriting my father's bizarre hairline - please let me know your thoughts [33M]

7 upvotes 10 years ago

A 33-year-old man is concerned about potential hair loss, comparing his hairline to his father's and noticing increased shedding and thinning. He is considering treatments like Minoxidil and Finasteride but is unsure if he has male pattern baldness.

community CRISPR Is Curing People Right Now. Genetic Hair Loss is Next?

in Technology 107 upvotes 1 month ago

CRISPR shows promise for treating hair loss by targeting specific genes. Current treatments include Minoxidil and finasteride, but CRISPR could offer a more precise solution, though it is still expensive and in early stages.

community 3 months progress!! Fin + Min + Derma roller + Nizoral Shampoo.

in Progress Pictures 565 upvotes 1 year ago

The post discusses a user's successful hair regrowth after 3 months using 1 mg oral finasteride, oral minoxidil, weekly 1.5mm derma rolling, and Nizoral shampoo every other day, with no side effects. The conversation includes various responses, questions about the user's ethnicity and previous scalp condition, and suggestions for topical treatments.

community Could this shampoo that's meant to restore hair cause a shed before causing regrowth?

in Product 1 upvotes 1 year ago

The user started experiencing hair thinning in November and began using a specific shampoo and conditioner about two weeks ago, but noticed quicker thinning since starting the product. They are questioning if the product could cause initial shedding before promoting hair regrowth, similar to how finasteride works.

community Difference: GT20029 vs CosmeRNA

in Treatment 9 upvotes 1 year ago

GT20029 and CosmeRNA are both potential hair loss treatments; GT20029 breaks down the androgen receptor, while CosmeRNA prevents its production. Continuous use is needed, but less frequently than current treatments like Minoxidil and Finasteride.

community Is hair cloning and setipiprant coming in 2020?

in Question 6 upvotes 8 years ago

The conversation discusses potential hair loss treatments, including hair cloning, setipiprant, and topical finasteride, questioning their availability and effectiveness as permanent cures. The user is inquiring about the release dates and efficacy of these treatments.

community [21 M] - 2.5 Year Progress Report

10 upvotes 9 years ago

A 21-year-old man shared his 2.5-year experience with hair loss treatments, including 1mg Propecia (finasteride) nightly, 12.5% Minoxidil once daily, 2% Nizoral shampoo 2-4 times a week, and later 5% Minoxidil once daily. He experienced minor side effects like watery semen and itchy scalp, and while he's seen fluctuations in hair growth, he's generally happy with the results and is considering experimental treatments like CB-03-01 and RU58841.

community Finasteride + Cialis together long term?

in Treatment 3 upvotes 2 months ago

The user has been on 1mg finasteride for a year, experiencing low libido and moderate erectile issues. They are considering using Cialis daily with finasteride long term to address these side effects.

community Found an interesting little article

in Research/Science 6 upvotes 2 months ago

A new painless microneedle patch shows promise in reversing hair loss. The discussion focuses on potential new treatments beyond common options like Minoxidil, finasteride, and RU58841.

community one month difference, can’t tell if it’s gotten better or wors

in Is this regrowth? 7 upvotes 2 months ago

The user is unsure if their hair has improved or worsened after inconsistent minoxidil use, iron, and vitamin D supplements. A reply suggests the hair looks better but recommends consistent photo angles for accurate comparison.

community Topical Dutasteride - Non-Hormonal, Side Effect Free 5ARI?

in Treatments 372 upvotes 2 months ago

Topical dutasteride is suggested as a low side-effect treatment for hair loss, with a proposed dose of 0.025% 1ml/day. It is considered better than finasteride due to its even inhibition of DHT isoforms and lower systemic absorption.

community Mechanism of action of alfatradiol (17 alpha estradiol)

in Research/Science 6 upvotes 5 months ago

The conversation discusses the mechanism of action of alfatradiol (17 alpha estradiol) in treating hair loss. It explores theories that it either inhibits 5 alpha reductase to prevent T->DHT conversion or aromatizes scalp T into 17-alpha-estradiol to save hair.

community Damn, the trash hormone DHT was losing so hard it pulled the "old social media post" card

in Chat 198 upvotes 5 months ago

The conversation is about hair loss treatments, including minoxidil, finasteride, dutasteride, tretinoin, stemoxydine, adenosine, castor oil, baicalin, and bimatoprost. The user shares their nightly and morning routines and discusses the role of DHT in hair loss.

community A hill on which I will die: The DHT itch absolutely exists

in Research/Science 212 upvotes 5 months ago

The DHT itch is linked to hair loss and persists despite finasteride use; switching to dutasteride helped alleviate the itch and promoted regrowth. Some users suggest seborrheic dermatitis as a cause and recommend treatments like medicated shampoos, vitamin D, and minoxidil.

community The worst part of balding is its harder to maintain a balding head

in Shaved/buzzed 327 upvotes 7 months ago

The conversation discusses the challenges of maintaining a balding head, with some preferring to shave regularly and others choosing to embrace their hair loss. Specific treatments or concerns about hair transplants and societal perceptions of balding are also mentioned.

community Update: Norwood 6 trying the bounce back

in Progress Pictures 68 upvotes 10 months ago

User achieved hair regrowth using 1 mg oral finasteride, topical minoxidil twice daily, and occasional microneedling. They are happy with the progress despite still having thin hair on top.

community I find it crazy how some people like this bloke have 0 DHT sensitivity. He is on grams of anabolic steroids and has a full, thick head of hair. I wish all of on here had this guys hair genes lol

in Satire 443 upvotes 1 year ago

The conversation is about hair loss and the possibility of maintaining a full head of hair while using anabolic steroids. Some users believe that having good hair genes and taking hair loss protocols can help prevent hair loss while on steroids.

community Prolactin’s role in antitumor activity of the immune system – a safety concern for HMI-115?

in Research/Science 3 upvotes 1 year ago

Hair loss discussion includes treatments Minoxidil, Finasteride, and RU58841. Prolactin's role in immune system's antitumor activity raises safety concerns for HMI-115.

community Is Topical Dutasteride best for preventative loss?

in Finasteride/Dutasteride 7 upvotes 1 year ago

The user is considering using topical dutasteride to prevent hair loss progression from Norwood 1 to Norwood 2 at age 25, and is concerned about the long-term effectiveness and potential shedding from the treatment. They are currently using a shampoo with caffeine, rosemary, and saw palmetto, and have noticed hair thinning and changes since age 20.