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GlossaryFollicular Keratinocytes

specialized cells in hair follicles producing keratin for hair

Follicular keratinocytes are specialized cells found in hair follicles, the structures in the skin that produce hair. These cells are responsible for producing keratin, a protein that forms the structural foundation of hair. They play a crucial role in the growth and health of hair by continuously dividing and differentiating to form the hair shaft.

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community DIY treatment... Shedding completely stopped after 1.5 yrs

in Treatment 249 upvotes 2 years ago

Vitamin C mixed with shampoo stopped shedding and promoted hair regrowth after 1.5 years. Both the person and their wife experienced significant hair loss reduction with this method.

community COMPLETE OVERVIEW of the Treatment of androgenetic alopecia in men

26 upvotes 10 years ago

Male androgenetic alopecia is commonly treated with topical minoxidil and oral finasteride, both requiring continuous use. Other options include hair restoration surgery, dutasteride, light therapy, and camouflaging agents.

community Topical Finasteride Doesn't Directly Reduce 5ar Enzyme on Scalp

in Finasteride/Dutasteride 72 upvotes 1 year ago

Topical Finasteride doesn't directly reduce 5ar enzyme on scalp and has the same mechanism as oral, needing to go through the liver. Users debate the accuracy of this information and discuss various studies and experiences.

community Fevipiprant 2019!

17 upvotes 8 years ago

The conversation discusses Fevipiprant, an asthma drug that may block CRTH2 and potentially stop male pattern baldness (MPB) without inhibiting DHT. It also mentions the use of finasteride and dutasteride for hair loss.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 42 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community How all hormones affect our hair follicles. Not just DHT. Take a look at this paper. Prolactin, melatonin, cortisol, progesterone, testosterone and more

in Research/Science 126 upvotes 2 years ago

The conversation discusses various factors affecting hair loss, not just DHT, and mentions treatments like Minoxidil, finasteride, and melatonin. Some users report personal experiences with these treatments and hormone tests, while others speculate on the role of hormones like prolactin and cortisol in hair loss.

community Comprehensive Microneedling Guide

in Microneedling 293 upvotes 2 years ago

Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

community A meta analysis of 18 popular hair loss treatments. An 2022 guide on efficacy. From finasteride and minoxidil to caffeine shampoo, saw palmetto and biotin. 96 Scientific References included.

in Research/Science 101 upvotes 2 years ago

Most hair loss treatments are ineffective; only finasteride, dutasteride, and minoxidil show effectiveness.

community HairClone developing cell replacement treatments for Hair Loss

6 upvotes 6 years ago

HairClone is developing cell replacement treatments to rejuvenate and generate hair follicles, and has launched a crowdfunding campaign. A user expressed skepticism about the need for crowdfunding.

community Interesting article links major MPB theories to western diet (and life-style)

in Research/Science 56 upvotes 1 month ago

Poor diet and lifestyle contribute to male pattern baldness. Treatments like Minoxidil, dietary changes, and lifestyle adjustments may help slow hair loss.

community SAFFLOWER OIL good alternative for Minoxidil?

in Treatment 1 upvotes 4 years ago

Safflower oil is suggested as an alternative to minoxidil for hair growth, with benefits including scalp conditioning and hair strength enhancement. Studies indicate it may also reverse scalp dermatitis, alopecia, and prevent premature grayness.

community New hack? Tretinoin enhances minoxidil response in androgenetic alopecia patients by upregulating follicular sulfotransferase enzymes

in Research/Science 17 upvotes 2 years ago

The conversation discusses how Tretinoin may improve the effectiveness of Minoxidil for treating hair loss by increasing the activity of certain enzymes in hair follicles. One user comments that this information is not new.

community The Korean began to suspect something. But they understood the mechanism to some extent. ( Cold shock therapy promotes hair growth in association with upregulation of cold-inducible RNA-binding protein and vascular endothelial growth factor)

in Research 84 upvotes 3 weeks ago

Cold shock therapy may promote hair growth by stimulating follicular muscles and affecting stem cells. The exact mechanisms and full range of elements involved are not yet fully understood.

community Progress with 6 Years fin and a FUT (2017 vs 2023)

in Is this regrowth? 210 upvotes 1 year ago

The post discusses a user's six-year progress with finasteride and a Follicular Unit Transplant (FUT) for hair loss. The user shared before and after photos in reverse order, leading to confusion, but overall, the community responded positively to the user's hair regrowth.

community How is verteporfin doing in trials?

in Chat 9 upvotes 1 year ago

The conversation is about the progress of verteporfin in hair loss trials, with users expressing curiosity about its effectiveness and updates. Specific treatments mentioned include FUE (Follicular Unit Extraction) combined with verteporfin, with one reported case of donor area regrowth after a year, and three patients being monitored post-treatment by Dr. Bloxham with monthly updates on YouTube.

community Verteporfin day 84 update - donor hair regeneration human trials

in Research/Science 33 upvotes 2 years ago

A human trial involving verteporfin for hair regeneration, with the results showing some regrowth of 1-2 hairs in an area where a follicular unit was extracted. The conversation also suggested that future studies should involve higher doses and more frequent injections.

community Is Minoxidil + Peppermint/Rosemary Oil a good combo?

in Chat 1 upvotes 5 months ago

Combining Minoxidil with Peppermint or Rosemary Oil may enhance hair growth. Users discuss the potential benefits of this combination for treating hair loss.

community HELP! Hair transplant for me (with pics) ?

in Transplants 8 upvotes 2 years ago

User tried various hair loss treatments with side effects. Seeks advice on hair transplant without maintenance drug.

community How well can HRT reduce scalp tension?

in Transgender 6 upvotes 1 year ago

A trans woman is curious about the impact of HRT on hair regrowth and scalp tension. Her current regimen includes finasteride, spironolactone, estradiol, ketoconazole, vitamin D, iron, and plans to add oral minoxidil and restart derma rolling.

community Month 5 – Fin, min, microneedling 1x month.

in Progress Pictures 70 upvotes 1 year ago

User made progress with hair loss using Fin, Min, and microneedling. Experienced side effects like improved skin, brain fog, and memory issues, but adjusting Fin dosage helped.

community Dental technician is convinced that he has found the cause of pattern hair loss

in Research/Science 317 upvotes 4 months ago

A dental technician claims malocclusion causes pattern hair loss due to poor scalp circulation. Users debate this, noting treatments like finasteride, minoxidil, and microneedling focus on DHT and blood flow.

community 10 Days Post-Op: Hair Transplant Results and Experience

in Progress Pictures 509 upvotes 6 months ago

A user shared their positive experience with a hair transplant at Dr. Resul Yaman Hair Clinic in Istanbul, including before and after photos. They are considering taking oral Minoxidil post-operation but are avoiding Finasteride due to side effects.

community How is it possible for someone to be a non responder to ORAL minoxidil?

in Minoxidil 66 upvotes 8 months ago

Some individuals do not respond to oral minoxidil for hair loss, despite it generally working by improving blood flow to hair follicles. Factors like metabolism, drug interactions, and individual variations in the drug's activation may influence its effectiveness.

community Possible topical option for preventing BDNF-related hair loss

in Research/Science 7 upvotes 1 year ago

The conversation discusses hair loss linked to BDNF-increasing nootropics like Semax and Lions Mane. Suggested topical treatments include capsaicin, beta-glucan, and ginseng to counteract TGF-B activation.

community [Advice Needed] On 50mg Fin and 100mg oral Min daily, density isn’t as high as I’d like. Next steps?

in Satire 418 upvotes 1 year ago

Treatments for hair loss, such as minoxidil and finasteride; scalp micropigmentation; and humorous approaches to accepting baldness.

community Don’t call it a comeback! Progress pics. 4/14/22- 1/13/23. Been on Fin 1mg daily, min once a day and Keto 2% twice a week.

in Progress Pictures 67 upvotes 1 year ago

The user's progress with hair loss treatments, including Fin 1mg daily, Minoxidil once a day and Keto 2% twice a week. Another user commented in response.

community does lowering your prolactin levels regrow hair?

in Research/Science 10 upvotes 1 year ago

The potential of lowering prolactin levels to regrow hair, with a reference to Bayer's drug HMI 115 which has been indicated as having this effect. Treatments mentioned include Minoxidil and Finasteride, as well as RU58841.

community Can someone explain the science behind why Finasteride doesn't stop you from losing regrown hairs from minoxidil?

in Minoxidil 100 upvotes 2 weeks ago

Finasteride prevents further hair loss by blocking DHT, while minoxidil stimulates hair growth by prolonging the active phase of hair follicles. Stopping minoxidil can lead to loss of regrown hair because finasteride does not address the same growth mechanism.

community Is microneedling + minoxidil better than oral minoxidil

in Chat 29 upvotes 1 month ago

Oral minoxidil is considered more effective for hair regrowth than topical minoxidil, but it carries higher risks. Combining microneedling with topical minoxidil can enhance absorption, but oral minoxidil with microneedling shows significant results.